{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:50:25Z","timestamp":1773215425592,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1803504"],"award-info":[{"award-number":["2024YFA1803504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070111"],"award-info":[{"award-number":["82070111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92368108"],"award-info":[{"award-number":["92368108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070111"],"award-info":[{"award-number":["82070111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Erythropoiesis requires precise coordination of transcriptional and co-\/post-transcriptional programs, yet the role of alternative polyadenylation (APA) in this process remains poorly understood. Here, we profiled the genome-wide dynamic APA landscape during erythropoiesis using single-cell RNA sequencing (scRNA-seq). Through clustering and functional enrichment analysis, seven distinct APA dynamic patterns were identified, with genes showing stage-specific APA changes enriched in erythroid lineage differentiation, heme synthesis, and iron metabolism. Combining motif analysis near polyadenylation sites (PASs) and APA regulators expression profiling, we observed that cleavage and polyadenylation specificity factor 6 (CPSF6), a critical APA regulator, exhibited significant variation. Functional assays demonstrated that CPSF6 facilitates erythropoiesis, as its depletion impaired heme synthesis and intracellular iron deficiency. Mechanistically, CPSF6 depletion shortened the 3\u2032UTR length of iron metabolism regulators (FAM210B, IREB2, TFRC), which was accompanied by reduced expression of these genes. Clinically, CPSF6 and these APA-regulated iron metabolism-related genes were aberrantly upregulated in polycythemia vera (PV) patients, correlating with erythroid hyperproliferation. Collectively, our findings support a CPSF6-APA-iron homeostasis axis as an important co-\/post- transcriptional regulatory mechanism in erythropoiesis, and implicate its dysregulation in the pathogenesis of PV, offering novel molecular targets for therapeutic intervention in myeloproliferative neoplasms.<\/jats:p>","DOI":"10.1093\/nar\/gkag218","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:24:34Z","timestamp":1772454274000},"source":"Crossref","is-referenced-by-count":0,"title":["Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis"],"prefix":"10.1093","volume":"54","author":[{"given":"Shan","family":"Yu","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Chongqing Medical University , Chongqing 400016 ,","place":["China"]},{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of 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,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-612X","authenticated-orcid":false,"given":"Ping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College , Be\u0133ing 100005 ,","place":["China"]},{"name":"The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences , Be\u0133ing 100005 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