{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:38:09Z","timestamp":1790818689234,"version":"4.1.0"},"reference-count":134,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR34522\/MED\/31\/417\/2019"],"award-info":[{"award-number":["BT\/PR34522\/MED\/31\/417\/2019"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005808","name":"IIT Bombay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005808","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CSIR fellowship","award":["09\/087(0927)\/2017-EMR-I"],"award-info":[{"award-number":["09\/087(0927)\/2017-EMR-I"]}]},{"name":"Madhuri Sinha Chair Professorship funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Embryonic stem cells (ESCs), which are susceptible to DNA damage, depend on a robust and highly efficient DNA damage response (DDR) mechanism for their survival. However, the implications of physical force-mediated DNA damage on ESC fate remain unclear. We show that stiffness-dependent spreading of mouse ESCs (mESCs) induces DNA damage through nuclear compression, with DNA damage causing differentiation through Lamin A\/C. Interestingly, differentiation is associated with DNA damage and activation of the DDR factors such as ATR and CHK1. While ATR is typically known to play roles in DDR pathway, its role during stiffness-mediated nuclear compression and mESC differentiation is unknown. While our results show activation of CHK1 pathway and nuclear enrichment of activated ATR on stiff substrates, inhibiting ATR and CHK1 both result in reduction of Lamin A\/C expression by different mechanisms. Overall, we demonstrate that mESC differentiation is driven by nuclear compression-mediated DNA damage and involves ATR-dependent modulation of Lamin A\/C.<\/jats:p>","DOI":"10.1093\/nar\/gkaf852","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:45:27Z","timestamp":1757418327000},"source":"Crossref","is-referenced-by-count":5,"title":["Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7042-8557","authenticated-orcid":false,"given":"Tanusri","family":"Roy","sequence":"first","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7469-9830","authenticated-orcid":false,"given":"Swetlana","family":"Ghosh","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6032-0730","authenticated-orcid":false,"given":"Niyati","family":"Piplani","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-3505","authenticated-orcid":false,"given":"Lakshmi\u00a0Kavitha","family":"Sthanam","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1855-0464","authenticated-orcid":false,"given":"Niharika","family":"Tiwary","sequence":"additional","affiliation":[{"name":"Centre for Cellular and Molecular Biology , Hyderabad 500007 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7142-7289","authenticated-orcid":false,"given":"Sayak","family":"Dhar","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-1489","authenticated-orcid":false,"given":"W\u00a0Chingmei\u00a0Wangsa","family":"Konyak","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3933-2504","authenticated-orcid":false,"given":"Santosh\u00a0Surendra","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-2937","authenticated-orcid":false,"given":"Priya","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre for Cellular and Molecular Biology , Hyderabad 500007 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-6011","authenticated-orcid":false,"given":"Divya\u00a0Tej","family":"Sowpati","sequence":"additional","affiliation":[{"name":"Centre for Cellular and Molecular Biology , Hyderabad 500007 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-339X","authenticated-orcid":false,"given":"Sreelaja","family":"Nair","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-745X","authenticated-orcid":false,"given":"Sushil","family":"Kumar","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-2105","authenticated-orcid":false,"given":"P\u00a0Chandra","family":"Shekar","sequence":"additional","affiliation":[{"name":"Centre for Cellular and Molecular Biology , Hyderabad 500007 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-8659","authenticated-orcid":false,"given":"Shamik","family":"Sen","sequence":"additional","affiliation":[{"name":"IIT Bombay Department of Biosciences & Bioengineering, , Mumbai 400076,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"2025102300120831600_B1","doi-asserted-by":"publisher","first-page":"7634","DOI":"10.1073\/pnas.78.12.7634","article-title":"Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells","volume":"78","author":"Martin","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025102300120831600_B2","doi-asserted-by":"publisher","first-page":"6940283","DOI":"10.1155\/2016\/6940283","article-title":"Stem Cells Applications in Regenerative Medicine and Disease Therapeutics","volume":"2016","author":"Mahla","year":"2016","journal-title":"Int J Cell Biol"},{"key":"2025102300120831600_B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/jcp.24104","article-title":"The abbreviated pluripotent cell cycle","volume":"228","author":"Kapinas","year":"2013","journal-title":"J