{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:46:34Z","timestamp":1792183594196,"version":"4.4.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["945339"],"award-info":[{"award-number":["945339"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IMPULZ","award":["IM-2022-62"],"award-info":[{"award-number":["IM-2022-62"]}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-24-0598"],"award-info":[{"award-number":["APVV-24-0598"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CX-5461 (pidnarulex) is the most clinically advanced small-molecule ligand associated with G-quadruplex (G4) targeting and shows activity in DNA repair\u2013deficient tumors, yet its clinical use is associated with dose-limiting phototoxicity. Here, we repurpose this intrinsic photoreactivity to investigate\u00a0CX-5461 as a G4-associated, light-activated antitumor scaffold. In solution, CX-5461 produces both Type I and Type II reactive oxygen species (ROS), whereas complexation with G4 DNA markedly decreases detectable singlet oxygen (1O2) formation and favors radical-associated Type I oxidation. This G4-modulated photochemical shift drives oxidative remodeling and destabilization of G4-containing DNA. In cancer cells, photoactivation enhances cytotoxicity by up to two orders of magnitude relative to the dark state and is accompanied by elevated intracellular ROS, increased 8-oxoG formation, \u03b3-H2AX accumulation, and changes in BG4-detected nuclear G4 structures. In vivo, light-activated CX-5461 suppresses tumor growth and extends survival in immunocompetent syngeneic models, eliciting hallmarks consistent with immunogenic genome stress. Collectively, these findings reposition CX-5461 as a clinically relevant scaffold for G4-associated photogenomic cancer therapy, while supporting a model in which broader oxidative DNA damage may also contribute to the biological response.<\/jats:p>","DOI":"10.1093\/nar\/gkag777","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:21:29Z","timestamp":1785151289000},"source":"Crossref","is-referenced-by-count":2,"title":["G-quadruplex DNA reprograms the photochemistry of CX-5461 toward radical-driven anticancer activity"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3258-5123","authenticated-orcid":false,"given":"Jakub","family":"Trojnar","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Institute of Advanced Materials, Wroc\u0142aw University of Science and Technology , Wyb. Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V","family":"Cottini","sequence":"additional","affiliation":[{"name":"Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences , Dubravska cesta 21, 845 51 Bratislava ,","place":["Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6749-0903","authenticated-orcid":false,"given":"Marta","family":"Dudek","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Institute of Advanced Materials, Wroc\u0142aw University of Science and Technology , Wyb. Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-2416","authenticated-orcid":false,"given":"Cyrille","family":"Monnereau","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, Laboratoire de Chimie , UMR 5182, 46 all\u00e9e d\u2019Italie, F-69342 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lhoussain","family":"Khrouz","sequence":"additional","affiliation":[{"name":"ENS de Lyon, CNRS, Laboratoire de Chimie , UMR 5182, 46 all\u00e9e d\u2019Italie, F-69342 Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Wei","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Clinical Department, Senhwa Biosciences, Inc. , 10F, No. 225, Sec. 3, Peihsin Rd., Hsintien Dist., 23143 New Taipei City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Department, Senhwa Biosciences, Inc. , 10F, No. 225, Sec. 3, Peihsin Rd., Hsintien Dist., 23143 New Taipei City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Yen","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Department, Senhwa Biosciences, Inc. , 10F, No. 225, Sec. 3, Peihsin Rd., Hsintien Dist., 23143 New Taipei City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-7663","authenticated-orcid":false,"given":"Jan","family":"Jamroskovic","sequence":"additional","affiliation":[{"name":"Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences , Dubravska cesta 21, 845 51 Bratislava ,","place":["Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-4494","authenticated-orcid":false,"given":"Marco","family":"Deiana","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Institute