{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:24:08Z","timestamp":1787649848063,"version":"build-2736575974"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","award":["INCa_18519"],"award-info":[{"award-number":["INCa_18519"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Emergence Universit\u00e9 Paris Cit\u00e9"},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute Pasteur of Rome","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Italy Ministry of University and Research","award":["N 202227SYBW"],"award-info":[{"award-number":["N 202227SYBW"]}]},{"name":"Italy Ministry of University and Research","award":["N 2022KKMTL9"],"award-info":[{"award-number":["N 2022KKMTL9"]}]},{"name":"French Ministry of Higher Education Research and Innovation"},{"DOI":"10.13039\/100012948","name":"MESRI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012948","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association pour la Recherche contre le Cancer"},{"DOI":"10.13039\/100000163","name":"ARC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013501","name":"INCa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Separase plays central roles in chromosome separation during mitosis and in the centrosome duplication cycle. Tight control of separase activity is required to prevent unscheduled resolution of sister chromatid cohesion and centrosome aberrations, thereby maintaining genome stability. In mammals, despite their disassembly during early mitosis, some nuclear envelope components have mitotic roles, but the links with separase activity remain unexplored. Here, we uncover a novel mechanism of separase regulation involving lamin B1, a key nuclear envelope factor. We show that separase and lamin B1 associate preferentially during early mitotic stages. Importantly, lamin B1 depletion leads to an increase in separase recruitment to chromosomes together with premature chromatid separation, a phenotype reminiscent of separase overexpression. Conversely, similar to separase depletion, lamin B1 overexpression induces diplochromosome formation, together with centrosome amplification, phenotypes consistent with impaired sister chromatid separation. Importantly, increasing separase levels prevents lamin B1-induced centrosome aberrations, suggesting a separase defect at their origin. Indeed, we show that overexpression of lamin B1 leads to a decrease in the recruitment of separase to chromosomes and a delay in its activity. Taken together, this study unveils a novel mechanism of separase regulation involving the nuclear envelope factor lamin B1 that is critical for genome integrity.<\/jats:p>","DOI":"10.1093\/nar\/gkag841","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:47:27Z","timestamp":1786798047000},"source":"Crossref","is-referenced-by-count":0,"title":["Lamin B1-dependent regulation of human separase in mitosis"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-6023","authenticated-orcid":false,"given":"Julien","family":"Picotto","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations , LREV\/DRCM\/IBFJ, F-92260 Fontenay-aux-Roses ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, LREV\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3226-7383","authenticated-orcid":false,"given":"Laureline","family":"Urli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations , LREV\/DRCM\/IBFJ, F-92260 Fontenay-aux-Roses ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, LREV\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-5295","authenticated-orcid":false,"given":"Francesca","family":"Cipressa","sequence":"additional","affiliation":[{"name":"Department of Ecological and Biological Sciences, Universit\u00e0 della Tuscia, Largo dell\u2019Universit\u00e0 SNC , 01100 Viterbo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-7900","authenticated-orcid":false,"given":"Didier","family":"Busso","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, CiGEX\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, CiGEX\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-1411","authenticated-orcid":false,"given":"Giovanni","family":"Cenci","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnologies \u201cC. Darwin\u201d, Sapienza University of Rome , 00185 Rome ,","place":["Italy"]},{"name":"Istituto Pasteur Italia, Fondazione Cenci Bolognetti , 00161 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-742X","authenticated-orcid":false,"given":"Pascale","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations , LREV\/DRCM\/IBFJ, F-92260 Fontenay-aux-Roses ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, LREV\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-9345","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Pennarun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations , LREV\/DRCM\/IBFJ, F-92260 Fontenay-aux-Roses ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, Inserm, CEA, Stabilit\u00e9 G\u00e9n\u00e9tique, Cellules Souches et Radiations, LREV\/DRCM\/IBFJ , F-92260 Fontenay-aux-Roses ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026082505104467000_B1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0092-8674(00)00130-6","article-title":"Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast","volume":"103","author":"Uhlmann","year":"2000","journal-title":"Cell"},{"key":"2026082505104467000_B2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0092-8674(00)00132-X","article-title":"Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase","volume":"103","author":"Waizenegger","year":"2000","journal-title":"Cell"},{"key":"2026082505104467000_B3","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.1061376","article-title":"Cohesin cleavage by separase required for anaphase and cytokinesis in Human