Cell Physiol"},{"key":"2025102300120831600_B4","doi-asserted-by":"publisher","first-page":"10660","DOI":"10.1038\/ncomms10660","article-title":"A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells","volume":"7","author":"Ahuja","year":"2016","journal-title":"Nat Commun"},{"key":"2025102300120831600_B5","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.molcel.2017.04.006","article-title":"DNA damage in stem cells","volume":"66","author":"Vitale","year":"2017","journal-title":"Mol Cell"},{"key":"2025102300120831600_B6","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"2025102300120831600_B7","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.4161\/cc.9.24.14323","article-title":"ATM activation in the presence of oxidative stress","volume":"9","author":"Guo","year":"2010","journal-title":"Cell Cycle"},{"key":"2025102300120831600_B8","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.cmet.2006.10.002","article-title":"ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome","volume":"4","author":"Schneider","year":"2006","journal-title":"Cell Metab"},{"key":"2025102300120831600_B9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tibs.2011.10.002","article-title":"The ATM protein kinase and cellular redox signaling: beyond the DNA damage response","volume":"37","author":"Ditch","year":"2012","journal-title":"Trends Biochem Sci"},{"key":"2025102300120831600_B10","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"2025102300120831600_B11","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"2025102300120831600_B12","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2009.01.024","article-title":"Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks","volume":"33","author":"Shiotani","year":"2009","journal-title":"Mol Cell"},{"key":"2025102300120831600_B13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes & Dev"},{"key":"2025102300120831600_B14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.stem.2007.03.002","article-title":"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss","volume":"1","author":"Ruzankina","year":"2007","journal-title":"Cell Stem Cell"},{"key":"2025102300120831600_B15","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.cell.2008.01.038","article-title":"Stem cells and niches: mechanisms that promote stem cell maintenance throughout life","volume":"132","author":"Morrison","year":"2008","journal-title":"Cell"},{"key":"2025102300120831600_B16","doi-asserted-by":"publisher","first-page":"879379","DOI":"10.1155\/2018\/4879379","article-title":"The stem cell niche: interactions between stem cells and their environment","volume":"2018","author":"Pennings","year":"2018","journal-title":"Stem Cells International"},{"key":"2025102300120831600_B17","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1242\/dev.002022","article-title":"Stem cells and their niche: an inseparable relationship","volume":"134","author":"Xie","year":"2007","journal-title":"Development"},{"key":"2025102300120831600_B18","doi-asserted-by":"publisher","DOI":"10.5772\/62671","article-title":"Pluripotent stem cells and their dynamic niche","volume-title":"Pluripotent Stem Cells - From the Bench to the Clinic","author":"Reinwald","year":"2016"},{"key":"2025102300120831600_B19","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"2025102300120831600_B20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1021\/acsbiomaterials.8b00313","article-title":"Initial priming on soft substrates enhances subsequent topography-induced neuronal differentiation in ESCs but not in MSCs","volume":"5","author":"Sthanam","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"2025102300120831600_B21","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.3390\/ijms22063178","article-title":"Regulation of nuclear mechanics and the impact on DNA damage","volume":"22","author":"Dos","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025102300120831600_B22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.tcb.2017.02.008","article-title":"Bursting the bubble \u2013 nuclear envelope rupture as a path to genomic instability?","volume":"27","author":"Shah","year":"2017","journal-title":"Trends in Cell Biology"},{"key":"2025102300120831600_B23","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.bpj.2012.10.015","article-title":"Chromatin decondensation and nuclear softening accompany nanog downregulation in embryonic stem cells","volume":"103","author":"Chalut","year":"2012","journal-title":"Biophys J"},{"key":"2025102300120831600_B24","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nmat3943","article-title":"Auxetic nuclei in embryonic stem cells exiting pluripotency","volume":"13","author":"Pagliara","year":"2014","journal-title":"Nat Mater"},{"key":"2025102300120831600_B25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/978-1-4899-8032-8_17","article-title":"DNA damage and lamins","volume":"773","author":"Gonzalo","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"2025102300120831600_B26","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1038\/emboj.2009.196","article-title":"Novel