{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:17:40Z","timestamp":1787818660777,"version":"build-2784847793"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA139429"],"award-info":[{"award-number":["R01 CA139429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 ES007061"],"award-info":[{"award-number":["RO1 ES007061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1 CA275717"],"award-info":[{"award-number":["PO1 CA275717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R50 CA265315"],"award-info":[{"award-number":["R50 CA265315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA279363"],"award-info":[{"award-number":["T32 CA279363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA148724"],"award-info":[{"award-number":["T32 CA148724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220269"],"award-info":[{"award-number":["RP220269"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert A. Welch Distinguished Chair in Chemistry","award":["AQ-0012"],"award-info":[{"award-number":["AQ-0012"]}]},{"DOI":"10.13039\/100008635","name":"University of Texas Health Science Center at San Antonio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Given their defect in homologous recombination, BRCA1-deficient cancers use polymerase theta (POLQ) microhomology-mediated end joining (MMEJ) for repair of stressed replication forks. We found that BRCA1-deficient cells repress microRNA (miR) 4485-3p, and reconstituting expression of this miR resulted in the death of BRCA1-deficient cells. In our interrogation of the mechanism of this synthetic lethality, we discovered that miR-4485-3p suppresses expression of RPRD1B protein. Depletion of RPRD1B led to selective BRCA1-deficient cell death, decreased MMEJ, and decreased replication fork repair after replication stress. RPRD1B promotes the recruitment of the MMEJ components 53BP1, PARP1, and POLQ to the stressed replication fork. However, RPRD1B does not have a canonical DNA-binding domain, and our search for the mechanism of its recruitment to stressed replication forks discovered that this is mediated by RECQL5 and ubiquitinated (Ub) PCNA. Thus, our results unveil an essential signaling cascade at the stressed replication fork in BRCA1-deficient cancer cells, in which Ub PCNA recruits RECQL5, which recruits RPRD1B to mediate the assembly of the MMEJ repair apparatus. These data suggest that this repair scaffold may be targeted in the development of a novel synthetic therapy of BRCA1-deficient cancers.<\/jats:p>","DOI":"10.1093\/nar\/gkag831","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:40:41Z","timestamp":1786448441000},"source":"Crossref","is-referenced-by-count":0,"title":["PCNA\u2013RECQL5\u2013RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells"],"prefix":"10.1093","volume":"54","author":[{"given":"Manh Tien","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna S","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Arris","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhat","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimi","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montasser","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doraid","family":"Sadadeen","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daohong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-3566","authenticated-orcid":false,"given":"Shahrez","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-8795","authenticated-orcid":false,"given":"Youngho","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Salunkhe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, the Center for Innovative Drug Discovery, and the Greehey Children\u2019s Cancer Research Institute, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-6276","authenticated-orcid":false,"given":"Robert","family":"Hromas","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Mays Cancer Center, the University of Texas Health Science Center San Antonio , San Antonio, TX 78229 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026082703245873000_B1","doi-asserted-by":"publisher","first-page":"14276","DOI":"10.3390\/ijms241814276","article-title":"BRCA1 the versatile defender: molecular to environmental perspectives","volume":"24","author":"Zhong","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026082703245873000_B2","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1056\/nejm199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"N Engl J Med"},{"key":"2026082703245873000_B3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41586-024-07909-9","article-title":"Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection","volume":"634","author":"Ceppi","year":"2024","journal-title":"Nature"},{"key":"2026082703245873000_B4","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41586-024-07910-2","article-title":"Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination","volume":"634","author":"Salunkhe","year":"2024","journal-title":"Nature"},{"key":"2026082703245873000_B5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nrm2831","article-title":"BRCA1 and its toolbox for the maintenance of genome integrity","volume":"11","author":"Huen","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026082703245873000_B6","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1074\/jbc.RA118.005188","article-title":"DNA polymerase \u03b8 (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse","volume":"294","author":"Wang","year":"2019","journal-title":"J