{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:03:58Z","timestamp":1787735038174,"version":"build-2784847793"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230028"],"award-info":[{"award-number":["32230028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471171"],"award-info":[{"award-number":["32471171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2023A1515010496"],"award-info":[{"award-number":["2023A1515010496"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2023B1515120027"],"award-info":[{"award-number":["2023B1515120027"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Special Support Plan for Young Top-notch Talents","award":["2024TQ08A709"],"award-info":[{"award-number":["2024TQ08A709"]}]},{"name":"Talents\u2019 plan Foundation of Guangdong Second Provincial General Hospital","award":["2025B007"],"award-info":[{"award-number":["2025B007"]}]},{"name":"Guangdong Second Provincial General Hospital","award":["YY2024-002"],"award-info":[{"award-number":["YY2024-002"]}]},{"name":"Guangdong Second Provincial General Hospital","award":["YY2025-008"],"award-info":[{"award-number":["YY2025-008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RNA G-quadruplexes (rG4s), formed through guanine self-recognition into stacked tetrads, serve as critical regulators of gene expression, yet their comprehensive mapping and dynamic regulation in physiological contexts remain technically challenging. Here, we develop Ultra-low-input rG4-seq (ULI\u2013rG4-seq), enabling precise rG4 detection enabling precise rG4 detection with \u223c140 bp resolution in samples as small as 100 oocytes, and reveal notable enrichment of rG4s near crucial regulatory regions, particularly transcription start sites and end sites. This technological advance, combined with Trim-away or oocyte-specific knockout of DHX36 (also known as G4R1 or RHAU), an rG4-specific helicase, reveals acute and chronic loss of DHX36 leads to opposing effects on rG4 levels. This observation extends beyond the traditional view of helicases as unwinding enzymes and suggests sophisticated cellular mechanisms maintaining RNA structural homeostasis. Through integrated analysis of rG4 landscapes and DHX36-binding profiles, we demonstrate coordination between cytoplasmic rG4 regulation and nuclear gene expression, revealing how RNA structure dynamics orchestrate RNA stability and translation, thereby influencing transcriptional elongation, genome stability, and alternative splicing. Finally, we show that deletion of DHX36 resulted in decreased oocyte quality, premature ovarian failure and complete female infertility due to transcriptional defects and genome instability related to R-loop accumulation. These technological and conceptual advances not only deepen our understanding of RNA-based regulation but also open new therapeutic possibilities for diseases involving RNA structure.<\/jats:p>","DOI":"10.1093\/nar\/gkag040","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:26:25Z","timestamp":1768307185000},"source":"Crossref","is-referenced-by-count":3,"title":["Ultra-low-input rG4-seq reveals the RNA G-quadruplex regulome in gene expression and genome integrity"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0256","authenticated-orcid":false,"given":"Tie-Gang","family":"Meng","sequence":"first","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yue","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]},{"name":"Shenyang Normal University, College of Life Science , Shenyang 110034 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-9364","authenticated-orcid":false,"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Bengbu Medical University , Bengbu 233004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongchang","family":"Du","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence, University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tao","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"School of Basic Medical Sciences, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Shan","family":"Ma","sequence":"additional","affiliation":[{"name":"The Affiliated Taian City Central Hospital of Qingdao University , Taian 271000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ni","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Yin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ju","sequence":"additional","affiliation":[{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-894X","authenticated-orcid":false,"given":"Ruibao","family":"Su","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hong","family":"Ou","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-2414","authenticated-orcid":false,"given":"Qing-Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, the Affiliated Guangdong Second Provincial General Hospital of Jinan University , Guangzhou 510317 ,","place":["China"]},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University , Guangzhou 510632 ,","place":["China"]},{"name":"School of Basic Medical Sciences, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026012711191530400_B1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature12756","article-title":"In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features","volume":"505","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"2026012711191530400_B2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41580-024-00748-6","article-title":"Identification of RNA structures and their roles in RNA functions","volume":"25","author":"Cao","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012711191530400_B3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/wrna.1113","article-title":"G-quadruplexes in RNA biology","volume":"3","author":"Millevoi","year":"2012","journal-title":"WIREs RNA"},{"key":"2026012711191530400_B4","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1016\/j.cell.2024.09.037","article-title":"RNA G-quadruplexes form scaffolds that promote neuropathological