{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:15:16Z","timestamp":1788426916785,"version":"build-2803163510"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["469281184"],"award-info":[{"award-number":["469281184"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB1565"],"award-info":[{"award-number":["SFB1565"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advanced Grants MiXpress"},{"DOI":"10.13039\/501100004189","name":"Max Planck Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020559","name":"Institut Polytechnique de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RC pour la Recherche sur le Cancer"},{"DOI":"10.13039\/501100004794","name":"Centre National pour la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agence Nationale pour la Recherche","award":["ANR-22-CE12-0010-01"],"award-info":[{"award-number":["ANR-22-CE12-0010-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Modified nucleotides are essential determinants of RNA function, and identifying the enzymes that install them is fundamental to understanding their cellular roles. Here, we show that the human RNA methyltransferase TRMT11 and its cofactor TRMT112 are imported into mitochondria via N-terminal targeting signals. Using a recently developed N2-methylguanosine (m2G)-sensitive DNAzyme, we demonstrate that TRMT11 catalytic activity and interaction with TRMT112 are required for installation of m2G at position 10 in 13 mitochondrial (mt-)tRNAs. The crosslinking profile of TRMT11 on mt-tRNAs experimentally supports a model of the TRMT11\u2013TRMT112\u2013mt-tRNATrp complex in which the THUMP domain contacts the 3\u2032 end of the acceptor stem, and G10 is flipped into the S-adenosylmethionine binding pocket for methylation. Transcriptome-wide mapping reveals that TRMT11 interacts with most nuclear-encoded and mt-tRNAs, but only methylates a subset. In vitro reconstitution of TRMT11\u2013TRM112-mediated methylation defines key structural requirements for m2G10 installation across different mt-tRNAs, and reveals how pathogenic mutations influence this modification. TRMT11\u2013TRMT112 recognizes folded mt-tRNAs, and in the degenerate mt-tRNALys, m1A9 strongly enhances m2G10 methylation efficiency. Loss of m2G10 modifications alters the conformation of numerous mt-tRNAs, perturbs mitochondrial protein synthesis, and impairs oxidative phosphorylation, highlighting an essential role of this modification in maintaining mitochondrial function.<\/jats:p>","DOI":"10.1093\/nar\/gkag859","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:33:04Z","timestamp":1788424384000},"source":"Crossref","is-referenced-by-count":0,"title":["Guanosine 10 methylation by TRMT11\u2013TRMT112 optimizes human mitochondrial tRNAs for efficient translation"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-7289","authenticated-orcid":false,"given":"Jonny","family":"Petrosyan","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University Medical Centre G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry, University Medical Centre G\u00f6ttingen , Humboldtallee 23, 37073 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7822-2066","authenticated-orcid":false,"given":"Carolin P M","family":"Scheitl","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, Universit\u00e4t Wu\u0308rzburg , Am Hubland, 97074 Wu\u0308rzburg ,","place":["Germany"]},{"name":"Cluster for Nucleic Acid Sciences and Technologies\u2014NUCLEATE , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-1656","authenticated-orcid":false,"given":"Nicolas","family":"Lemus-Diaz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University Medical Centre G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Boshnakovska","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry, University Medical Centre G\u00f6ttingen , Humboldtallee 23, 37073 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7666-0031","authenticated-orcid":false,"given":"Laurianne L E","family":"Tay","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, \u00c9cole Polytechnique, Institut Polytechnique de Paris , 91120 Palaiseau ,","place":["France"]},{"name":"Laboratoire de Chimie Moleculaire (LCM), CNRS, Ecole Polytechnique, Institut Polytechnique de Paris , 91120 Palaiseau ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, \u00c9cole Polytechnique, Institut Polytechnique de Paris , 91120 Palaiseau ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Beine-Golovchuk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University Medical Centre G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Touboul","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Moleculaire (LCM), CNRS, Ecole Polytechnique, Institut Polytechnique de Paris , 91120 Palaiseau ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Richter-Dennerlein","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University