{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:12:13Z","timestamp":1783458733345,"version":"3.55.0"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kimmelman Center for Macromolecular Assemblies"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI119788"],"award-info":[{"award-number":["AI119788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Programme Excellence Initiative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Porphyromonas gingivalis, an anaerobic pathogen in chronic periodontitis, belongs to the Bacteroidota phylum and is associated with various virulence factors. Its antibiotic-resistant strains and its propensity to form biofilms pose a challenge to effective treatment. To explore therapeutic avenues, we studied the high-resolution cryogenic\u00a0electron microscope structures of ribosomes from the wild-type P. gingivalis W83 and the macrolide-resistant mutant strain erm\u0394porN. The structural analysis revealed unique features primarily at the ribosome periphery. Together with the distinctive distribution of ribosomal\u00a0RNA modifications, these findings offer insights into the therapeutical potential, such as creation of novel therapeutic compounds inhibiting the specific cellular functions of the P. gingivalis ribosomes. Moreover, the high-resolution structure of the erm\u0394porN ribosome in its complex with the approved antibiotic lefamulin suggests its repurposing against P. gingivalis. Furthermore, we provide a foundation for additional effective strategies to treat periodontitis and associated systemic diseases.<\/jats:p>","DOI":"10.1093\/nar\/gkaf458","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:42:52Z","timestamp":1748598172000},"source":"Crossref","is-referenced-by-count":5,"title":["Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen <i>Porphyromonas gingivalis<\/i>"],"prefix":"10.1093","volume":"53","author":[{"given":"Disha-Gajanan","family":"Hiregange","sequence":"first","affiliation":[{"name":"Weizmann Institute of Science Department of Chemical and Structural Biology, , Rehovot 7610001 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit","family":"Samiya","sequence":"additional","affiliation":[{"name":"Weizmann Institute of Science Department of Chemical and Structural Biology, , Rehovot 7610001 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