Biol Chem"},{"key":"2026082703245873000_B7","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1016\/j.molcel.2022.08.017","article-title":"Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells","volume":"82","author":"Deshpande","year":"2022","journal-title":"Mol Cell"},{"key":"2026082703245873000_B8","doi-asserted-by":"publisher","first-page":"e1697","DOI":"10.1038\/cddis.2015.58","article-title":"Homology and enzymatic requirements of microhomology-dependent alternative end joining","volume":"6","author":"Sharma","year":"2015","journal-title":"Cell Death Dis"},{"key":"2026082703245873000_B9","doi-asserted-by":"publisher","first-page":"6170","DOI":"10.1093\/nar\/gkl840","article-title":"PARP-1 and Ku compete for repair of DNA double-strand breaks by distinct NHEJ pathways","volume":"34","author":"Wang","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B10","doi-asserted-by":"publisher","first-page":"8476","DOI":"10.1073\/pnas.1921791117","article-title":"Mechanistic basis for microhomology identification and genome scarring by polymerase theta","volume":"117","author":"Carvajal-Garcia","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082703245873000_B11","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1073\/pnas.1521597113","article-title":"Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining","volume":"113","author":"Lu","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082703245873000_B12","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3390\/cancers13061392","article-title":"Alternative non-homologous end-joining: error-prone DNA repair as cancer\u2019s Achilles\u2019 heel","volume":"13","author":"Caracciolo","year":"2021","journal-title":"Cancer"},{"key":"2026082703245873000_B13","doi-asserted-by":"publisher","first-page":"e1006714","DOI":"10.1371\/journal.pgen.1006714","article-title":"Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions","volume":"13","author":"Sinha","year":"2017","journal-title":"PLoS Genet"},{"key":"2026082703245873000_B14","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1182\/blood-2012-10-460527","article-title":"PARP1 is required for chromosomal translocations","volume":"121","author":"Wray","year":"2013","journal-title":"Blood"},{"key":"2026082703245873000_B15","doi-asserted-by":"publisher","first-page":"7720","DOI":"10.1073\/pnas.1213431110","article-title":"Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells","volume":"110","author":"Truong","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082703245873000_B16","doi-asserted-by":"publisher","first-page":"gkaf710","DOI":"10.1093\/nar\/gkaf710","article-title":"FEN1 is critical for rapid single-strand break repair in G1 phase","volume":"53","author":"Burdova","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B17","doi-asserted-by":"publisher","first-page":"20410","DOI":"10.1021\/acs.jmedchem.5c01526","article-title":"Fragment-based discovery and structure-led optimization of MSC778, the first potent, selective, and orally bioavailable FEN1 inhibitor","volume":"68","author":"Mann","year":"2025","journal-title":"J Med Chem"},{"key":"2026082703245873000_B18","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.molcel.2018.12.008","article-title":"Genetic screens reveal FEN1 and APEX2 as BRCA2 synthetic lethal targets","volume":"73","author":"Mengwasser","year":"2019","journal-title":"Mol Cell"},{"key":"2026082703245873000_B19","doi-asserted-by":"publisher","first-page":"105626","DOI":"10.1016\/j.isci.2022.105626","article-title":"BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1","volume":"25","author":"Hromas","year":"2022","journal-title":"iScience"},{"key":"2026082703245873000_B20","doi-asserted-by":"publisher","first-page":"17438","DOI":"10.1073\/pnas.1903150116","article-title":"MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers","volume":"116","author":"Srinivasan","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082703245873000_B21","doi-asserted-by":"publisher","first-page":"12224","DOI":"10.1093\/nar\/gkad952","article-title":"TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells","volume":"51","author":"Jaiswal","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4161\/trns.2.5.17803","article-title":"Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B","volume":"2","author":"Ni","year":"2011","journal-title":"Transcription"},{"key":"2026082703245873000_B23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s13402-020-00569-7","article-title":"CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma","volume":"44","author":"Yang","year":"2021","journal-title":"Cell Oncol"},{"key":"2026082703245873000_B24","doi-asserted-by":"publisher","first-page":"4996","DOI":"10.1093\/nar\/gku160","article-title":"Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair","volume":"42","author":"Morales","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B25","doi-asserted-by":"publisher","first-page":"e31288","DOI":"10.1371\/journal.pone.0031288","article-title":"Yeast transcription termination factor Rtt103 functions in DNA damage response","volume":"7","author":"Srividya","year":"2012","journal-title":"PLoS One"},{"key":"2026082703245873000_B26","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1093\/nar\/gkv1492","article-title":"The Kub5-Hera\/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair","volume":"44","author":"Patidar","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B27","doi-asserted-by":"publisher","first-page":"zcac044","DOI":"10.1093\/narcan\/zcac044","article-title":"EEPD1 