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To achieve this, we introduced bipyridine ligands into short oligonucleotide strands derived from telomeric regions of humans and Tetrahymena as well as into an oncogenic promoter region capable of forming such G-quadruplexes. This modification makes it possible to dynamically access different G-quadruplex topologies through the formation of chelate complexes within the quadruplex loop regions using metals such as Cu2+, Ni2+, Zn2+, Co2+, and Cd2+. The metal-coordinated systems show enhanced stability towards thermal denaturation as well as a solvation-related response in the presence of molecular crowding reagents. Interestingly, these G-quadruplexes modified with bipyridine-metal complexes stay folded in cellulo and therefore show potential for creating new oligonucleotide-based diagnostic agents and therapeutics. Metal-stabilized G-quadruplexes could therefore be suitable as probes to explore protein-G4 interactions, as inducers for G4-dependent cellular processes, or decoys to sequester transcription factors.<\/jats:p>","DOI":"10.1093\/nar\/gkag738","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:36:23Z","timestamp":1784633783000},"source":"Crossref","is-referenced-by-count":0,"title":["Metal-triggered topology switching in bipyridine-modified DNA G-quadruplexes"],"prefix":"10.1093","volume":"54","author":[{"given":"Armin","family":"Durmisevic","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn Str. 6, 44227 Dortmund ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Openy","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn Str. 6, 44227 Dortmund 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