cells","volume":"293","author":"Hauf","year":"2001","journal-title":"Science"},{"key":"2026082505104467000_B4","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.4161\/cc.5.21.3407","article-title":"Nuclear exclusion of separase prevents cohesin cleavage in interphase cells","volume":"5","author":"Sun","year":"2006","journal-title":"Cell Cycle"},{"key":"2026082505104467000_B5","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.4161\/cc.8.9.8331","article-title":"Recruitment of separase to mitotic chromosomes is regulated by Aurora B","volume":"8","author":"Yuan","year":"2009","journal-title":"Cell Cycle"},{"key":"2026082505104467000_B6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41586-021-03764-0","article-title":"Structural basis of human separase regulation by securin and CDK1-cyclin B1","volume":"596","author":"Yu","year":"2021","journal-title":"Nature"},{"key":"2026082505104467000_B7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0092-8674(01)00603-1","article-title":"Dual inhibition of sister chromatid separation at metaphase","volume":"107","author":"Stemmann","year":"2001","journal-title":"Cell"},{"key":"2026082505104467000_B8","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41586-020-2182-3","article-title":"Securin-independent regulation of separase by checkpoint-induced shugoshin\u2013MAD2","volume":"580","author":"Hellmuth","year":"2020","journal-title":"Nature"},{"key":"2026082505104467000_B9","doi-asserted-by":"publisher","first-page":"e416","DOI":"10.1371\/journal.pbio.0030416","article-title":"Securin is not required for chromosomal stability in Human cells","volume":"3","author":"Pfleghaar","year":"2005","journal-title":"PLoS Biol"},{"key":"2026082505104467000_B10","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221400","article-title":"The molecular mechanisms of human separase regulation","author":"Yu","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"2026082505104467000_B11","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.3390\/ijms24054604","article-title":"Separase and roads to disengage sister chromatids during Anaphase","volume":"24","author":"Konecna","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026082505104467000_B12","doi-asserted-by":"publisher","first-page":"13033","DOI":"10.1073\/pnas.0801610105","article-title":"Overexpression of Separase induces aneuploidy and mammary tumorigenesis","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082505104467000_B13","doi-asserted-by":"publisher","first-page":"111723","DOI":"10.1016\/j.celrep.2022.111723","article-title":"Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1","volume":"41","author":"Shindo","year":"2022","journal-title":"Cell Rep"},{"key":"2026082505104467000_B14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.molcel.2015.03.025","article-title":"Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1","volume":"58","author":"Hellmuth","year":"2015","journal-title":"Mol Cell"},{"key":"2026082505104467000_B15","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1242\/jcs.03083","article-title":"Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction","volume":"119","author":"Holland","year":"2006","journal-title":"J Cell Sci"},{"key":"2026082505104467000_B16","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1083\/jcb.200506119","article-title":"Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression","volume":"172","author":"Wirth","year":"2006","journal-title":"J Cell Biol"},{"key":"2026082505104467000_B17","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1083\/jcb.200511126","article-title":"The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase","volume":"172","author":"Kumada","year":"2006","journal-title":"J Cell Biol"},{"key":"2026082505104467000_B18","doi-asserted-by":"publisher","first-page":"9152","DOI":"10.1038\/s41598-020-65975-1","article-title":"Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion","volume":"10","author":"Galofr\u00e9","year":"2020","journal-title":"Sci Rep"},{"key":"2026082505104467000_B19","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1158\/1078-0432.CCR-08-2454","article-title":"Overexpression and mislocalization of the chromosomal segregation protein separase in multiple Human cancers","volume":"15","author":"Meyer","year":"2009","journal-title":"Clin Cancer Res"},{"key":"2026082505104467000_B20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11060-014-1458-6","article-title":"Overexpression and constitutive nuclear localization of cohesin protease separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme","volume":"119","author":"Mukherjee","year":"2014","journal-title":"J Neurooncol"},{"key":"2026082505104467000_B21","doi-asserted-by":"publisher","first-page":"8381","DOI":"10.2147\/IJGM.S381188","article-title":"ESPL1 is elevated in hepatocellular carcinoma and predicts prognosis","volume":"15","author":"Song","year":"2022","journal-title":"Int J Gen Med"},{"key":"2026082505104467000_B22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/1354750X.2024.2339288","article-title":"Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer","volume":"29","author":"Yang","year":"2024","journal-title":"Biomarkers"},{"key":"2026082505104467000_B23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12935-024-03233-4","article-title":"Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib","volume":"24","author":"Zhang","year":"2024","journal-title":"Cancer Cell Int"},{"key":"2026082505104467000_B24","doi-asserted-by":"publisher","first-page":"1138077","DOI":"10.3389\/fimmu.2023.1138077","article-title":"Pan-cancer analysis and experimental validation identify the oncogenic nature of ESPL1: potential therapeutic target in colorectal cancer","volume":"14","author":"Zhong","year":"2023","journal-title":"Front