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It has also been known to play essential roles in trophoblast development and placentation. Dysregulation of PPARG in trophoblast differentiation has been implicated in pregnancy complications, such as pre-eclampsia and gestational diabetes. However, the molecular mechanisms of PPARG-dependent target gene regulation and its interactions with other regulatory factors during human trophoblast differentiation remain unclear. Using human trophoblast stem cells (TSCs), mimicking placental cytotrophoblasts (CTs), and their differentiation into extravillous trophoblasts (EVTs) as our models, we reveal that PPARG has cell-type-specific targets in TSCs and EVTs. We also find that while PPARG is essential for both TSC self-renewal and EVT differentiation, only its role in EVT differentiation is ligand\u00a0sensitive and requires ligand-binding domain (LBD)-mediated transcriptional activity, whereas its function in TSC self-renewal appears to be\u00a0ligand\u00a0insensitive. Combined analysis with chromosomal targets of previously defined key TFs in TSCs and EVTs shows that PPARG forms trophoblast cell-type-specific regulatory circuitries, leading to differential target gene regulation via transcriptional re-wiring during EVT differentiation. Additionally, the enhanced invasiveness of EVTs treated with a PPARG agonist suggests a potential connection between PPARG pathways and human placenta accreta.<\/jats:p>","DOI":"10.1093\/nar\/gkaf669","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:49:29Z","timestamp":1753271369000},"source":"Crossref","is-referenced-by-count":8,"title":["PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts"],"prefix":"10.1093","volume":"53","author":[{"given":"Qingqing","family":"Guo","sequence":"first","affiliation":[{"name":"The University of Texas at Austin Department of Molecular Biosciences, , Austin , TX\u00a0 78712 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonhyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin Department of Molecular Biosciences, , Austin , TX\u00a0 78712 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin Department of Molecular Biosciences, , Austin , TX\u00a0 78712 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-9843","authenticated-orcid":false,"given":"Jonghwan","family":"Kim","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin Department of Molecular Biosciences, , Austin , TX\u00a0 78712 ,","place":["United States"]},{"name":"Center for Systems and Synthetic Biology, The University of Texas at Austin , Austin , TX\u00a0 78712 ,","place":["United 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