{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:08:44Z","timestamp":1793074124816,"version":"4.5.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"W1","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008383","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002957","name":"TU Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>PLIP, the protein\u2013ligand\u00a0interaction profiler, analyses molecular interactions in protein structures. PLIP detects eight types of non-covalent interactions. Initially focused on small-molecule, DNA, and RNA interactions to a protein, the current release incorporates protein\u2013protein interactions. We document the usefulness of this feature by comparing PLIP interactions of the cancer drug venetoclax with the native protein\u2013protein interaction of Bcl-2 and BAX. PLIP reveals how the drug mimics the native interaction, as there is critical overlap in the interaction profiles. PLIP is available as a web server, source code with containers, and Jupyter notebook. The PLIP web server is online at https:\/\/plip-tool.biotec.tu-dresden.de.<\/jats:p>","DOI":"10.1093\/nar\/gkaf361","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:14:39Z","timestamp":1746778479000},"page":"W463-W465","source":"Crossref","is-referenced-by-count":375,"title":["PLIP 2025: introducing protein\u2013protein interactions to the protein\u2013ligand interaction profiler"],"prefix":"10.1093","volume":"53","author":[{"given":"Philipp","family":"Schake","sequence":"first","affiliation":[{"name":"Biotec and scads.ai, TU Dresden , 01307\u00a0Dresden,\u00a0","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Naomi","family":"Bolz","sequence":"additional","affiliation":[{"name":"Biotec and scads.ai, TU Dresden , 01307\u00a0Dresden,\u00a0","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Linnemann","sequence":"additional","affiliation":[{"name":"Biotec 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