Immunol"},{"key":"2026082505104467000_B25","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/S0960-9822(02)01073-4","article-title":"Regulation of Human separase by securin binding and autocleavage","volume":"12","author":"Waizenegger","year":"2002","journal-title":"Curr Biol"},{"key":"2026082505104467000_B26","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1046\/j.1365-2443.2002.00586.x","article-title":"Cut1\/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation","volume":"7","author":"Nakamura","year":"2002","journal-title":"Genes Cells"},{"key":"2026082505104467000_B27","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/hmg\/ddac235","article-title":"Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis","volume":"32","author":"Patil","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2026082505104467000_B28","doi-asserted-by":"publisher","first-page":"e202302404","DOI":"10.26508\/lsa.202302404","article-title":"The LINC complex ensures accurate centrosome positioning during prophase","volume":"7","author":"Lima","year":"2024","journal-title":"Life Sci Alliance"},{"key":"2026082505104467000_B29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0092-8674(01)00627-4","article-title":"Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina","volume":"108","author":"Beaudouin","year":"2002","journal-title":"Cell"},{"key":"2026082505104467000_B30","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1242\/jcs.110.17.2129","article-title":"Nuclear envelope breakdown in mammalian cells involves stepwise lamina disassembly and microtubule-driven deformation of the nuclear membrane","volume":"110","author":"Georgatos","year":"1997","journal-title":"J Cell Sci"},{"key":"2026082505104467000_B31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1242\/jcs.94.3.449","article-title":"A somatic cell-derived system for studying both early and late mitotic events in vitro","volume":"94","author":"Nakagawa","year":"1989","journal-title":"J Cell Sci"},{"key":"2026082505104467000_B32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/0092-8674(90)90471-P","article-title":"In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase","volume":"61","author":"Peter","year":"1990","journal-title":"Cell"},{"key":"2026082505104467000_B33","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/j.1460-2075.1991.tb07673.x","article-title":"Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase","volume":"10","author":"Peter","year":"1991","journal-title":"EMBO J"},{"key":"2026082505104467000_B34","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/0092-8674(90)90470-Y","article-title":"Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis","volume":"61","author":"Heald","year":"1990","journal-title":"Cell"},{"key":"2026082505104467000_B35","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1038\/oncsis.2014.6","article-title":"Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation","volume":"3","author":"Kuga","year":"2014","journal-title":"Oncogenesis"},{"key":"2026082505104467000_B36","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1126\/science.1122771","article-title":"A mitotic lamin B matrix induced by RanGTP required for spindle assembly","volume":"311","author":"Tsai","year":"2006","journal-title":"Science"},{"key":"2026082505104467000_B37","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/ncb1832","article-title":"A requirement of nudel and dynein for assembly of the Lamin B spindle matrix","volume":"11","author":"Ma","year":"2009","journal-title":"Nat Cell Biol"},{"key":"2026082505104467000_B38","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1101\/gad.1652708","article-title":"Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin","volume":"22","author":"Dechat","year":"2008","journal-title":"Genes Dev"},{"key":"2026082505104467000_B39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.tcb.2017.08.004","article-title":"Nuclear lamins: thin filaments with major functions","volume":"28","author":"Leeuw\u00a0de","year":"2018","journal-title":"Trends Cell Biol"},{"key":"2026082505104467000_B40","doi-asserted-by":"publisher","first-page":"eabb3799","DOI":"10.1126\/sciadv.abb3799","article-title":"Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage","volume":"7","author":"Etourneaud","year":"2021","journal-title":"Sci Adv"},{"key":"2026082505104467000_B41","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1128\/MCB.01145-14","article-title":"Role of lamin b1 in chromatin instability","volume":"35","author":"Butin-Israeli","year":"2015","journal-title":"Mol Cell Biol"},{"key":"2026082505104467000_B42","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1096\/fj.14-265546","article-title":"Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage","volume":"29","author":"Liu","year":"2015","journal-title":"FASEB J"},{"key":"2026082505104467000_B43","doi-asserted-by":"publisher","first-page":"9886","DOI":"10.1093\/nar\/gkab761","article-title":"Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells","volume":"49","author":"Pennarun","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026082505104467000_B44","doi-asserted-by":"publisher","first-page":"663","DOI":"10.2217\/fon-2020-0825","article-title":"Lamin B1 promotes tumor progression and metastasis in primary prostate cancer patients","volume":"17","author":"Luo","year":"2020","journal-title":"Future Oncol"},{"key":"2026082505104467000_B45","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1158\/1078-0432.CCR-12-3630","article-title":"Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer","volume":"19","author":"Li","year":"2013","journal-title":"Clin Cancer Res"},{"key":"2026082505104467000_B46","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1021\/pr9002118","article-title":"Circulating