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Our understanding of plasmid mobility has progressed extensively in the last few decades. Conjugative plasmids are still often the textbook image of plasmids, yet they are now known to represent a minority. Many plasmids are mobilized by other mobile genetic elements, some are mobilized as phages, and others use atypical mechanisms of transfer. This review focuses on recent advances in our understanding of plasmid mobility, from the molecular mechanisms allowing transfer and evolutionary changes of plasmids to the ecological determinants of their spread. In this emerging, extended view of plasmid mobility, interactions between mobile genetic elements, whether involving exploitation, competition, or elimination, affect plasmid transfer and stability. Likewise, interactions between multiple cells and their plasmids shape the latter patterns of transfer through transfer-mediated bacterial predation, interference, or eavesdropping in cell communication, and by deploying defense and antidefense activity. All these processes are relevant for microbiome intervention strategies, from plasmid containment in clinical settings to harnessing plasmids in ecological or industrial interventions.<\/jats:p>","DOI":"10.1093\/nar\/gkaf652","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T19:50:43Z","timestamp":1753213843000},"source":"Crossref","is-referenced-by-count":49,"title":["The extended mobility of plasmids"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-5428","authenticated-orcid":false,"given":"Maria\u00a0Pilar","family":"Garcill\u00e1n-Barcia","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Cantabria) ,\u00a039011 Santander, Cantabria,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-6857","authenticated-orcid":false,"given":"Fernando","family":"de\u00a0la\u00a0Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Cantabria) ,\u00a039011 Santander, Cantabria,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-822X","authenticated-orcid":false,"given":"Eduardo\u00a0P C","family":"Rocha","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3525, Microbial Evolutionary Genomics , 75015\u00a0 Paris 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