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CIZ1 assemblies influence underlying chromatin, and their disruption alters the expression of autosomal and X-linked gene clusters. Here, we explore the regulated dissolution of CIZ1\u2013Xi assemblies during mitosis and show that, like Xist, CIZ1 is released in prometaphase under the regulation of Aurora Kinase B (AURKB). The part of human\/mouse CIZ1 comprising 179\/181 C-terminal amino acids encodes a matrin-3 domain that facilitates dimerization to form a compact folded core with disordered C-terminal extensions. Mass spectrometry revealed 56 high-confidence interacting partners of the C-terminal fragment, predominantly chromatin, nuclear matrix, and RNA-binding proteins. Phosphomimetic mutation of three conserved AURKB sites in the C-terminal extensions released CIZ1 from its nuclear anchor points, but did not affect its interaction with chromatin or nuclear matrix proteins. In contrast, the same mutations, or deletion of the C-terminal extensions, abolished interaction with RNAs, including Xist. Together, the data suggest CIZ1 is a regulatable component of the protein\u2013RNA assemblies that preserve epigenetic stability across the nucleus, and that AURKB drives their dissolution in mitosis via dissociation of CIZ1 from RNA.<\/jats:p>","DOI":"10.1093\/nar\/gkag018","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:53:33Z","timestamp":1770029613000},"source":"Crossref","is-referenced-by-count":2,"title":["AURKB-driven dissolution of CIZ1\u2013RNA assemblies from the inactive X chromosome in mitosis"],"prefix":"10.1093","volume":"54","author":[{"given":"Lewis","family":"Byrom","sequence":"first","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United Kingdom"]},{"name":"York Biomedical Research Institute, University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle L","family":"Turvey","sequence":"additional","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United Kingdom"]},{"name":"York Biomedical Research Institute, University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-5444","authenticated-orcid":false,"given":"Adam A","family":"Dowle","sequence":"additional","affiliation":[{"name":"Metabolomics and Proteomics Laboratory, York Bioscience Technology Facility, University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United 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University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E","family":"Chapman","sequence":"additional","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United Kingdom"]},{"name":"York Biomedical Research Institute, University of York, York , YO10 5DD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Dickson","sequence":"additional","affiliation":[{"name":"Mammalian cell cycle research group, Department of Biology, University of York, York , YO10 5DD ,","place":["United 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