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Eukaryotic organisms display intricate transcriptional regulation influenced by chromatin structures and histone modifications. Set1-mediated methylation of histone H3 at lysine 4 (H3K4) is a well-established marker of active transcription in eukaryotes. However, the deletion of Set1 in the dimorphic pathogenic fungus, Candida albicans, led to the activation of signal-responsive genes even in the absence of external signals. The present study aimed to elucidate Set1\u2019s role in the transcription of genes that respond to external signals. These inducible genes displayed atypical H3K4 modification patterns. During the initial induction stages, H3K4 methylation was not involved in the rapid and robust expression of these genes; instead, acetylation of the same residue was involved. H3K4 acetylation significantly increased in the absence of H3K4 methylation, allowing genes that did not receive external transcriptional signals to initiate mRNA expression, leading to morphological changes. With continued exposure to induction signals, the heightened H3K4 acetylation decreased while H3K4 methylation increased in these genes. Thus, inducible genes receive positive feedback for stable and sustainable expression. In conclusion, Set1 precisely modulates H3K4 methylation and acetylation levels to regulate the transcription of inducible genes at specific times and levels.<\/jats:p>","DOI":"10.1093\/nar\/gkaf632","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T07:36:32Z","timestamp":1750577792000},"source":"Crossref","is-referenced-by-count":3,"title":["Set1 is a critical transcriptional regulator in response to external signals in\n                    <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"53","author":[{"given":"Jueun","family":"Kim","sequence":"first","affiliation":[{"name":"College of Biomedical Science, Kangwon National University Department of Molecular Bioscience, , Chuncheon\u00a0 24341 ,","place":["Republic of Korea"]},{"name":"Institute of Life Sciences, Kangwon National University , Chuncheon\u00a0 24341 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Biomedical Science, Kangwon National University Department of Molecular Bioscience, , Chuncheon\u00a0 24341 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-1974","authenticated-orcid":false,"given":"Eun-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea University Department of Life Sciences, , Seoul\u00a0 02841 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-2670","authenticated-orcid":false,"given":"Yong-Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Biomedical Science, Kangwon National University Department of Molecular Bioscience, , Chuncheon\u00a0 24341 ,","place":["Republic of 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