{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:12:36Z","timestamp":1790284356139,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["#2153787"],"award-info":[{"award-number":["#2153787"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 GM150642"],"award-info":[{"award-number":["R01 GM150642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35GM156171"],"award-info":[{"award-number":["R35GM156171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Colorado Cancer Center Support","award":["P30 CA046934"],"award-info":[{"award-number":["P30 CA046934"]}]},{"name":"Biomedical Research Support","award":["S10 OD025020-01"],"award-info":[{"award-number":["S10 OD025020-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While it is well established that the Z\u03b1 domains of ADAR1 and ZBP1 proteins bind Z-form-prone nucleic acids (Z-NAs), it has also been shown that the Z\u03b1 domain of ADAR1 binds DNA G-quadruplexes (GQs). However, no binding partner of the structurally homologous Z\u03b2 domain of ADAR1 has been identified to date. Based on AlphaFold and molecular dynamics simulations, it has recently been suggested that Z\u03b2 of ADAR1 targets its substrate by recognizing GQs. Here, we provide the first experimental evidence for Z\u03b2 binding to select GQ RNA and DNA in vitro, with structural specificity and nanomolar affinity. We also demonstrate that the Z\u03b1 domains of ZBP1 and ADAR1 bind to both DNA and RNA GQs with similar affinity. These findings extend the range of potential functional roles for these proteins and open new hypotheses for testing in cells.<\/jats:p>","DOI":"10.1093\/nar\/gkag419","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:32:22Z","timestamp":1776771142000},"source":"Crossref","is-referenced-by-count":2,"title":["Z\u03b1 and Z\u03b2 domains of ADAR1 and ZBP1 bind G-quadruplexes with nanomolar affinities, establishing Z\u03b2 as a G-quadruplex-specific domain"],"prefix":"10.1093","volume":"54","author":[{"given":"Charles W","family":"Kroft","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Krall","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Warchol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robb","family":"Welty","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0093-1572","authenticated-orcid":false,"given":"Alan","family":"Herbert","sequence":"additional","affiliation":[{"name":"Discovery, InsideOutBio , 42 8th Street, Unit 3412, Charlestown, MA 02129 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-5583","authenticated-orcid":false,"given":"Morkos A","family":"Henen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-3137","authenticated-orcid":false,"given":"Beat","family":"V\u00f6geli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United 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