roles for A-type lamins in telomere biology and the DNA damage response pathway","volume":"28","author":"Gonzalez-Suarez","year":"2009","journal-title":"EMBO J"},{"key":"2025102300120831600_B27","doi-asserted-by":"publisher","first-page":"101301","DOI":"10.1016\/j.jbc.2021.101301","article-title":"Lamin A\/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability","volume":"297","author":"Graziano","year":"2021","journal-title":"J Biol Chem"},{"key":"2025102300120831600_B28","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/acel.12258","article-title":"Lamin A\/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage","volume":"14","author":"Gibbs-Seymour","year":"2015","journal-title":"Aging Cell"},{"key":"2025102300120831600_B29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s13105-019-00661-z","article-title":"The role of lamin A\/C in mesenchymal stem cell differentiation","volume":"75","author":"Zhang","year":"2019","journal-title":"J Physiol Biochem"},{"key":"2025102300120831600_B30","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1172\/JCI200419670","article-title":"Lamin A\/C deficiency causes defective nuclear mechanics and mechanotransduction","volume":"113","author":"Lammerding","year":"2004","journal-title":"J Clin Invest"},{"key":"2025102300120831600_B31","doi-asserted-by":"publisher","first-page":"1240104","DOI":"10.1126\/science.1240104","article-title":"Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation","volume":"341","author":"Swift","year":"2013","journal-title":"Science"},{"key":"2025102300120831600_B32","doi-asserted-by":"publisher","first-page":"e57891","DOI":"10.1371\/journal.pone.0057891","article-title":"Lamin A\/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cells","volume":"8","author":"Sehgal","year":"2013","journal-title":"PLoS One"},{"key":"2025102300120831600_B33","doi-asserted-by":"publisher","first-page":"6663","DOI":"10.1038\/s41467-022-34366-7","article-title":"Lamin A\/C-dependent chromatin architecture safeguards na\u00efve pluripotency to prevent aberrant cardiovascular cell fate and function","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"2025102300120831600_B34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/1043-4682(92)90026-R","article-title":"Assembly and cell cycle dynamics of the nuclear lamina","volume":"3","author":"Nigg","year":"1992","journal-title":"Semin Cell Biol"},{"key":"2025102300120831600_B35","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.bbamcr.2006.07.008","article-title":"Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress","volume":"1763","author":"Nakamura","year":"2006","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2025102300120831600_B36","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/978-1-4899-8032-8_19","article-title":"Nuclear lamins and oxidative stress in cell proliferation and longevity","volume-title":"Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology","author":"Shimi","year":"2014"},{"key":"2025102300120831600_B37","doi-asserted-by":"publisher","first-page":"259788","DOI":"10.1242\/jcs.259788","article-title":"Lamin A\/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress","volume":"136","author":"Virtanen","year":"2023","journal-title":"J Cell Sci"},{"key":"2025102300120831600_B38","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.cub.2014.07.001","article-title":"Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin","volume":"24","author":"Buxboim","year":"2014","journal-title":"Curr Biol"},{"key":"2025102300120831600_B39","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.matbio.2019.01.001","article-title":"Nuclear softening is essential for protease-independent migration","volume":"82","author":"Das","year":"2019","journal-title":"Matrix Biol"},{"key":"2025102300120831600_B40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1083\/jcb.201609102","article-title":"Nuclear envelope rupture: actin fibers are putting the squeeze on the nucleus","volume":"215","author":"Lammerding","year":"2016","journal-title":"J Cell Biol"},{"key":"2025102300120831600_B41","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1091\/mbc.E16-02-0098","article-title":"Nuclear envelope rupture drives genome instability in cancer","volume":"27","author":"Lim","year":"2016","journal-title":"Mol Biol Cell"},{"key":"2025102300120831600_B42","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.aad7297","article-title":"Nuclear envelope rupture and repair during cancer cell migration","volume":"352","author":"Denais","year":"2016","journal-title":"Science"},{"key":"2025102300120831600_B43","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1038\/s41467-020-18580-9","article-title":"ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration","volume":"11","author":"Kidiyoor","year":"2020","journal-title":"Nat