Medical Centre G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]},{"name":"G\u00f6ttingen Center for Molecular Biosciences, Georg-August University G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cMultiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u201d (MBExC), University of G\u00f6ttingen , 37075 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-2299","authenticated-orcid":false,"given":"Claudia","family":"H\u00f6bartner","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, Universit\u00e4t Wu\u0308rzburg , Am Hubland, 97074 Wu\u0308rzburg ,","place":["Germany"]},{"name":"Cluster for Nucleic Acid Sciences and Technologies\u2014NUCLEATE , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-5852","authenticated-orcid":false,"given":"Marc","family":"Graille","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, \u00c9cole Polytechnique, Institut Polytechnique de Paris , 91120 Palaiseau ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-5272","authenticated-orcid":false,"given":"Peter","family":"Rehling","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry, University Medical Centre G\u00f6ttingen , Humboldtallee 23, 37073 G\u00f6ttingen ,","place":["Germany"]},{"name":"G\u00f6ttingen Center for Molecular Biosciences, Georg-August University G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cMultiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells\u201d (MBExC), University of G\u00f6ttingen , 37075 G\u00f6ttingen ,","place":["Germany"]},{"name":"Translational Neuroinflammation and Automated Microscopy, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP , 37075 G\u00f6ttingen ,","place":["Germany"]},{"name":"Max Planck Institute for Multidisciplinary Sciences , 37077 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-4255","authenticated-orcid":false,"given":"Katherine E","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University Medical Centre G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]},{"name":"G\u00f6ttingen Center for Molecular Biosciences, Georg-August University G\u00f6ttingen , Justus-von-Liebig-Weg 11, 37077 G\u00f6ttingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026090304325774000_B1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.cell.2026.01.006","article-title":"RNA modifications in gene regulation: functions and pathways","volume":"189","author":"Wei","year":"2026","journal-title":"Cell"},{"key":"2026090304325774000_B2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev-biochem-030222-112310","article-title":"How natural enzymes and synthetic ribozymes generate methylated nucleotides in RNA","volume":"93","author":"H\u00f6bartner","year":"2024","journal-title":"Annu Rev Biochem"},{"key":"2026090304325774000_B3","doi-asserted-by":"publisher","first-page":"217159","DOI":"10.1016\/j.canlet.2024.217159","article-title":"RNA ac4C modification in cancer: unraveling multifaceted roles and promising therapeutic horizons","volume":"601","author":"Ouyang","year":"2024","journal-title":"Cancer Lett"},{"key":"2026090304325774000_B4","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1261\/rna.079975.124","article-title":"Recent developments, opportunities, and challenges in the study of mRNA pseudouridylation","volume":"30","author":"Gilbert","year":"2024","journal-title":"RNA"},{"key":"2026090304325774000_B5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s12276-025-01633-8","article-title":"Two codes of RNA editing by deamination in human diseases","volume":"58","author":"Min","year":"2026","journal-title":"Exp Mol Med"},{"key":"2026090304325774000_B6","doi-asserted-by":"crossref","first-page":"e202400213","DOI":"10.1002\/bies.202400213","article-title":"Queuosine tRNA modification: connecting the microbiome to the translatome","volume":"47","author":"Rashad","year":"2025","journal-title":"Bioessays"},{"key":"2026090304325774000_B7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13059-026-04009-x","article-title":"Decoding human tRNA modifications and crosstalk by enhanced single-read analysis","volume":"27","author":"Assari","year":"2026","journal-title":"Genome Biol"},{"key":"2026090304325774000_B8","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41580-021-00342-0","article-title":"The expanding world of tRNA modifications and their disease relevance","volume":"22","author":"Suzuki","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090304325774000_B9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3390\/genes15030374","article-title":"Beyond the anticodon: tRNA core modifications and their impact on structure, translation and stress adaptation","volume":"15","author":"Yared","year":"2024","journal-title":"Genes"},{"key":"2026090304325774000_B10","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1007\/s00018-021-03948-x","article-title":"Modifications