{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:21:30Z","timestamp":1772025690096,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15CA263784"],"award-info":[{"award-number":["1R15CA263784"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15CA305114"],"award-info":[{"award-number":["1R15CA305114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES009558"],"award-info":[{"award-number":["R01 ES009558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA215347"],"award-info":[{"award-number":["CA215347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA229530"],"award-info":[{"award-number":["CA229530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04267"],"award-info":[{"award-number":["19H04267"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Takeda Bioscience Research"},{"name":"Mitsubishi Research"},{"name":"Naito Research"},{"name":"Astellas Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ataxia-telangiectasia mutated and RAD3-related (ATR) and its partner ATR-interacting protein (ATRIP) function as a critical proximal sensor and transducer of the DNA damage response (DDR). Several ATR substrates, including p53 and CHK1, are crucial for the coordination of cell cycle phase transitions, transcription, and DNA repair when cells sustain DNA damage. While much is known about ATR activation mechanisms, it is less clear how ATR signaling is negatively regulated in cells. Here, we identify the DNA repair protein REV7 as a novel direct binding partner of ATRIP. We define a REV7-interaction motif in ATRIP, which, when mutated, abrogates the REV7\u2013ATRIP interaction in vitro and in intact cells. Using in vitro kinase assays, we show that REV7 inhibits ATR-mediated phosphorylation of its substrates, including p53. Disruption of the REV7\u2013ATRIP interaction also enhances phosphorylation of CHK1 at Ser317 in intact cells. Taken together, our results establish REV7 as a critical negative regulator of ATR signaling. REV7 has pleiotropic roles in multiple DDR pathways, including Translesion Synthesis, DNA double-strand break resection, and p53 stability and may play a central role in the integration of multiple genome maintenance pathways.<\/jats:p>","DOI":"10.1093\/nar\/gkaf1527","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:29:01Z","timestamp":1768652941000},"source":"Crossref","is-referenced-by-count":1,"title":["REV7 associates with ATRIP and inhibits ATR kinase activity"],"prefix":"10.1093","volume":"54","author":[{"given":"Megan","family":"Biller","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Nipper","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Kayali","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skyler","family":"Kuncik","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2824-4499","authenticated-orcid":false,"given":"Hiroyuki","family":"Sasanuma","sequence":"additional","affiliation":[{"name":"Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science , Tokyo \u00a0 156-8506, \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Duke University School of Medicine , Durham, \u00a0 NC 27710, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina , Chapel Hill, \u00a0 NC 27599, \u00a0","place":["United States"]},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, \u00a0 NC 27599, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-5757","authenticated-orcid":false,"given":"Junya","family":"Tomida","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Carolina at Charlotte , Charlotte, NC 28223, \u00a0","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"2026012104494431800_B1","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/35056049","article-title":"Chromosomal stability and the DNA double-stranded break connection","volume":"2","author":"van\u00a0Gent","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2026012104494431800_B2","first-page":"275","article-title":"Human DNA repair genes","volume":"577","author":"Wood","year":"2005","journal-title":"Mutat Res"},{"key":"2026012104494431800_B3","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012104494431800_B4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/549","article-title":"Positional cloning of the gene for Nijmegen breakage syndrome","volume":"19","author":"Matsuura","year":"1998","journal-title":"Nat Genet"},{"key":"2026012104494431800_B5","doi-asserted-by":"publisher","first-page":"e1002945","DOI":"10.1371\/journal.pgen.1002945","article-title":"Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR\u2013ATRIP seckel syndrome","volume":"8","author":"Ogi","year":"2012","journal-title":"PLoS Genet"},{"key":"2026012104494431800_B6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1083\/jcb.201009074","article-title":"Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair","volume":"193","author":"Zhang","year":"2011","journal-title":"J Cell