Commun"},{"key":"2025102300120831600_B44","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2014.05.046","article-title":"ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress","volume":"158","author":"Kumar","year":"2014","journal-title":"Cell"},{"key":"2025102300120831600_B45","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1038\/s41467-021-24131-7","article-title":"The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation","volume":"12","author":"Li","year":"2021","journal-title":"Nat Commun"},{"key":"2025102300120831600_B46","doi-asserted-by":"publisher","first-page":"113555","DOI":"10.1016\/j.celrep.2023.113555","article-title":"Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin","volume":"42","author":"Bastianello","year":"2023","journal-title":"Cell Rep"},{"key":"2025102300120831600_B47","doi-asserted-by":"publisher","first-page":"875132","DOI":"10.3389\/fcell.2022.875132","article-title":"ATM modulates nuclear mechanics by regulating lamin A levels","volume":"10","author":"Shah","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2025102300120831600_B48","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.biomaterials.2016.12.006","article-title":"Biophysical regulation of mouse embryonic stem cell fate and genomic integrity by feeder derived matrices","volume":"119","author":"Sthanam","year":"2017","journal-title":"Biomaterials"},{"key":"2025102300120831600_B49","doi-asserted-by":"publisher","first-page":"10660","DOI":"10.1038\/ncomms10660","article-title":"A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells","volume":"7","author":"Ahuja","year":"2016","journal-title":"Nat Commun"},{"key":"2025102300120831600_B50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/0471143030.cb1016s47","article-title":"Preparation of hydrogel substrates with tunable mechanical properties","volume":"47","author":"Tse","year":"2010","journal-title":"Curr Protoc Cell Biol"},{"key":"2025102300120831600_B51","doi-asserted-by":"publisher","first-page":"14219","DOI":"10.1038\/s41598-017-14340-w","article-title":"MMP proteolytic activity regulates cancer invasiveness by modulating integrins","volume":"7","author":"Das","year":"2017","journal-title":"Sci Rep"},{"key":"2025102300120831600_B52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/978-1-62703-056-4","volume-title":"Cell Imaging Techniques","author":"Mackay","year":"2013"},{"key":"2025102300120831600_B53","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.4161\/cc.7.18.6699","article-title":"Activation of DNA damage response signaling in mouse embryonic stem cells","volume":"7","author":"Chuykin","year":"2008","journal-title":"Cell Cycle"},{"key":"2025102300120831600_B54","doi-asserted-by":"publisher","first-page":"9677","DOI":"10.1074\/jbc.C300554200","article-title":"UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress","volume":"279","author":"Ward","year":"2004","journal-title":"J Biol Chem"},{"key":"2025102300120831600_B55","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.yexcr.2008.12.007","article-title":"Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells","volume":"315","author":"Ban\u00e1th","year":"2009","journal-title":"Exp Cell Res"},{"key":"2025102300120831600_B56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1160\/TH03-11-0728","article-title":"Manganese-induced integrin affinity maturation promotes recruitment of \u03b1V\u03b23 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src","volume":"92","author":"Dormond","year":"2004","journal-title":"Thromb Haemost"},{"key":"2025102300120831600_B57","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1083\/jcb.200503017","article-title":"The mechanisms and dynamics of \u03b1v\u03b23 integrin clustering in living cells","volume":"171","author":"Cluzel","year":"2005","journal-title":"J Cell Biol"},{"key":"2025102300120831600_B58","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1038\/s41467-022-30117-w","article-title":"Mechanism of integrin activation by talin and its cooperation with kindlin","volume":"13","author":"Lu","year":"2022","journal-title":"Nat Commun"},{"key":"2025102300120831600_B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22203\/eCM.v018a01","article-title":"Substrate stiffness affects early differentiation events in embryonic stem cells","volume":"18","author":"Evans","year":"2009","journal-title":"Eur Cell Mater"},{"key":"2025102300120831600_B60","doi-asserted-by":"publisher","first-page":"e15655","DOI":"10.1371\/journal.pone.0015655","article-title":"Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions","volume":"5","author":"Chowdhury","year":"2010","journal-title":"PLoS One"},{"key":"2025102300120831600_B61","doi-asserted-by":"publisher","first-page":"121268","DOI":"10.1016\/j.biomaterials.2021.121268","article-title":"MMP modulated differentiation of mouse embryonic stem cells on engineered cell derived matrices","volume":"280","author":"Sthanam","year":"2022","journal-title":"Biomaterials"},{"key":"2025102300120831600_B62","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","article-title":"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4","volume":"95","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"2025102300120831600_B63","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/74199","article-title":"Quantitative