promotes repair of oxidatively-stressed replication forks","volume":"5","author":"Jaiswal","year":"2023","journal-title":"NAR Cancer"},{"key":"2026082703245873000_B28","doi-asserted-by":"publisher","first-page":"e1005675","DOI":"10.1371\/journal.pgen.1005675","article-title":"EEPD1 rescues stressed replication forks and maintains genome stability by promoting end resection and homologous recombination repair","volume":"11","author":"Wu","year":"2015","journal-title":"PLoS Genet"},{"key":"2026082703245873000_B29","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1101\/gad.1609107","article-title":"RECQL5\/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments","volume":"21","author":"Hu","year":"2007","journal-title":"Genes Dev"},{"key":"2026082703245873000_B30","doi-asserted-by":"publisher","first-page":"9023","DOI":"10.1074\/jbc.M800150200","article-title":"Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair","volume":"283","author":"Beck","year":"2008","journal-title":"J Biol Chem"},{"key":"2026082703245873000_B31","doi-asserted-by":"publisher","first-page":"e1000110","DOI":"10.1371\/journal.pgen.1000110","article-title":"Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair","volume":"4","author":"Bennardo","year":"2008","journal-title":"PLoS Genet"},{"key":"2026082703245873000_B32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"2026082703245873000_B33","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/mutage\/geq052","article-title":"Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells","volume":"26","author":"Fenech","year":"2011","journal-title":"Mutagenesis"},{"key":"2026082703245873000_B34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1053\/j.seminoncol.2023.09.005","article-title":"PARP inhibitors: a review of the pharmacology, pharmacokinetics, and pharmacogenetics","volume":"51","author":"Zeng","year":"2024","journal-title":"Semin Oncol"},{"key":"2026082703245873000_B35","doi-asserted-by":"publisher","first-page":"e1004943","DOI":"10.1371\/journal.pgen.1004943","article-title":"DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining","volume":"11","author":"Howard","year":"2015","journal-title":"PLoS Genet"},{"key":"2026082703245873000_B36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13058-017-0912-8","article-title":"The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells","volume":"19","author":"Hromas","year":"2017","journal-title":"Breast Cancer Res"},{"key":"2026082703245873000_B37","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1080\/15384101.2016.1151585","article-title":"The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis","volume":"15","author":"Chun","year":"2016","journal-title":"Cell Cycle"},{"key":"2026082703245873000_B38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41586-023-06461-2","article-title":"Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers","volume":"621","author":"Setton","year":"2023","journal-title":"Nature"},{"key":"2026082703245873000_B39","doi-asserted-by":"publisher","first-page":"103731","DOI":"10.1016\/j.dnarep.2024.103731","article-title":"Mechanisms and regulation of replication fork reversal","volume":"141","author":"Adolph","year":"2024","journal-title":"DNA Repair"},{"key":"2026082703245873000_B40","doi-asserted-by":"publisher","first-page":"27674","DOI":"10.18632\/oncotarget.4876","article-title":"Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining","volume":"6","author":"Beckta","year":"2015","journal-title":"Oncotarget"},{"key":"2026082703245873000_B41","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/jmcb\/mjq056","article-title":"A Blm-Recql5 partnership in replication stress response","volume":"3","author":"Lu","year":"2011","journal-title":"J Mol Cell Biol"},{"key":"2026082703245873000_B42","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3109\/10409238.2013.792770","article-title":"Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability","volume":"48","author":"Popuri","year":"2013","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2026082703245873000_B43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1083\/jcb.201507099","article-title":"RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells","volume":"214","author":"Urban","year":"2016","journal-title":"J Cell Biol"},{"key":"2026082703245873000_B44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fcell.2020.00324","article-title":"RECQL5 at the intersection of replication and transcription","volume":"8","author":"Hamadeh","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026082703245873000_B45","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nsmb.2853","article-title":"RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation","volume":"21","author":"Ni","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"2026082703245873000_B46","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.1016\/j.febslet.2014.10.014","article-title":"Expanding the SRI domain family: a common scaffold for binding the phosphorylated C-terminal domain of RNA polymerase II","volume":"588","author":"Rebehmed","year":"2014","journal-title":"FEBS