Biol"},{"key":"2026012104494431800_B7","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.ajhg.2015.04.022","article-title":"Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia","volume":"96","author":"Hira","year":"2015","journal-title":"Am Hum Genet"},{"key":"2026012104494431800_B8","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1172\/JCI88010","article-title":"Biallelic inactivation of REV7 is associated with Fanconi anemia","volume":"126","author":"Bluteau","year":"2016","journal-title":"J Clin Invest"},{"key":"2026012104494431800_B9","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41594-021-00602-9","article-title":"Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress","volume":"28","author":"Xu","year":"2021","journal-title":"Nat Struct Mol Biol"},{"key":"2026012104494431800_B10","doi-asserted-by":"publisher","first-page":"22719","DOI":"10.1074\/jbc.M001002200","article-title":"Utilization of oriented peptide libraries to identify substrate motifs selected by ATM","volume":"275","author":"O\u2019Neill","year":"2000","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B11","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1038\/emboj.2009.281","article-title":"Emerging common themes in regulation of PIKKs and PI3Ks","volume":"28","author":"Lempiainen","year":"2009","journal-title":"EMBO J"},{"key":"2026012104494431800_B12","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.dnarep.2009.04.006","article-title":"Common mechanisms of PIKK regulation","volume":"8","author":"Lovejoy","year":"2009","journal-title":"DNA Repair (Amst)"},{"key":"2026012104494431800_B13","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the Heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol Cell"},{"key":"2026012104494431800_B14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes Dev"},{"key":"2026012104494431800_B15","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"2026012104494431800_B16","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1093\/nar\/gkl550","article-title":"A dynamic model for replication protein A (RPA) function in DNA processing pathways","volume":"34","author":"Fanning","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2026012104494431800_B17","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1083\/jcb.200810185","article-title":"TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks","volume":"184","author":"Yan","year":"2009","journal-title":"J Cell Biol"},{"key":"2026012104494431800_B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.dnarep.2014.05.001","article-title":"Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR\u2013ATRIP and promotes TopBP1 recruitment to sites of UV-damage","volume":"21","author":"Ohashi","year":"2014","journal-title":"DNA Repair (Amst)"},{"key":"2026012104494431800_B19","doi-asserted-by":"publisher","first-page":"21956","DOI":"10.1074\/jbc.C116.747758","article-title":"Ewing tumor-associated antigen 1 interacts with replication protein A to promote restart of stalled replication forks","volume":"291","author":"Feng","year":"2016","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B20","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/ncb3422","article-title":"Activation of the ATR kinase by the RPA-binding protein ETAA1","volume":"18","author":"Haahr","year":"2016","journal-title":"Nat Cell Biol"},{"key":"2026012104494431800_B21","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/gtc.12031","article-title":"NBS1 directly activates ATR independently of MRE11 and TOPBP1","volume":"18","author":"Kobayashi","year":"2013","journal-title":"Genes Cells"},{"key":"2026012104494431800_B22","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"2026012104494431800_B23","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.dnarep.2004.03.006","article-title":"Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time","volume":"3","author":"Lukas","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"2026012104494431800_B24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/358015a0","article-title":"Cancer. p53, guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"2026012104494431800_B25","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/jcb.21091","article-title":"53 modulation of the DNA damage response","volume":"100","author":"Helton","year":"2007","journal-title":"J Cell Biochem"},{"key":"2026012104494431800_B26","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1128\/MCB.21.13.4129-4139.2001","article-title":"ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1","volume":"21","author":"Zhao","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2026012104494431800_B27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1101\/gad.13.2.152","article-title":"A role for ATR in the DNA damage-induced phosphorylation of p53","volume":"13","author":"Tibbetts","year":"1999","journal-title":"Genes Dev"},{"key":"2026012104494431800_B28","doi-asserted-by":"publisher","first-page":"e21373","DOI":"10.1096\/fj.202001636RRR","article-title":"ATR