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The ultra-long telomeres of the house mouse hinder its utility as a model for telomere-related diseases. We have previously generated a mouse model with human-length telomeres, termed \u201cTelomouse,\u201d\u00a0by substituting methionine 492 of mouse Rtel1 to a lysine (Rtel1M492K). In humans, a methionine to isoleucine mutation at this position causes the\u00a0fatal telomere biology disorder Hoyeraal-Hreidarsson syndrome (HHS). Here, we introduced the Rtel1M492I point mutation into the mouse genome, generating another mouse model, which we termed \u201cHHS mouse.\u201d\u00a0The HHS mouse telomeres are not as short as those of the Telomouse but nevertheless display higher levels of telomeric DNA damage, fragility, and recombination, associated with anaphase bridges and micronuclei. The HHS mouse also exhibits aberrant hematopoiesis and pre-fibrotic alterations in the lung. These observations indicate that the\u00a0two mutations at the same codon separate critical functions of RTEL1: Rtel1M492K mainly reduces the telomere length setpoint, while Rtel1M492I predominantly disrupts telomere protection. The two mouse models enable dissecting the mechanistic roles of RTEL1 and the different contributions of short telomeres and DNA damage to telomere biology disorders and genomic instability.<\/jats:p>","DOI":"10.1093\/nar\/gkaf507","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:44:32Z","timestamp":1748504672000},"source":"Crossref","is-referenced-by-count":3,"title":["Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9798","authenticated-orcid":false,"given":"Riham","family":"Smoom","sequence":"first","affiliation":[{"name":"The Silberman Institute of Life Sciences, Safra Campus, The Hebrew University of Jerusalem Department of Genetics, , Jerusalem 91904 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