expression of Oct-3\/4 defines differentiation, dedifferentiation or self-renewal of ES cells","volume":"24","author":"Niwa","year":"2000","journal-title":"Nat Genet"},{"key":"2025102300120831600_B64","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1101\/gad.224503","article-title":"Multipotent cell lineages in early mouse development depend on SOX2 function","volume":"17","author":"Avilion","year":"2003","journal-title":"Genes Dev"},{"key":"2025102300120831600_B65","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","article-title":"The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells","volume":"113","author":"Mitsui","year":"2003","journal-title":"Cell"},{"key":"2025102300120831600_B66","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0092-8674(03)00392-1","article-title":"Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells","volume":"113","author":"Chambers","year":"2003","journal-title":"Cell"},{"key":"2025102300120831600_B67","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1182\/blood-2004-07-2681","article-title":"Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4","volume":"105","author":"Li","year":"2005","journal-title":"Blood"},{"key":"2025102300120831600_B68","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/dvdy.21437","article-title":"Genetic targeting of the endoderm with claudin-6CreER","volume":"237","author":"Anderson","year":"2008","journal-title":"Dev Dyn"},{"key":"2025102300120831600_B69","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1242\/dmm.002634","article-title":"Involucrin\u2013claudin-6 tail deletion mutant (C\u0394206) transgenic mice: a model of delayed epidermal permeability barrier formation and repair","volume":"3","author":"Enikanolaiye","year":"2010","journal-title":"Dis Model Mech"},{"key":"2025102300120831600_B70","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1242\/dev.121.11.3877","article-title":"Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro","volume":"121","author":"Soudais","year":"1995","journal-title":"Development"},{"key":"2025102300120831600_B71","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.devcel.2009.05.012","article-title":"Sox17 regulates organ lineage segregation of ventral foregut progenitor cells","volume":"17","author":"Spence","year":"2009","journal-title":"Dev Cell"},{"key":"2025102300120831600_B72","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1128\/MCB.17.7.3817","article-title":"Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells","volume":"17","author":"Levinson-Dushnik","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2025102300120831600_B73","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/nature03649","article-title":"The initiation of liver development is dependent on Foxa transcription factors","volume":"435","author":"Lee","year":"2005","journal-title":"Nature"},{"key":"2025102300120831600_B74","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/35624","article-title":"Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6","volume":"391","author":"Chapman","year":"1998","journal-title":"Nature"},{"key":"2025102300120831600_B75","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature09729","article-title":"Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells","volume":"470","author":"Takemoto","year":"2011","journal-title":"Nature"},{"key":"2025102300120831600_B76","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1093\/nar\/15.8.3439","article-title":"The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern","volume":"15","author":"Thisse","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"2025102300120831600_B77","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/dvdy.20047","article-title":"Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells","volume":"230","author":"Ota","year":"2004","journal-title":"Dev Dyn"},{"key":"2025102300120831600_B78","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1006\/dbio.2002.0699","article-title":"Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo","volume":"247","author":"Soo","year":"2002","journal-title":"Dev Biol"},{"key":"2025102300120831600_B79","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.1073\/pnas.0602234103","article-title":"Snail family genes are required for left\u2013right asymmetry determination, but not neural crest formation, in mice","volume":"103","author":"Murray","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025102300120831600_B80","doi-asserted-by":"publisher","first-page":"6426","DOI":"10.1093\/emboj\/18.22.6426","article-title":"The mesoderm determinant Snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis","volume":"18","author":"Ashraf","year":"1999","journal-title":"EMBO J"},{"key":"2025102300120831600_B81","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00441-003-0848-4","article-title":"Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours","volume":"316","author":"Lobo","year":"2004","journal-title":"Cell Tissue