of Advanced Materials, Wroc\u0142aw University of Science and Technology , Wyb. Wyspia\u0144skiego 27, 50-370 Wroc\u0142aw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026081105000769200_B1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026081105000769200_B2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12943-021-01328-4","article-title":"G-quadruplexes: a promising target for cancer therapy","volume":"20","author":"Kosiol","year":"2021","journal-title":"Mol Cancer"},{"key":"2026081105000769200_B3","doi-asserted-by":"publisher","first-page":"9640","DOI":"10.1021\/ja404868t","article-title":"G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells","volume":"135","author":"McLuckie","year":"2013","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B4","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1021\/jacs.9b11232","article-title":"Quinazoline ligands induce cancer cell death through selective STAT3 inhibition and G-quadruplex stabilization","volume":"142","author":"Jamroskovic","year":"2020","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B5","doi-asserted-by":"publisher","first-page":"5987","DOI":"10.1021\/acs.jmedchem.5b01835","article-title":"Quadruplex nucleic acids as novel therapeutic targets","volume":"59","author":"Neidle","year":"2016","journal-title":"J Med Chem"},{"key":"2026081105000769200_B6","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.molcel.2015.12.004","article-title":"Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds","volume":"61","author":"Zimmer","year":"2016","journal-title":"Mol Cell"},{"key":"2026081105000769200_B7","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1021\/jacs.9b11050","article-title":"Interplay of guanine oxidation and G-quadruplex folding in gene promoters","volume":"142","author":"Fleming","year":"2020","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B8","doi-asserted-by":"publisher","first-page":"zcab038","DOI":"10.1093\/narcan\/zcab038","article-title":"Oxidative stress-mediated epigenetic regulation by G-quadruplexes","volume":"3","author":"Fleming","year":"2021","journal-title":"NAR Cancer"},{"key":"2026081105000769200_B9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41419-023-05562-0","article-title":"Crosstalk between G-quadruplex and ROS","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026081105000769200_B10","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1039\/D5NH00237K","article-title":"G-quadruplex-driven molecular disassembly and type I-to-type II photophysical conversion of a heavy-atom-free photosensitizer for site-specific oxidative damage","volume":"10","author":"Saczuk","year":"2025","journal-title":"Nanoscale Horiz"},{"key":"2026081105000769200_B11","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1021\/acsptsci.5c00061","article-title":"Photodynamic therapy using a heavy-atom-free G-quadruplex-targeted photosensitizer to efficiently regress rhabdomyosarcoma tumors in vivo","volume":"8","author":"Rodriguez-Marquez","year":"2025","journal-title":"ACS Pharmacol Transl Sci"},{"key":"2026081105000769200_B12","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1093\/nar\/gkad365","article-title":"A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression","volume":"51","author":"Deiana","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B13","doi-asserted-by":"publisher","first-page":"e202501545","DOI":"10.1002\/chem.202501545","article-title":"Light-activated molecules targeting G-quadruplex nucleic acids","volume":"31","author":"Dudek","year":"2025","journal-title":"Chemistry"},{"key":"2026081105000769200_B14","doi-asserted-by":"publisher","first-page":"e202413000","DOI":"10.1002\/anie.202413000","article-title":"A rationally designed azobenzene photoswitch for DNA G-quadruplex regulation in live cells","volume":"64","author":"Dudek","year":"2025","journal-title":"Angew Chem Int Ed"},{"key":"2026081105000769200_B15","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/s41557-025-01792-1","article-title":"Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch","volume":"17","author":"Zhang","year":"2025","journal-title":"Nat Chem"},{"key":"2026081105000769200_B16","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1186\/s12967-025-06473-8","article-title":"The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment","volume":"23","author":"Li","year":"2025","journal-title":"J Transl Med"},{"key":"2026081105000769200_B17","doi-asserted-by":"publisher","first-page":"14432","DOI":"10.1038\/ncomms14432","article-title":"CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1\/2 