Lett"},{"key":"2026082703245873000_B47","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1128\/mcb.01137-10","article-title":"The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability","volume":"31","author":"Li","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2026082703245873000_B48","doi-asserted-by":"publisher","first-page":"113523","DOI":"10.1016\/j.celrep.2023.113523","article-title":"FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination","volume":"42","author":"Leung","year":"2023","journal-title":"Cell Rep"},{"key":"2026082703245873000_B49","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1038\/s41467-018-05236-y","article-title":"SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"key":"2026082703245873000_B50","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ccr.2012.05.015","article-title":"A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1\/2","volume":"22","author":"Schlacher","year":"2012","journal-title":"Cancer Cell"},{"key":"2026082703245873000_B51","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/s41467-017-01180-5","article-title":"MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells","volume":"8","author":"Lema\u00e7on","year":"2017","journal-title":"Nat Commun"},{"key":"2026082703245873000_B52","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1083\/jcb.201406099","article-title":"Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells","volume":"208","author":"Zellweger","year":"2015","journal-title":"J Cell Biol"},{"key":"2026082703245873000_B53","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41594-018-0075-z","article-title":"RPA and RAD51: fork reversal, fork protection, and genome stability","volume":"25","author":"Bhat","year":"2018","journal-title":"Nat Struct Mol Biol"},{"key":"2026082703245873000_B54","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s43018-021-00203-x","article-title":"A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors","volume":"2","author":"Zhou","year":"2021","journal-title":"Nat Cancer"},{"key":"2026082703245873000_B55","doi-asserted-by":"publisher","first-page":"7834","DOI":"10.1038\/s41467-023-43677-2","article-title":"Mechanisms of synthetic lethality between BRCA1\/2 and 53BP1 deficiencies and DNA polymerase theta targeting","volume":"14","author":"Ronson","year":"2023","journal-title":"Nat Commun"},{"key":"2026082703245873000_B56","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1016\/j.molcel.2022.11.008","article-title":"POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells","volume":"82","author":"Belan","year":"2022","journal-title":"Mol Cell"},{"key":"2026082703245873000_B57","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1038\/s41467-021-23463-8","article-title":"Pol\u03b8 inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance","volume":"12","author":"Zatreanu","year":"2021","journal-title":"Nat Commun"},{"key":"2026082703245873000_B58","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrm.2017.67","article-title":"The essential kinase ATR: ensuring faithful duplication of a challenging genome","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026082703245873000_B59","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41580-020-0257-5","article-title":"The plasticity of DNA replication forks in response to clinically relevant genotoxic stress","volume":"21","author":"Berti","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026082703245873000_B60","doi-asserted-by":"publisher","first-page":"gkaf766","DOI":"10.1093\/nar\/gkaf766","article-title":"RECQ5 mediates pre-rRNA processing in nucleolus","volume":"53","author":"Ma","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026082703245873000_B61","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.1038\/s41467-023-40779-9","article-title":"C16orf72\/HAPSTR1\/TAPR1 functions with BRCA1\/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption","volume":"14","author":"Sharma","year":"2023","journal-title":"Nat Commun"},{"key":"2026082703245873000_B62","doi-asserted-by":"publisher","first-page":"103055","DOI":"10.1016\/j.dnarep.2021.103055","article-title":"PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway","volume":"100","author":"Shen","year":"2021","journal-title":"DNA Repair"},{"key":"2026082703245873000_B63","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1038\/s41467-020-16096-w","article-title":"Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly","volume":"11","author":"Thakar","year":"2020","journal-title":"Nat Commun"},{"key":"2026082703245873000_B64","doi-asserted-by":"publisher","first-page":"108642","DOI":"10.1016\/j.pharmthera.2024.108642","article-title":"Cisplatin in the era of PARP inhibitors and immunotherapy","volume":"258","author":"Duan","year":"2024","journal-title":"Pharmacol Ther"},{"key":"2026082703245873000_B65","doi-asserted-by":"publisher","first-page":"9457","DOI":"10.1038\/s41467-025-64509-5","article-title":"Tumor-targeted top1 inhibitor delivery with optimized parp inhibition in advanced solid tumors: a phase i trial of gapped scheduling","volume":"16","author":"Thomas","year":"2025","journal-title":"Nat Commun"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag831\/70813914\/gkag831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag831\/70813914\/gkag831.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:25:04Z","timestamp":1787815504000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag831\/8771617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":65,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag831","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,9]]},"published":{"date-parts":[[2026,8,24]]},"article-number":"gkag831"}}