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While sequencing-based studies have shown that damage formation is influenced by DNA sequence context, secondary structures, and chromatin features, how OGG1-mediated repair is regulated within chromatin remains unclear. Here, we apply CLAPS-seq to generate genome-wide, single-nucleotide resolution maps of OGG1-mediated repair over time in human cells, and systematically analyze how chromatin context affects repair efficiency across hierarchical scales. We find that chromatin accessibility governs rapid initial repair, whereas higher-order chromatin structures increasingly influence later-phase repair. In addition, nucleosome occupancy and transcription factor binding, exemplified by CCCTC-binding factor (CTCF), modulate OGG1-mediated repair at both local and base scales. Overall, mutational outcomes correlate more strongly with repair dynamics than with damage levels. Together, these findings establish a comprehensive framework linking chromatin organization, DNA repair kinetics, and oxidatively induced mutagenesis, and offer new insights into the origins of mutation patterns in cancer and diseases associated with oxidative stress.<\/jats:p>","DOI":"10.1093\/nar\/gkaf1330","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:12:03Z","timestamp":1762521123000},"source":"Crossref","is-referenced-by-count":3,"title":["Dynamic genome-wide mapping reveals how chromatin context shapes OGG1-mediated repair and related mutagenesis in human cells"],"prefix":"10.1093","volume":"53","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Fifth People\u2019s Hospital, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Yin","sequence":"additional","affiliation":[{"name":"Shanghai Fifth People\u2019s Hospital, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics and Department of Hematology and Oncology, Children\u2019s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 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Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-546X","authenticated-orcid":false,"given":"Maoxiang","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics and Department of Hematology and Oncology, Children\u2019s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-0195","authenticated-orcid":false,"given":"Jinchuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Fifth People\u2019s Hospital, Shanghai Key Laboratory of Medical 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