alpha-synuclein aggregation","volume":"187","author":"Matsuo","year":"2024","journal-title":"Cell"},{"key":"2026012711191530400_B5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature13485","article-title":"RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer","volume":"513","author":"Wolfe","year":"2014","journal-title":"Nature"},{"key":"2026012711191530400_B6","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1021\/jacs.1c00131","article-title":"A helicase unwinds hexanucleotide repeat RNA G-quadruplexes and facilitates repeat-associated non-AUG translation","volume":"143","author":"Liu","year":"2021","journal-title":"J Am Chem Soc"},{"key":"2026012711191530400_B7","doi-asserted-by":"crossref","first-page":"100914","DOI":"10.1016\/j.jbc.2021.100914","article-title":"The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation","volume":"297","author":"Tseng","year":"2021","journal-title":"J Biol Chem"},{"key":"2026012711191530400_B8","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/srep01016","article-title":"C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes","volume":"2","author":"Fratta","year":"2012","journal-title":"Sci Rep"},{"key":"2026012711191530400_B9","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/nmeth.3965","article-title":"rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome","volume":"13","author":"Kwok","year":"2016","journal-title":"Nat Methods"},{"key":"2026012711191530400_B10","doi-asserted-by":"crossref","first-page":"aaf5371","DOI":"10.1126\/science.aaf5371","article-title":"RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria","volume":"353","author":"Guo","year":"2016","journal-title":"Science"},{"key":"2026012711191530400_B11","doi-asserted-by":"crossref","first-page":"a032284","DOI":"10.1101\/cshperspect.a032284","article-title":"Detecting RNA G-quadruplexes (rG4s) in the transcriptome","volume":"10","author":"Kwok","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026012711191530400_B12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nchem.1805","article-title":"Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells","volume":"6","author":"Biffi","year":"2014","journal-title":"Nat Chem"},{"key":"2026012711191530400_B13","doi-asserted-by":"crossref","first-page":"22719","DOI":"10.1038\/srep22719","article-title":"Mechanical insights into ribosomal progression overcoming RNA G-quadruplex from periodical translation suppression in cells","volume":"6","author":"Endoh","year":"2016","journal-title":"Sci Rep"},{"key":"2026012711191530400_B14","first-page":"7421","article-title":"G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA","volume":"48","author":"Simko","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026012711191530400_B15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41586-018-0209-9","article-title":"Structural basis of G-quadruplex unfolding by the DEAH\/RHA helicase DHX36","volume":"558","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"2026012711191530400_B16","doi-asserted-by":"publisher","first-page":"11592","DOI":"10.1093\/nar\/gky861","article-title":"Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts","volume":"46","author":"Herdy","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026012711191530400_B17","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1038\/s41467-019-09802-w","article-title":"RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36","volume":"10","author":"Tippana","year":"2019","journal-title":"Nat Commun"},{"key":"2026012711191530400_B18","doi-asserted-by":"publisher","first-page":"34626","DOI":"10.1074\/jbc.M806277200","article-title":"G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates","volume":"283","author":"Creacy","year":"2008","journal-title":"J Biol Chem"},{"key":"2026012711191530400_B19","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.1093\/nar\/gkr234","article-title":"G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA","volume":"39","author":"Giri","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2026012711191530400_B20","doi-asserted-by":"publisher","first-page":"5043","DOI":"10.1038\/s41467-021-25170-w","article-title":"Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle stem-cell regenerative functions","volume":"12","author":"Chen","year":"2021","journal-title":"Nat Commun"},{"key":"2026012711191530400_B21","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1038\/s41467-019-10432-5","article-title":"DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions","volume":"10","author":"Sauer","year":"2019","journal-title":"Nat Commun"},{"key":"2026012711191530400_B22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1242\/jcs.24.1.167","article-title":"Biochemical studies of mammalian oogenesis: protein synthesis during oocyte growth and meiotic maturation in the mouse","volume":"24","author":"Schultz","year":"1977","journal-title":"J Cell Sci"},{"key":"2026012711191530400_B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2006.01.008","article-title":"Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes","volume":"292","author":"De\u00a0La\u00a0Fuente","year":"2006","journal-title":"Dev Biol"},{"key":"2026012711191530400_B24","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nsmb.3204","article-title":"BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes","volume":"23","author":"Yu","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"2026012711191530400_B25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/bs.ctdb.2015.06.004","article-title":"Sculpting the transcriptome during the oocyte-to-embryo transition in mouse","volume":"113","author":"Svoboda","year":"2015","journal-title":"Curr Top Dev Biol"},{"key":"2026012711191530400_B26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1242\/dev.039487","article-title":"Maternal control of early mouse development","volume":"137","author":"Li","year":"2010","journal-title":"Development"},{"key":"2026012711191530400_B27","doi-asserted-by":"publisher","first-page":"2301940","DOI":"10.1002\/advs.202301940","article-title":"NLRP14 