of the human tRNA anticodon loop and their associations with genetic diseases","volume":"78","author":"Zhou","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"2026090304325774000_B11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00018-017-2598-6","article-title":"The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease","volume":"75","author":"Bohnsack","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"2026090304325774000_B12","first-page":"1460913","article-title":"N2-methylguanosine and N2, N2-dimethylguanosine in cytosolic and mitochondrial tRNAsfront","volume":"2","author":"Petrosyan","year":"2024","journal-title":"RNA Res"},{"key":"2026090304325774000_B13","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/0006-291\u00d7(78)91666-2","article-title":"Conformation of N2-methylguanosine, a modified nucleoside of tRNA","volume":"84","author":"Ginell","year":"1978","journal-title":"Biochem Biophys Res Commun"},{"key":"2026090304325774000_B14","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1093\/nar\/26.16.3640","article-title":"N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops","volume":"26","author":"Rife","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B15","doi-asserted-by":"publisher","first-page":"11900","DOI":"10.1093\/nar\/gkab927","article-title":"THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates","volume":"49","author":"Yang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B16","doi-asserted-by":"publisher","first-page":"D219","DOI":"10.1093\/nar\/gkaf1284","article-title":"MODOMICS: a database of RNA modifications and related information. 2025 update and 20th anniversary","volume":"54","author":"Sordyl","year":"2026","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B17","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1038\/s41467-020-18068-6","article-title":"Complete chemical structures of human mitochondrial tRNAs","volume":"11","author":"Suzuki","year":"2020","journal-title":"Nat Commun"},{"key":"2026090304325774000_B18","doi-asserted-by":"crossref","first-page":"e00214","DOI":"10.1128\/MCB.00214-17","article-title":"TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival","volume":"37","author":"Dewe","year":"2017","journal-title":"Mol Cell Biol"},{"key":"2026090304325774000_B19","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.1093\/nar\/gkw561","article-title":"Structural and functional analyses of the archaeal tRNA m2G\/m22G10 methyltransferase aTrm11 provide mechanistic insights into site specificity of a tRNA methyltransferase that contains common RNA-binding modules","volume":"44","author":"Hirata","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B20","doi-asserted-by":"publisher","first-page":"11068","DOI":"10.1093\/nar\/gkaa830","article-title":"Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator","volume":"48","author":"Wang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B21","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1093\/nar\/gkad1243","article-title":"THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration","volume":"52","author":"Yang","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B22","doi-asserted-by":"publisher","first-page":"7496","DOI":"10.1093\/nar\/gkad487","article-title":"N2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing","volume":"51","author":"Wang","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B23","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1038\/s41467-026-72355-2","article-title":"2\u2032-O-Methylation-dependent installation of N2-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly","volume":"17","author":"Kleiber","year":"2026","journal-title":"Nat Commun"},{"key":"2026090304325774000_B24","doi-asserted-by":"publisher","first-page":"115167","DOI":"10.1016\/j.celrep.2024.115167","article-title":"TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress","volume":"44","author":"Hwang","year":"2025","journal-title":"Cell Rep"},{"key":"2026090304325774000_B25","doi-asserted-by":"publisher","first-page":"115092","DOI":"10.1016\/j.celrep.2024.115092","article-title":"Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs","volume":"44","author":"Zhang","year":"2025","journal-title":"Cell Rep"},{"key":"2026090304325774000_B26","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.ajhg.2025.03.015","article-title":"Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder","volume":"112","author":"Efthymiou","year":"2025","journal-title":"Am Hum Genet"},{"key":"2026090304325774000_B27","doi-asserted-by":"publisher","first-page":"13593","DOI":"10.3390\/ijms222413593","article-title":"Human TRMT112-methyltransferase network consists of seven partners interacting with a common