Lamin B1 (LMNB1) biomarker detects early stages of liver cancer in patients","volume":"9","author":"Sun","year":"2010","journal-title":"J Proteome Res"},{"key":"2026082505104467000_B47","doi-asserted-by":"publisher","first-page":"BSR20210231","DOI":"10.1042\/BSR20210231","article-title":"Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas","volume":"41","author":"Zhou","year":"2021","journal-title":"Biosci Rep"},{"key":"2026082505104467000_B48","doi-asserted-by":"publisher","first-page":"620","DOI":"10.2174\/0115680096299107240427073527","article-title":"LMNB1\/CDKN1A signaling regulates the cell cycle and promotes hepatocellular carcinoma progression","volume":"25","author":"Gao","year":"2024","journal-title":"Curr Cancer Drug Targets"},{"key":"2026082505104467000_B49","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1084\/jem.20181394","article-title":"Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET","volume":"216","author":"Jia","year":"2019","journal-title":"J Exp Med"},{"key":"2026082505104467000_B50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.stem.2022.02.010","article-title":"Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function","volume":"29","author":"Reilly","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2026082505104467000_B51","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/gut.45.5.723","article-title":"Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms","volume":"45","author":"Moss","year":"1999","journal-title":"Gut"},{"key":"2026082505104467000_B52","first-page":"2155","article-title":"Identification of bioactive small molecule inhibitors of separase","volume":"14","author":"Henschke","year":"2019","journal-title":"ACS Chem Biol"},{"key":"2026082505104467000_B53","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1093\/hmg\/ddl026","article-title":"The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers","volume":"15","author":"Delbarre","year":"2006","journal-title":"Hum Mol Genet"},{"key":"2026082505104467000_B54","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.devcel.2012.06.015","article-title":"Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition","volume":"23","author":"Shindo","year":"2012","journal-title":"Dev Cell"},{"key":"2026082505104467000_B55","first-page":"609","article-title":"Differential expression of nuclear lamins in normal and cancerous prostate tissues","volume":"15","author":"Coradeghini","year":"2006","journal-title":"Oncol Rep"},{"key":"2026082505104467000_B56","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1146\/annurev-cellbio-092910-154234","article-title":"The causes and consequences of polyploidy in normal development and cancer","volume":"27","author":"Davoli","year":"2011","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2026082505104467000_B57","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nature08136","article-title":"A mechanism linking extra centrosomes to chromosomal instability","volume":"460","author":"Ganem","year":"2009","journal-title":"Nature"},{"key":"2026082505104467000_B58","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/sj.embor.7400527","article-title":"Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects","volume":"6","author":"Tachibana","year":"2005","journal-title":"EMBO Rep"},{"key":"2026082505104467000_B59","doi-asserted-by":"publisher","first-page":"a015800","DOI":"10.1101\/cshperspect.a015800","article-title":"The Centrosome and its duplication cycle","volume":"7","author":"Fu","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026082505104467000_B60","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cell.2009.01.040","article-title":"Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner","volume":"137","author":"Sun","year":"2009","journal-title":"Cell"},{"key":"2026082505104467000_B61","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1038\/s41467-018-05912-z","article-title":"Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains","volume":"9","author":"Pascual-Reguant","year":"2018","journal-title":"Nat Commun"},{"key":"2026082505104467000_B62","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tcb.2016.07.008","article-title":"Time to split up: dynamics of chromosome separation","volume":"27","author":"Kamenz","year":"2017","journal-title":"Trends Cell Biol"},{"key":"2026082505104467000_B63","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/ncb1303","article-title":"Multiple roles for separase auto-cleavage during the G2\/M transition","volume":"7","author":"Papi","year":"2005","journal-title":"Nat Cell Biol"},{"key":"2026082505104467000_B64","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41420-025-02758-5","article-title":"An evolutionarily conserved role for separase in the regulation of nuclear lamins","volume":"11","author":"Cipressa","year":"2025","journal-title":"Cell Death Discov"},{"key":"2026082505104467000_B65","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1083\/jcb.201706061","article-title":"Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging","volume":"217","author":"Serebryannyy","year":"2018","journal-title":"J Cell Biol"},{"key":"2026082505104467000_B66","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1083\/jcb.200804155","article-title":"Lamin B1 controls oxidative stress responses via Oct-1","volume":"184","author":"Malhas","year":"2009","journal-title":"J Cell Biol"},{"key":"2026082505104467000_B67","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.4161\/cc.19944","article-title":"Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells","volume":"11","author":"Wilsker","year":"2012","journal-title":"Cell Cycle"},{"key":"2026082505104467000_B68","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2010.01.031","article-title":"Persistent