prevents Ca(2+) overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J"},{"key":"2026012104494431800_B29","doi-asserted-by":"publisher","first-page":"14384","DOI":"10.1074\/jbc.RA118.004598","article-title":"Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b","volume":"293","author":"Kratz","year":"2018","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B30","doi-asserted-by":"publisher","first-page":"E10642","DOI":"10.1073\/pnas.1803177115","article-title":"BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes","volume":"115","author":"Sasanuma","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012104494431800_B31","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/em.22201","article-title":"Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms","volume":"59","author":"Saha","year":"2018","journal-title":"Environ and Mol Mutagen"},{"key":"2026012104494431800_B32","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1107\/S0907444906029799","article-title":"A time- and cost-efficient system for high-level protein production in mammalian cells","volume":"62","author":"Aricescu","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"2026012104494431800_B33","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1073\/pnas.1324001111","article-title":"Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012104494431800_B34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/15384101.2024.2333227","article-title":"REV7-p53 interaction inhibits ATM-mediated DNA damage signaling","volume":"23","author":"Biller","year":"2024","journal-title":"Cell Cycle"},{"key":"2026012104494431800_B35","doi-asserted-by":"publisher","first-page":"e0030321","DOI":"10.1128\/MCB.00303-21","article-title":"FANCD2-associated nuclease 1 partially compensates for the lack of exonuclease 1 in mismatch repair","volume":"41","author":"Kratz","year":"2021","journal-title":"Mol Cell Biol"},{"key":"2026012104494431800_B36","doi-asserted-by":"publisher","first-page":"33457","DOI":"10.18632\/oncotarget.16508","article-title":"The dominant role of proofreading exonuclease activity of replicative polymerase epsilon in cellular tolerance to cytarabine (Ara-C)","volume":"8","author":"Tsuda","year":"2017","journal-title":"Oncotarget"},{"key":"2026012104494431800_B37","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/em.22371","article-title":"Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells","volume":"61","author":"Ibrahim","year":"2020","journal-title":"Environ and Mol Mutagen"},{"key":"2026012104494431800_B38","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1042\/BJ20031833","article-title":"Purification of Drosophila DNA polymerase zeta by REV1 protein-affinity chromatography","volume":"382","author":"Takeuchi","year":"2004","journal-title":"Biochem J"},{"key":"2026012104494431800_B39","doi-asserted-by":"publisher","first-page":"23445","DOI":"10.1074\/jbc.M604317200","article-title":"Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol","volume":"281","author":"Takata","year":"2006","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B40","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1093\/nar\/gku1385","article-title":"REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase zeta","volume":"43","author":"Tomida","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026012104494431800_B41","doi-asserted-by":"publisher","first-page":"6930","DOI":"10.1093\/nar\/gkt467","article-title":"A novel interplay between the Fanconi anemia core complex and ATR\u2013ATRIP kinase during DNA cross-link repair","volume":"41","author":"Tomida","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2026012104494431800_B42","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1038\/ncomms3338","article-title":"Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs","volume":"4","author":"Takata","year":"2013","journal-title":"Nat Commun"},{"key":"2026012104494431800_B43","doi-asserted-by":"publisher","first-page":"e99543","DOI":"10.15252\/embj.201899543","article-title":"FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells","volume":"37","author":"Tomida","year":"2018","journal-title":"EMBO J"},{"key":"2026012104494431800_B44","doi-asserted-by":"publisher","first-page":"e1004654","DOI":"10.1371\/journal.pgen.1004654","article-title":"Mechanism of suppression of chromosomal instability by DNA polymerase POLQ","volume":"10","author":"Yousefzadeh","year":"2014","journal-title":"PLoS Genet"},{"key":"2026012104494431800_B45","doi-asserted-by":"publisher","first-page":"108775","DOI":"10.1016\/j.celrep.2021.108775","article-title":"Disruption of DNA polymerase zeta engages an innate immune response","volume":"34","author":"Martin","year":"2021","journal-title":"Cell