co-factor","volume":"22","author":"Br\u016bmele","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026090304325774000_B28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/biom7010007","article-title":"Trm112, a protein activator of methyltransferases modifying actors of the eukaryotic translational apparatus","volume":"7","author":"Bourgeois","year":"2017","journal-title":"Biomolecules"},{"key":"2026090304325774000_B29","doi-asserted-by":"publisher","first-page":"1556979","DOI":"10.3389\/frnar.2025.1556979","article-title":"TRMT112, a master activator of several methyltransferases modifying factors involved in RNA maturation and translation","volume":"3","author":"Wang","year":"2025","journal-title":"Front RNA Res"},{"key":"2026090304325774000_B30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41421-019-0121-y","article-title":"Structural insight into human N6amt1\u2013Trm112 complex functioning as a protein methyltransferase","volume":"5","author":"Li","year":"2019","journal-title":"Cell Discov"},{"key":"2026090304325774000_B31","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1093\/nar\/gkr176","article-title":"Mechanism of activation of methyltransferases involved in translation by the Trm112 \u2018hub\u2019 protein","volume":"39","author":"Liger","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B32","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1093\/nar\/gkz619","article-title":"The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112","volume":"47","author":"van\u00a0Tran","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B33","doi-asserted-by":"crossref","first-page":"E5518","DOI":"10.1073\/pnas.1413089111","article-title":"Structural and functional studies of Bud23\u2013Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes","volume":"111","author":"L\u00e9toquart","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026090304325774000_B34","first-page":"1971","article-title":"Activation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112","volume":"45","author":"Bourgeois","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat Methods"},{"key":"2026090304325774000_B36","doi-asserted-by":"crossref","first-page":"e935","DOI":"10.21769\/BioProtoc.935","article-title":"Bimolecular fluorescence complementation (BiFC) assay for direct visualization of protein\u2013protein interaction in vivo","volume":"3","author":"Lai","year":"2013","journal-title":"Bio Protoc"},{"key":"2026090304325774000_B37","doi-asserted-by":"publisher","first-page":"e1009407","DOI":"10.1371\/journal.pgen.1009407","article-title":"DEAD-box RNA helicase Dbp4\/DDX10 is an enhancer of \u03b1-synuclein toxicity and oligomerization","volume":"17","author":"Popova","year":"2021","journal-title":"PLoS Genet"},{"key":"2026090304325774000_B38","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1101\/gad.862301","article-title":"RNA interference is mediated by 21- and 22-nucleotide RNAs","volume":"15","author":"Elbashir","year":"2001","journal-title":"Genes Dev"},{"key":"2026090304325774000_B39","doi-asserted-by":"publisher","first-page":"101590","DOI":"10.1016\/j.jbc.2022.101590","article-title":"The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation","volume":"298","author":"Sepich-Poore","year":"2022","journal-title":"J Biol Chem"},{"key":"2026090304325774000_B40","doi-asserted-by":"publisher","first-page":"12929","DOI":"10.1093\/nar\/gkaa1132","article-title":"Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes","volume":"48","author":"Lavdovskaia","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-4939-6807-7_18","article-title":"Crosslinking methods to identify RNA methyltransferase targets in vivo","volume":"1562","author":"Haag","year":"2017","journal-title":"Methods Mol Biol"},{"key":"2026090304325774000_B42","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/gb-2014-15-1-r8","article-title":"PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast","volume":"15","author":"Webb","year":"2014","journal-title":"Genome Biol"},{"key":"2026090304325774000_B43","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.molcel.2018.04.017","article-title":"Global maps of ProQ binding in vivo reveal target recognition via RNA structure and stability control at mRNA 3\u2032 ends","volume":"70","author":"Holmqvist","year":"2018","journal-title":"Mol Cell"},{"key":"2026090304325774000_B44","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2019","journal-title":"Bioinformatics"},{"key":"2026090304325774000_B45","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1093\/bioinformatics\/btac198","article-title":"tRNAstudio: facilitating the study of human mature tRNAs from deep sequencing