deficient tumours","volume":"8","author":"Xu","year":"2017","journal-title":"Nat Commun"},{"key":"2026081105000769200_B18","doi-asserted-by":"publisher","first-page":"gkaf939","DOI":"10.1093\/nar\/gkaf939","article-title":"ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation","volume":"53","author":"Pang","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B19","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1021\/ml300110s","article-title":"Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeutics","volume":"3","author":"Haddach","year":"2012","journal-title":"ACS Med Chem Lett"},{"key":"2026081105000769200_B20","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1073\/pnas.1921649117","article-title":"The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning","volume":"117","author":"Bruno","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026081105000769200_B21","doi-asserted-by":"publisher","first-page":"zcaa032","DOI":"10.1093\/narcan\/zcaa032","article-title":"The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability","volume":"2","author":"Mars","year":"2020","journal-title":"NAR Cancer"},{"key":"2026081105000769200_B22","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1038\/s41467-022-31199-2","article-title":"Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies","volume":"13","author":"Hilton","year":"2022","journal-title":"Nat Commun"},{"key":"2026081105000769200_B23","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1038\/s41467-020-16393-4","article-title":"CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer","volume":"11","author":"Sanij","year":"2020","journal-title":"Nat Commun"},{"key":"2026081105000769200_B24","doi-asserted-by":"publisher","first-page":"129384","DOI":"10.1016\/j.bmcl.2023.129384","article-title":"A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461","volume":"91","author":"Jin","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"key":"2026081105000769200_B25","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1529\/biophysj.106.082388","article-title":"Singlet oxygen generation by UVA light exposure of endogenous photosensitizers","volume":"91","author":"Baier","year":"2006","journal-title":"Biophys J"},{"key":"2026081105000769200_B26","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1093\/nar\/gkab1073","article-title":"Genome-wide mapping of G-quadruplex structures with CUT&Tag","volume":"50","author":"Lyu","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B27","doi-asserted-by":"publisher","first-page":"5203","DOI":"10.1021\/acs.jcim.0c00632","article-title":"Molecular dynamics study on the binding of an anticancer DNA G-quadruplex stabilizer, CX-5461, to human telomeric, c-KIT1, and c-Myc G-quadruplexes and a DNA duplex","volume":"60","author":"Sullivan","year":"2020","journal-title":"J Chem Inf Model"},{"key":"2026081105000769200_B28","doi-asserted-by":"publisher","first-page":"180","DOI":"10.52601\/bpr.2024.240018","article-title":"Unfolding rates of 1:1 and 2:1 complex of CX-5461 and c-MYC promoter G-quadruplexes revealed by single-molecule force spectroscopy","volume":"10","author":"Peng","year":"2024","journal-title":"Biophys Rep"},{"key":"2026081105000769200_B29","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1039\/b926014p","article-title":"Singlet oxygen: there is indeed something new under the sun","volume":"39","author":"Ogilby","year":"2010","journal-title":"Chem Soc Rev"},{"key":"2026081105000769200_B30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.freeradbiomed.2014.08.020","article-title":"Scope and limitations of the TEMPO\/EPR method for singlet oxygen detection: the misleading role of electron transfer","volume":"77","author":"Nardi","year":"2014","journal-title":"Free Radical Biol Med"},{"key":"2026081105000769200_B31","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.1039\/C8AY01339J","article-title":"Methods for the detection of reactive oxygen species","volume":"10","author":"Zhang","year":"2018","journal-title":"Anal Methods"},{"key":"2026081105000769200_B32","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1074\/jbc.M209264200","article-title":"Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species","volume":"278","author":"Setsukinai","year":"2003","journal-title":"J Biol