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However, relevant data remain dispersed across public repositories and the literature, limiting systematic integration, analysis, and reuse. We developed the Human Reproduction and Development Database (HRD; http:\/\/www.inbirg.com\/hrd\/), an integrated multi-omics resource that organizes publicly available data relevant to multiple reproductive, pregnancy, and developmental contexts. HRD version 1.0 contains 814 omics records, including 432 bulk transcriptomic, 144 single-cell or single-nucleus transcriptomic, 156 epigenomic, 52 metabolomic, and 30 proteomic records, together with 702 clinical trial records, 293 exposure-outcome associations, and 779 lead SNPs with curated phenotype associations. By harmonising key metadata and applying data-type-specific analysis workflows, HRD brings omics data, genetic associations, exposure-outcome evidence, and clinical trial data into a common framework for exploring data from multiple stages of reproduction and development. The website supports keyword search, combined filtering, category-based browsing, statistical summaries and data downloads, and provides interactive visualizations of differential analyses, functional enrichment, cell clustering, chromatin accessibility, peak annotation, regulatory networks, and cross-phenotype association plots. HRD supports the retrieval, comparison, and reuse of reproductive and developmental data and analysis results.<\/jats:p>","DOI":"10.1093\/nar\/gkag1006","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:33:15Z","timestamp":1792398795000},"source":"Crossref","is-referenced-by-count":0,"title":["HRD: an integrated multi-omics resource for human reproduction and development"],"prefix":"10.1093","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]},{"name":"Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University , Chongqing 400016 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