datasets","volume":"38","author":"Murillo-Recio","year":"2022","journal-title":"Bioinformatics"},{"key":"2026090304325774000_B46","doi-asserted-by":"publisher","first-page":"33664","DOI":"10.1074\/jbc.M203834200","article-title":"Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel*","volume":"277","author":"Carre\u00e1","year":"2002","journal-title":"J Biol Chem"},{"key":"2026090304325774000_B47","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00706-003-0592-1","article-title":"The synthesis of 2\u2032-O-[(triisopropylsilyl)oxy] methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis","volume":"134","author":"H\u00f6bartner","year":"2003","journal-title":"Monatshefte f\u00fcr Chemie"},{"key":"2026090304325774000_B48","doi-asserted-by":"publisher","first-page":"pdb.prot078535","DOI":"10.1101\/pdb.prot078535","article-title":"High-yield synthesis of RNA using T7 RNA polymerase and plasmid DNA or oligonucleotide templates","volume":"2013","author":"Nilsen","year":"2013","journal-title":"Cold Spring Harb Protoc"},{"key":"2026090304325774000_B49","doi-asserted-by":"publisher","first-page":"19546","DOI":"10.1021\/jacs.9b10531","article-title":"Direct in vitro selection of trans-acting ribozymes for posttranscriptional, site-specific, and covalent fluorescent labeling of RNA","volume":"141","author":"Ghaem\u00a0Maghami","year":"2019","journal-title":"J Am Chem Soc"},{"key":"2026090304325774000_B50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-61779-949-5_19","article-title":"Analysis of Aminoacyl- and Peptidyl-tRNAs by Gel Electrophoresis","volume-title":"Bacterial Regulatory RNA: Methods and Protocols","author":"Janssen","year":"2012"},{"key":"2026090304325774000_B51","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"2026090304325774000_B52","article-title":"Deep confident steps to new pockets: strategies for docking generalization","author":"Corso"},{"key":"2026090304325774000_B53","article-title":"ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps - PubMed"},{"key":"2026090304325774000_B54","doi-asserted-by":"publisher","first-page":"e4792","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci"},{"key":"2026090304325774000_B55","doi-asserted-by":"publisher","first-page":"e202200212","DOI":"10.1002\/cbic.202200212","article-title":"Methyltransferases: functions and applications","volume":"23","author":"Abdelraheem","year":"2022","journal-title":"ChemBioChem"},{"key":"2026090304325774000_B56","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0968-0004(03)00090-2","article-title":"Many paths to methyltransfer: a chronicle of convergence","volume":"28","author":"Schubert","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"2026090304325774000_B57","doi-asserted-by":"publisher","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B58","doi-asserted-by":"publisher","first-page":"D1225","DOI":"10.1093\/nar\/gky1072","article-title":"MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases","volume":"47","author":"Smith","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B59","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1083\/jcb.140.4.821","article-title":"Rapid diffusion of green fluorescent protein in the mitochondrial matrix","volume":"140","author":"Partikian","year":"1998","journal-title":"J Cell Biol"},{"key":"2026090304325774000_B60","doi-asserted-by":"publisher","first-page":"13593","DOI":"10.3390\/ijms222413593","article-title":"Human TRMT112-methyltransferase network consists of seven partners interacting with a common co-factor","volume":"22","author":"Br\u016bmele","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026090304325774000_B61","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1083\/jcb.201507125","article-title":"Mitochondrial RNA granules: compartmentalizing mitochondrial gene expression","volume":"212","author":"Jourdain","year":"2016","journal-title":"J Cell Biol"},{"key":"2026090304325774000_B62","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.bbamcr.2012.05.028","article-title":"Mitochondrial protein import: common principles and physiological networks","volume":"1833","author":"Dudek","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2026090304325774000_B63","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1074\/mcp.M114.043083","article-title":"MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites","volume":"14","author":"Fukasawa","year":"2015","journal-title":"Mol Cell Proteomics"},{"key":"2026090304325774000_B64","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.str.2022.11.012","article-title":"Benchmarking AlphaFold2 on peptide structure prediction","volume":"31","author":"McDonald","year":"2023","journal-title":"Structure"},{"key":"2026090304325774000_B65","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1128\/MCB.25.11.4359-4370.2005","article-title":"Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA","volume":"25","author":"Purushothaman","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2026090304325774000_B66","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.jmb.2007.08.053","article-title":"Crystal