telomere damage induces bypass of mitosis and tetraploidy","volume":"141","author":"Davoli","year":"2010","journal-title":"Cell"},{"key":"2026082505104467000_B69","doi-asserted-by":"publisher","first-page":"e15204","DOI":"10.7554\/eLife.15204","article-title":"Distinct responses to reduplicated chromosomes require distinct Mad2 responses","volume":"5","author":"Stormo","year":"2016","journal-title":"eLife"},{"key":"2026082505104467000_B70","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/s42003-025-09081-w","article-title":"Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation","volume":"8","author":"Picotto","year":"2025","journal-title":"Commun Biol"},{"key":"2026082505104467000_B71","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1073\/pnas.0406289102","article-title":"Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1","volume":"102","author":"Reina-San-Martin","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026082505104467000_B72","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/sj.emboj.7600087","article-title":"XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells","volume":"23","author":"Yoshihara","year":"2004","journal-title":"EMBO J"},{"key":"2026082505104467000_B73","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2006.04.044","article-title":"Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres","volume":"126","author":"Hockemeyer","year":"2006","journal-title":"Cell"},{"key":"2026082505104467000_B74","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1128\/MCB.01498-09","article-title":"Telomere protection by TPP1 is mediated by POT1a and POT1b","volume":"30","author":"Kibe","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2026082505104467000_B75","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1101\/gad.1453606","article-title":"Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication","volume":"20","author":"Lazzerini\u00a0Denchi","year":"2006","journal-title":"Genes Dev"},{"key":"2026082505104467000_B76","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nature13277","article-title":"Oncogene-like induction of cellular invasion from centrosome amplification","volume":"510","author":"Godinho","year":"2014","journal-title":"Nature"},{"key":"2026082505104467000_B77","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.cell.2008.05.039","article-title":"Centrosome amplification can initiate tumorigenesis in flies","volume":"133","author":"Basto","year":"2008","journal-title":"Cell"},{"key":"2026082505104467000_B78","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.devcel.2016.12.022","article-title":"Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals","volume":"40","author":"Levine","year":"2017","journal-title":"Dev Cell"},{"key":"2026082505104467000_B79","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1091\/mbc.12.5.1315","article-title":"Tetraploid State induces p53-dependent arrest of nontransformed mammalian cells in G1","volume":"12","author":"Andreassen","year":"2001","journal-title":"Mol Biol Cell"},{"key":"2026082505104467000_B80","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1242\/jcs.039537","article-title":"The consequences of tetraploidy and aneuploidy","volume":"121","author":"Storchova","year":"2008","journal-title":"J Cell Sci"},{"key":"2026082505104467000_B81","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1091\/mbc.e14-03-0844","article-title":"Failure of cell cleavage induces senescence in tetraploid primary cells","volume":"25","author":"Panopoulos","year":"2014","journal-title":"Mol Biol Cell"},{"key":"2026082505104467000_B82","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1038\/sj.emboj.7601127","article-title":"Apoptosis regulation in tetraploid cancer cells","volume":"25","author":"Castedo","year":"2006","journal-title":"EMBO J"},{"key":"2026082505104467000_B83","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/15384101.2015.1127469","article-title":"Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication","volume":"15","author":"De\u00a0Santis\u00a0Puzzonia","year":"2015","journal-title":"Cell Cycle"},{"key":"2026082505104467000_B84","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1091\/mbc.e16-05-0268","article-title":"Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53","volume":"27","author":"Potapova","year":"2016","journal-title":"Mol Biol Cell"},{"key":"2026082505104467000_B85","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1080\/15384101.2015.1068482","article-title":"Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells","volume":"14","author":"Kuznetsova","year":"2015","journal-title":"Cell Cycle"},{"key":"2026082505104467000_B86","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s00018-021-04084-2","article-title":"The wide and growing range of lamin B-related diseases: from laminopathies to cancer","volume":"79","author":"Evangelisti","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"2026082505104467000_B87","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s12195-016-0437-8","article-title":"Nuclear lamins in cancer","volume":"9","author":"Irianto","year":"2016","journal-title":"Cell Mol Bioeng"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag841\/70775875\/gkag841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag841\/70775875\/gkag841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:10:57Z","timestamp":1787649057000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag841\/8769956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":87,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag841","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,9]]},"published":{"date-parts":[[2026,8,24]]},"article-number":"gkag841"}}