safeguards calcium homeostasis via regulating the K27 ubiquitination of nclx in oocyte-to-embryo transition","volume":"10","author":"Meng","year":"2023","journal-title":"Adv Sci"},{"key":"2026012711191530400_B28","doi-asserted-by":"crossref","first-page":"eabq4835","DOI":"10.1126\/science.abq4835","article-title":"Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment","volume":"378","author":"Cheng","year":"2022","journal-title":"Science"},{"key":"2026012711191530400_B29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41556-021-00696-9","article-title":"Global profiling of RNA-binding protein target sites by LACE-seq","volume":"23","author":"Su","year":"2021","journal-title":"Nat Cell Biol"},{"key":"2026012711191530400_B30","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1182\/blood-2011-08-362954","article-title":"The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis","volume":"119","author":"Lai","year":"2012","journal-title":"Blood"},{"key":"2026012711191530400_B31","doi-asserted-by":"crossref","first-page":"mjac069","DOI":"10.1093\/jmcb\/mjac069","article-title":"DNA\/RNA helicase DHX36 is required for late stages of spermatogenesis","volume":"14","author":"Zhang","year":"2022","journal-title":"J Mol Cell Biol"},{"key":"2026012711191530400_B32","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/cr.2017.117","article-title":"Mettl3-\/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis","volume":"27","author":"Lin","year":"2017","journal-title":"Cell Res"},{"key":"2026012711191530400_B33","first-page":"98","article-title":"The development of the mouse ovary from birth to maturity","volume":"62","author":"Peters","year":"1969","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2026012711191530400_B34","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1038\/s41467-018-07224-8","article-title":"Transcriptome-wide identification of transient RNA G-quadruplexes in human cells","volume":"9","author":"Yang","year":"2018","journal-title":"Nat Commun"},{"key":"2026012711191530400_B35","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1093\/nar\/gkab187","article-title":"RNA G-quadruplexes (rG4s): genomics and biological functions","volume":"49","author":"Lyu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026012711191530400_B36","doi-asserted-by":"crossref","first-page":"20210214","DOI":"10.1002\/EXP.20210214","article-title":"Methodological advances of bioanalysis and biochemical targeting of intracellular G-quadruplexes","volume":"2","author":"Teng","year":"2022","journal-title":"Exploration"},{"key":"2026012711191530400_B37","doi-asserted-by":"publisher","first-page":"e1004012","DOI":"10.1371\/journal.ppat.1004012","article-title":"DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation","volume":"10","author":"Yoo","year":"2014","journal-title":"PLoS Pathog"},{"key":"2026012711191530400_B38","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.yexcr.2008.01.006","article-title":"Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU","volume":"314","author":"Iwamoto","year":"2008","journal-title":"Exp Cell Res"},{"key":"2026012711191530400_B39","doi-asserted-by":"publisher","first-page":"35186","DOI":"10.1074\/jbc.M804857200","article-title":"Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain","volume":"283","author":"Chalupn\u00edkov\u00e1","year":"2008","journal-title":"J Biol Chem"},{"key":"2026012711191530400_B40","doi-asserted-by":"publisher","first-page":"9369","DOI":"10.1093\/nar\/gkad613","article-title":"BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures","volume":"51","author":"Danino","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026012711191530400_B41","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.tibtech.2017.06.012","article-title":"G-quadruplexes: prediction, characterization, and biological application","volume":"35","author":"Kwok","year":"2017","journal-title":"Trends Biotechnol"},{"key":"2026012711191530400_B42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41580-023-00628-5","article-title":"Cellular functions of eukaryotic RNA helicases and their links to human diseases","volume":"24","author":"Bohnsack","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012711191530400_B43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012711191530400_B44","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cell.2017.10.033","article-title":"A method for the acute and rapid degradation of endogenous proteins","volume":"171","author":"Clift","year":"2017","journal-title":"Cell"},{"key":"2026012711191530400_B45","doi-asserted-by":"publisher","first-page":"12626","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4\u2013NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat Commun"},{"key":"2026012711191530400_B46","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1111\/gtc.13061","article-title":"DHX36 maintains genomic integrity by unwinding G-quadruplexes","volume":"28","author":"Mizumoto","year":"2023","journal-title":"Genes Cells"},{"key":"2026012711191530400_B47","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.molcel.2016.08.032","article-title":"Resetting epigenetic memory by reprogramming of histone modifications in mammals","volume":"63","author":"Zheng","year":"2016","journal-title":"Mol Cell"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/3\/gkag040\/66590431\/gkag040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/3\/gkag040\/66590431\/gkag040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:19:26Z","timestamp":1769530766000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag040\/8442280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,22]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag040","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2,10]]},"published":{"date-parts":[[2026,1,22]]},"article-number":"gkag040"}}