Chem"},{"key":"2026081105000769200_B33","doi-asserted-by":"publisher","first-page":"e2516113122","DOI":"10.1073\/pnas.2516113122","article-title":"Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered","volume":"122","author":"Korshunov","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026081105000769200_B34","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1021\/acs.jpclett.5c00136","article-title":"Organelle-specific thiochromenocarbazole imide derivative as a heavy-atom-free type I photosensitizer for biomolecule-triggered image-guided photodynamic therapy","volume":"16","author":"Saczuk","year":"2025","journal-title":"J Phys Chem Lett"},{"key":"2026081105000769200_B35","doi-asserted-by":"publisher","first-page":"e202300162","DOI":"10.1002\/anie.202300162","article-title":"Type I photosensitizer targeting G-quadruplex RNA elicits augmented immunity for cancer ablation","volume":"62","author":"Chen","year":"2023","journal-title":"Angew Chem Int Ed"},{"key":"2026081105000769200_B36","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1038\/s41467-018-04771-y","article-title":"An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex","volume":"9","author":"Kawauchi","year":"2018","journal-title":"Nat Commun"},{"key":"2026081105000769200_B37","doi-asserted-by":"crossref","first-page":"2301570","DOI":"10.1002\/smtd.202301570","article-title":"Exploiting G-quadruplex-DNA damage as a tool to quantify singlet oxygen production","volume":"8","author":"De\u00a0Paepe","year":"2024","journal-title":"Small Methods"},{"key":"2026081105000769200_B38","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1021\/jacs.8b12748","article-title":"Impact of oxidative lesions on the human telomeric G-quadruplex","volume":"141","author":"Bielskut\u0117","year":"2019","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1742-4658.2011.08396.x","article-title":"8-Oxoguanine in a quadruplex of the human telomere DNA sequence","volume":"279","author":"Vorl\u00edckov\u00e1","year":"2012","journal-title":"FEBS J"},{"key":"2026081105000769200_B40","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1093\/nar\/gkv252","article-title":"The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures","volume":"43","author":"Zhou","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B41","doi-asserted-by":"publisher","first-page":"6361","DOI":"10.1021\/jacs.2c00435","article-title":"Oxidative damage induces a vacancy G-quadruplex that binds guanine metabolites: solution structure of a cGMP fill-in vacancy G-quadruplex in the oxidized BLM gene promoter","volume":"144","author":"Wang","year":"2022","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B42","first-page":"10506","article-title":"Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G\u00b7G\u00b7X\u00b7O tetrad","volume":"43","author":"Cheong","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B43","doi-asserted-by":"publisher","first-page":"e26126","DOI":"10.1002\/anie.202526126","article-title":"Oxidative damage fine-tunes G-quadruplex structures in human gene promoters","volume":"65","author":"Wang","year":"2026","journal-title":"Angew Chem Int Ed"},{"key":"2026081105000769200_B44","doi-asserted-by":"publisher","first-page":"12331","DOI":"10.1021\/ja101252n","article-title":"Coexistence of two distinct G-quadruplex conformations in the hTERT promoter","volume":"132","author":"Lim","year":"2010","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B45","first-page":"11364","article-title":"DNA damage accelerates G-quadruplex folding in a duplex-G-quadruplex-duplex context","volume":"146","author":"Fleming","year":"2024","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B46","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1093\/nar\/gkad014","article-title":"Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 \u00c5 resolution with cryo-EM","volume":"51","author":"Monsen","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B47","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1093\/nar\/gkad1209","article-title":"BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions","volume":"52","author":"Johnson\u00a0Samuel","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026081105000769200_B48","doi-asserted-by":"publisher","first-page":"e2419175121","DOI":"10.1073\/pnas.2419175121","article-title":"CO2 protects cells from iron-Fenton oxidative DNA damage in Escherichia coli and humans","volume":"121","author":"Fleming","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026081105000769200_B49","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1039\/D1AN00456E","article-title":"Intracellular