Res"},{"key":"2025102300120831600_B82","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.stemcr.2015.01.008","article-title":"Use of RUNX2 expression to identify osteogenic progenitor cells derived from human embryonic stem cells","volume":"4","author":"Zou","year":"2015","journal-title":"Stem Cell Rep"},{"key":"2025102300120831600_B83","doi-asserted-by":"publisher","first-page":"e108747","DOI":"10.15252\/embj.2021108747","article-title":"Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo","volume":"41","author":"Nahaboo","year":"2022","journal-title":"EMBO J"},{"key":"2025102300120831600_B84","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/dvdy.20408","article-title":"Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development","volume":"233","author":"Kemp","year":"2005","journal-title":"Dev Dyn"},{"key":"2025102300120831600_B85","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1242\/dev.038828","article-title":"Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2","volume":"137","author":"Ralston","year":"2010","journal-title":"Development"},{"key":"2025102300120831600_B86","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1126\/science.aad7611","article-title":"ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death","volume":"352","author":"Raab","year":"2016","journal-title":"Science"},{"key":"2025102300120831600_B87","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.devcel.2019.04.020","article-title":"Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest","volume":"49","author":"Cho","year":"2019","journal-title":"Dev Cell"},{"key":"2025102300120831600_B88","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.devcel.2020.10.015","article-title":"Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells","volume":"55","author":"Muncie","year":"2020","journal-title":"Dev Cell"},{"key":"2025102300120831600_B89","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41586-018-0762-2","article-title":"Mechanosignalling via integrins directs fate decisions of pancreatic progenitors","volume":"564","author":"Mamidi","year":"2018","journal-title":"Nature"},{"key":"2025102300120831600_B90","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1016\/j.bbagen.2012.09.001","article-title":"DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity","volume":"1830","author":"Nagaria","year":"2013","journal-title":"BBA-gen"},{"key":"2025102300120831600_B91","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/ncb1211","article-title":"53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression","volume":"7","author":"Lin","year":"2005","journal-title":"Nat Cell Biol"},{"key":"2025102300120831600_B92","doi-asserted-by":"publisher","first-page":"5842","DOI":"10.1074\/jbc.M610464200","article-title":"Regulation of apoptosis and differentiation by p53 in human embryonic stem cells","volume":"282","author":"Qin","year":"2007","journal-title":"J Biol Chem"},{"key":"2025102300120831600_B93","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/j.yexcr.2008.02.007","article-title":"DNA repair in murine embryonic stem cells and differentiated cells","volume":"314","year":"2009","journal-title":"Exp Cell Res"},{"key":"2025102300120831600_B94","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1146\/annurev-genet-110711-155646","article-title":"Uncovering the molecular and cellular mechanisms of heart development using the zebrafish","volume":"46","author":"Staudt","year":"2012","journal-title":"Annu Rev Genet"},{"key":"2025102300120831600_B95","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1016\/j.molcel.2023.09.023","article-title":"DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A\/C","volume":"83","author":"Kovacs","year":"2023","journal-title":"Mol Cell"},{"key":"2025102300120831600_B96","doi-asserted-by":"publisher","first-page":"6757","DOI":"10.1158\/0008-5472.CAN-13-1002","article-title":"Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells","volume":"73","author":"Khanna","year":"2013","journal-title":"Cancer Res"},{"key":"2025102300120831600_B97","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2014.08.036","article-title":"Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment","volume":"237","author":"Bonello-Palot","year":"2014","journal-title":"Atherosclerosis"},{"key":"2025102300120831600_B98","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nm1266","article-title":"Genomic instability in laminopathy-based premature aging","volume":"11","author":"Liu","year":"2005","journal-title":"Nat Med"},{"key":"2025102300120831600_B99","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/19491034.2018.1454168","article-title":"Causes and consequences of genomic instability in laminopathies: replication stress and interferon response","volume":"9","author":"Graziano","year":"2018","journal-title":"Nucleus"},{"key":"2025102300120831600_B100","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1093\/nar\/gkaa1202","article-title":"DNA damage alters nuclear mechanics through chromatin