{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:37:39Z","timestamp":1792654659299,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62471240"],"award-info":[{"award-number":["62471240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62231013"],"award-info":[{"award-number":["62231013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genome-wide association studies (GWAS) identify loci associated with human diseases and disease-related traits, but the regulators and cellular contexts linked to these signals remain difficult to resolve. We present scTraitReg, a database of trait-relevant transcription factor (TF) eRegulons\u2014TFs with their target genes and linked cis-regulatory regions\u2014at single-cell resolution. scTraitReg integrates 655 sets of curated GWAS summary statistics covering 122 Medical Subject Headings (MeSH) disease terms with 111 human single-cell multi-omic datasets profiling RNA and chromatin accessibility in the same cells. The resource spans 34 tissues, 252 cell types, 2 081 538 cells, and 2208 curated GWAS\u2014single-cell analysis pairs. Across these analyses, it contains 2 840 939 TF\u2013cell-type records for 886 regulators; 67 666 records met all three criteria\u2014cell-type specificity, genetic relevance, and the trait-associated regulon score\u2014and were included as candidate trait-relevant eRegulon records. Each record links to the TF\u2014target regulatory network with its cis-regulatory regions, cell-type-resolved evidence, per-cell regulon module scores, and target-gene enrichment, all available as downloadable tables. Users can search by disease, tissue, cell type, or regulator and examine these associations through interactive visualizations. scTraitReg thus provides a searchable and reusable resource linking genetic associations to cell-type-specific regulatory programs, and is freely available at https:\/\/www.sctraitreg.bio\/.<\/jats:p>","DOI":"10.1093\/nar\/gkag1017","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:38:51Z","timestamp":1792651131000},"source":"Crossref","is-referenced-by-count":0,"title":["scTraitReg: a single-cell multi-omic database of trait-relevant transcription factor eRegulons"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-3226","authenticated-orcid":false,"given":"Haoran","family":"Chen","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory for Biomedical Electromagnetic Precision Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University , Nanjing, Jiangsu 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Jiangsu 211166 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Medical Research Center, Children\u2019s Hospital of Nanjing Medical University , Nanjing, Jiangsu 210008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1251-5959","authenticated-orcid":false,"given":"Xiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, The Second Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu 210011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-808X","authenticated-orcid":false,"given":"Chen","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Biomedical Electromagnetic Precision Theranostics, School of Biomedical Engineering and Informatics, Nanjing 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