detection of singlet oxygen using fluorescent nanosensors","volume":"146","author":"Nath","year":"2021","journal-title":"Analyst"},{"key":"2026081105000769200_B50","doi-asserted-by":"publisher","first-page":"13685","DOI":"10.1038\/s41598-018-31638-5","article-title":"Singlet oxygen imaging using fluorescent probe Singlet Oxygen Sensor Green in photosynthetic organisms","volume":"8","author":"Prasad","year":"2018","journal-title":"Sci Rep"},{"key":"2026081105000769200_B51","doi-asserted-by":"publisher","first-page":"7025","DOI":"10.1039\/D1CS01079D","article-title":"New guidelines and definitions for type I photodynamic therapy","volume":"54","author":"Li","year":"2025","journal-title":"Chem Soc Rev"},{"key":"2026081105000769200_B52","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nchem.1548","article-title":"Quantitative visualization of DNA G-quadruplex structures in human cells","volume":"5","author":"Biffi","year":"2013","journal-title":"Nature Chem"},{"key":"2026081105000769200_B53","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1021\/acscentsci.5b00202","article-title":"A role for the fifth G-track in G-quadruplex forming oncogene promoter sequences during oxidative stress: do these \u201cspare tires\u201d have an evolved function?","volume":"1","author":"Fleming","year":"2015","journal-title":"ACS Cent Sci"},{"key":"2026081105000769200_B54","doi-asserted-by":"publisher","first-page":"100856","DOI":"10.1016\/j.neo.2022.100856","article-title":"A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer","volume":"35","author":"Chung","year":"2023","journal-title":"Neoplasia"},{"key":"2026081105000769200_B55","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1021\/jacsau.2c00591","article-title":"Immuno-photodynamic therapy (IPDT): organic photosensitizers and their application in cancer ablation","volume":"3","author":"Lu","year":"2023","journal-title":"JACS Au"},{"key":"2026081105000769200_B56","doi-asserted-by":"publisher","first-page":"189","DOI":"10.5114\/ceji.2023.132053","article-title":"Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer","volume":"48","author":"Wang","year":"2023","journal-title":"Cent Eur J Immunol"},{"key":"2026081105000769200_B57","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3389\/fonc.2019.00811","article-title":"Low photosensitizer dose and early radiotherapy enhance antitumor immune response of photodynamic therapy-based dendritic cell vaccination","volume":"9","author":"Doix","year":"2019","journal-title":"Front Oncol"},{"key":"2026081105000769200_B58","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.3390\/cancers13205056","article-title":"CX-5461 treatment leads to cytosolic DNA-mediated STING activation in ovarian cancer","volume":"13","author":"Cornelison","year":"2021","journal-title":"Cancers"},{"key":"2026081105000769200_B59","doi-asserted-by":"publisher","first-page":"e09121","DOI":"10.1002\/anie.202509121","article-title":"Seamlessly overcoming biological barriers with a small photosensitizer to treat metastatic tumors with photodynamic therapy","volume":"65","author":"Penetra","year":"2026","journal-title":"Angew Chem Int Ed"},{"key":"2026081105000769200_B60","doi-asserted-by":"publisher","first-page":"28973","DOI":"10.1021\/jacs.4c09831","article-title":"A type I photosensitizer-polymersome boosts reactive oxygen species generation by forcing H-aggregation for amplifying STING immunotherapy","volume":"146","author":"Wang","year":"2024","journal-title":"J Am Chem Soc"},{"key":"2026081105000769200_B61","doi-asserted-by":"publisher","first-page":"12502","DOI":"10.1021\/jacs.6b06663","article-title":"Chlorin-based nanoscale metal\u2013organic framework systemically rejects colorectal cancers via synergistic photodynamic therapy and checkpoint blockade immunotherapy","volume":"138","author":"Lu","year":"2016","journal-title":"J Am Chem Soc"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/15\/gkag777\/70608163\/gkag777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/15\/gkag777\/70608163\/gkag777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:01:44Z","timestamp":1786438904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag777\/8758773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":61,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8,10]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag777","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,27]]},"published":{"date-parts":[[2026,8,10]]},"article-number":"gkag777"}}