reorganization","volume":"49","author":"dos","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2025102300120831600_B101","doi-asserted-by":"publisher","first-page":"13374","DOI":"10.1073\/pnas.1903418116","article-title":"An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication","volume":"116","author":"Moiseeva","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025102300120831600_B102","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1128\/MCB.21.13.4129-4139.2001","article-title":"ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1","volume":"21","author":"Zhao","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2025102300120831600_B103","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.tcb.2022.04.010","article-title":"DNA single-strand break repair and human genetic disease","volume":"32","author":"Caldecott","year":"2022","journal-title":"Trends Cell Biol"},{"key":"2025102300120831600_B104","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","article-title":"Endogenous DNA damage as a source of genomic instability in cancer","volume":"68","author":"Tubbs","year":"2017","journal-title":"Cell"},{"key":"2025102300120831600_B105","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol Cell"},{"key":"2025102300120831600_B106","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1634\/stemcells.2007-0103","article-title":"Integrins regulate mouse embryonic stem cell self-renewal","volume":"25","author":"Hayashi","year":"2007","journal-title":"Stem Cells"},{"key":"2025102300120831600_B107","doi-asserted-by":"publisher","first-page":"3422","DOI":"10.1002\/jcp.22697","article-title":"Collagen I regulates the self-renewal of mouse embryonic stem cells through \u03b12\u03b21 integrin- and DDR1-dependent Bmi-1","volume":"226","author":"Suh","year":"2011","journal-title":"J Cell Physiol"},{"key":"2025102300120831600_B108","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/term.2090","article-title":"Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells","volume":"11","author":"Kang","year":"2017","journal-title":"J Tissue Eng Regen Med"},{"key":"2025102300120831600_B109","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2012.138","article-title":"Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions","volume":"20","author":"Brafman","year":"2013","journal-title":"Cell Death Differ"},{"key":"2025102300120831600_B110","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4161\/cam.5.1.13704","article-title":"Fibronectin-mediated upregulation of \u03b15\u03b21 integrin and cell adhesion during differentiation of mouse embryonic stem cells","volume":"5","author":"Pimton","year":"2011","journal-title":"Cell Adh Migr"},{"key":"2025102300120831600_B111","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.1002\/jcp.27518","article-title":"Matrix stiffness modulates the differentiation of neural crest stem cells in vivo","volume":"234","author":"Zhu","year":"2019","journal-title":"J Cell Physiol"},{"key":"2025102300120831600_B112","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.1083\/jcb.201711161","article-title":"Nuclear rupture at sites of high curvature compromises retention of DNA repair factors","volume":"217","author":"Xia","year":"2018","journal-title":"J Cell Biol"},{"key":"2025102300120831600_B113","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cub.2020.11.037","article-title":"Nuclear deformation causes DNA damage by increasing replication stress","volume":"31","author":"Shah","year":"2021","journal-title":"Curr Biol"},{"key":"2025102300120831600_B114","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/ng1023","article-title":"A myogenic differentiation checkpoint activated by genotoxic stress","volume":"32","author":"Puri","year":"2002","journal-title":"Nat Genet"},{"key":"2025102300120831600_B115","doi-asserted-by":"publisher","first-page":"4230","DOI":"10.1073\/pnas.0913089107","article-title":"Caspase 3\/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks","volume":"107","author":"Larsen","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025102300120831600_B116","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/sj.cdd.4400686","article-title":"Morphological and molecular evidence of differentiation during etoposide-induced apoptosis in human lymphoblastoid cells","volume":"7","author":"Ramirez","year":"2000","journal-title":"Cell Death Differ"},{"key":"2025102300120831600_B117","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1242\/jcs.110.3.337","article-title":"Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action","volume":"110","author":"P\u00e9rez","year":"1997","journal-title":"J Cell Sci"},{"key":"2025102300120831600_B118","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3389\/fphar.2018.01307","article-title":"Lowering etoposide doses shifts cell demise from caspase-dependent to differentiation and caspase-3-independent apoptosis via DNA damage response, inducing AML culture extinction","volume":"9","author":"Bruni","year":"2018","journal-title":"Front Pharmacol"},{"key":"2025102300120831600_B119","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1091\/mbc.E19-02-0090","article-title":"Constricted