Rep"},{"key":"2026012104494431800_B46","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"2026012104494431800_B47","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S0960-9822(03)00376-2","article-title":"ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation","volume":"13","author":"Barr","year":"2003","journal-title":"Curr Biol"},{"key":"2026012104494431800_B48","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S1097-2765(03)00099-6","article-title":"A p53-dependent checkpoint pathway prevents rereplication","volume":"11","author":"Vaziri","year":"2003","journal-title":"Mol Cell"},{"key":"2026012104494431800_B49","doi-asserted-by":"publisher","first-page":"12105","DOI":"10.1038\/ncomms12105","article-title":"A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis","volume":"7","author":"Gao","year":"2016","journal-title":"Nat Commun"},{"key":"2026012104494431800_B50","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1083\/jcb.201702006","article-title":"DNA repair factor RAD18 and DNA polymerase Polkappa confer tolerance of oncogenic DNA replication stress","volume":"216","author":"Yang","year":"2017","journal-title":"J Cell Biol"},{"key":"2026012104494431800_B51","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat Methods"},{"key":"2026012104494431800_B52","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"2026012104494431800_B53","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.tcb.2021.04.002","article-title":"REV7: jack of many trades","volume":"31","author":"de\u00a0Krijger","year":"2021","journal-title":"Trends Cell Biol"},{"key":"2026012104494431800_B54","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1101\/gad.1666208","article-title":"TopBP1 activates ATR through ATRIP and a PIKK regulatory domain","volume":"22","author":"Mordes","year":"2008","journal-title":"Genes Dev"},{"key":"2026012104494431800_B55","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.1158\/0008-5472.CAN-12-0523","article-title":"Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1","volume":"72","author":"Wang","year":"2012","journal-title":"Cancer Res"},{"key":"2026012104494431800_B56","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1128\/MCB.01611-06","article-title":"Specific role of Chk1 phosphorylations in cell survival and checkpoint activation","volume":"27","author":"Niida","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2026012104494431800_B57","doi-asserted-by":"publisher","first-page":"14806","DOI":"10.1074\/jbc.M210862200","article-title":"Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation","volume":"278","author":"Gatei","year":"2003","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B58","doi-asserted-by":"publisher","first-page":"22343","DOI":"10.1074\/jbc.M501562200","article-title":"DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint","volume":"280","author":"Bi","year":"2005","journal-title":"J Biol Chem"},{"key":"2026012104494431800_B59","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1128\/MCB.26.9.3527-3540.2006","article-title":"Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest","volume":"26","author":"Bi","year":"2006","journal-title":"Mol Cell Biol"},{"key":"2026012104494431800_B60","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/cr.2017.158","article-title":"Cryo-EM structure of human ATR\u2013ATRIP complex","volume":"28","author":"Rao","year":"2018","journal-title":"Cell Res"},{"key":"2026012104494431800_B61","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.1038\/s41467-022-32861-5","article-title":"MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner","volume":"13","author":"Paniagua","year":"2022","journal-title":"Nat Commun"},{"key":"2026012104494431800_B62","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1101\/gad.187501","article-title":"Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells","volume":"15","author":"Kannouche","year":"2001","journal-title":"Genes Dev"},{"key":"2026012104494431800_B63","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1046\/j.1523-1747.2000.00154.x","article-title":"Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation","volume":"115","author":"Itoh","year":"2000","journal-title":"J Invest Dermatol"},{"key":"2026012104494431800_B64","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1093\/hmg\/ddq046","article-title":"ATR\/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells","volume":"19","author":"Despras","year":"2010","journal-title":"Hum Mol Genet"},{"key":"2026012104494431800_B65","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/2\/gkaf1527\/66501118\/gkaf1527.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/2\/gkaf1527\/66501118\/gkaf1527.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:49:57Z","timestamp":1768988997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkaf1527\/8433884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,14]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaf1527","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,27]]},"published":{"date-parts":[[2026,1,14]]},"article-number":"gkaf1527"}}