migration modulates stem cell differentiation","volume":"30","author":"Smith","year":"2019","journal-title":"Mol Biol Cell"},{"key":"2025102300120831600_B120","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.bpj.2012.08.041","article-title":"Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transport","volume":"103","author":"Iyer","year":"2012","journal-title":"Biophys J"},{"key":"2025102300120831600_B121","doi-asserted-by":"publisher","first-page":"16895","DOI":"10.1038\/srep16895","article-title":"Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells","volume":"5","author":"Heo","year":"2015","journal-title":"Sci Rep"},{"key":"2025102300120831600_B122","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1073\/pnas.96.6.2846","article-title":"Essential role of STAT3 for embryonic stem cell pluripotency","volume":"96","author":"Raz","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025102300120831600_B123","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/sj.cdd.4401337","article-title":"A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells","volume":"11","author":"Duval","year":"2004","journal-title":"Cell Death Differ"},{"key":"2025102300120831600_B124","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/sj.cdd.4401789","article-title":"Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells","volume":"13","author":"Duval","year":"2006","journal-title":"Cell Death Differ"},{"key":"2025102300120831600_B125","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1634\/stemcells.2006-erratum.2","article-title":"Lamin A\/C expression is a marker of mouse and human embryonic stem cell differentiation","volume":"24","author":"Constantinescu","year":"2006","journal-title":"Stem Cells"},{"key":"2025102300120831600_B126","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4161\/nucl.23384","article-title":"Lamin A\/C is expressed in pluripotent mouse embryonic stem cells","volume":"4","author":"Eckersley-Maslin","year":"2013","journal-title":"Nucleus"},{"key":"2025102300120831600_B127","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.4161\/cc.10.15.16531","article-title":"A dual role for A-type lamins in DNA double-strand break repair","volume":"10","author":"Redwood","year":"2011","journal-title":"Cell Cycle"},{"key":"2025102300120831600_B128","doi-asserted-by":"publisher","first-page":"e61893","DOI":"10.1371\/journal.pone.0061893","article-title":"A-Type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei","volume":"8","author":"Mahen","year":"2013","journal-title":"PLoS One"},{"key":"2025102300120831600_B129","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0960-9822(98)70061-2","article-title":"ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage","volume":"8","author":"Aladjem","year":"1998","journal-title":"Curr Biol"},{"key":"2025102300120831600_B130","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1258\/ebm.2011.011107","article-title":"Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells","volume":"236","author":"Tichy","year":"2011","journal-title":"Exp Biol & Med"},{"key":"2025102300120831600_B131","doi-asserted-by":"publisher","first-page":"108033","DOI":"10.1016\/j.jbc.2024.108033","article-title":"Phosphorylation of Lamin A\/C regulates the structural integrity of the nuclear envelope","volume":"301","author":"Liu","year":"2025","journal-title":"J Biol Chem"},{"key":"2025102300120831600_B132","doi-asserted-by":"publisher","first-page":"102256","DOI":"10.1016\/j.jbc.2022.102256","article-title":"Cyclin-dependent kinase 1 depolymerizes nuclear lamin filaments by disrupting the head-to-tail interaction of the lamin central rod domain","volume":"298","author":"Jeong","year":"2022","journal-title":"J Biol Chem"},{"key":"2025102300120831600_B133","doi-asserted-by":"publisher","first-page":"e56530","DOI":"10.15252\/embr.202256530","article-title":"CHK1-CDC25A-CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos","volume":"24","author":"Knoblochova","year":"2023","journal-title":"EMBO Rep"},{"key":"2025102300120831600_B134","doi-asserted-by":"publisher","first-page":"e54756","DOI":"10.7554\/eLife.54756","article-title":"ATR expands embryonic stem cell fate potential in response to replication stress","volume":"9","author":"Atashpaz","year":"2020","journal-title":"eLife"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/53\/17\/gkaf852\/64870118\/gkaf852.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/53\/17\/gkaf852\/64870118\/gkaf852.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:12:17Z","timestamp":1761192737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkaf852\/8249856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":134,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9,5]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaf852","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.15.585216","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9,23]]},"published":{"date-parts":[[2025,9,5]]},"article-number":"gkaf852"}}