structure of human Pus10, a novel pseudouridine synthase","volume":"373","author":"McCleverty","year":"2007","journal-title":"J Mol Biol"},{"key":"2026090304325774000_B67","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.1093\/nar\/gku249","article-title":"Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification","volume":"42","author":"Neumann","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B68","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.1093\/nar\/gks163","article-title":"Crystal structures of the tRNA:m2G6 methyltransferase Trm14\/TrmN from two domains of life","volume":"40","author":"Fislage","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B69","doi-asserted-by":"publisher","first-page":"35236","DOI":"10.1074\/jbc.M111.253641","article-title":"Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure","volume":"286","author":"Awai","year":"2011","journal-title":"J Biol Chem"},{"key":"2026090304325774000_B70","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41594-021-00637-y","article-title":"Structural basis of RNA processing by human mitochondrial RNase P","volume":"28","author":"Bhatta","year":"2021","journal-title":"Nat Struct Mol Biol"},{"key":"2026090304325774000_B71","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41594-024-01445-w","article-title":"Molecular basis of human nuclear and mitochondrial tRNA 3\u2032 processing","volume":"32","author":"Bhatta","year":"2025","journal-title":"Nat Struct Mol Biol"},{"key":"2026090304325774000_B72","doi-asserted-by":"publisher","first-page":"40041","DOI":"10.1074\/jbc.M106202200","article-title":"Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases","volume":"276","author":"Nagaike","year":"2001","journal-title":"J Biol Chem"},{"key":"2026090304325774000_B73","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1038\/s41467-024-49132-0","article-title":"Structural basis for human mitochondrial tRNA maturation","volume":"15","author":"Meynier","year":"2024","journal-title":"Nat Commun"},{"key":"2026090304325774000_B74","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.3390\/ijms23074046","article-title":"Required elements in tRNA for methylation by the eukaryotic tRNA (guanine-N2-) methyltransferase (Trm11-Trm112 Complex)","volume":"23","author":"Nishida","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026090304325774000_B75","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00018-017-2598-6","article-title":"The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease","volume":"75","author":"Bohnsack","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"2026090304325774000_B76","doi-asserted-by":"publisher","first-page":"12023","DOI":"10.3390\/ijms262412023","article-title":"Mitochondrial tRNA-derived diseases","volume":"26","author":"Petropoulou","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026090304325774000_B77","doi-asserted-by":"publisher","first-page":"D823","DOI":"10.1093\/nar\/gkl927","article-title":"An enhanced MITOMAP with a global mtDNA mutational phylogeny","volume":"35","author":"Ruiz-Pesini","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B78","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1111\/ene.15814","article-title":"Phenotyping mitochondrial DNA-related diseases in childhood: a cohort study of 150 patients","volume":"30","author":"Ardissone","year":"2023","journal-title":"Eur J Neurol"},{"key":"2026090304325774000_B79","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3109\/19401736.2013.803086","article-title":"A novel MT-CO2 m.8249G&gt;A pathogenic variation and the MT-TW m.5521G&gt;A mutation in patients with mitochondrial myopathy","volume":"25","author":"Mkaouar-Rebai","year":"2014","journal-title":"Mitochondrial DNA"},{"key":"2026090304325774000_B80","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/ejhg.2009.169","article-title":"Functional consequences of mitochondrial tRNATrp and tRNAArg mutations causing combined OXPHOS defects","volume":"18","author":"Smits","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"2026090304325774000_B81","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/jmedgenet-2016-103876","article-title":"De novo mtDNA point mutations are common and have a low recurrence risk","volume":"54","author":"Sallevelt","year":"2017","journal-title":"J Med Genet"},{"key":"2026090304325774000_B82","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jns.2008.01.016","article-title":"A novel tRNA(Val) mitochondrial DNA mutation causing MELAS","volume":"270","author":"Tanji","year":"2008","journal-title":"J Neurol Sci"},{"key":"2026090304325774000_B83","first-page":"460","article-title":"A novel mtDNA point mutation in tRNA(Val) is associated with hypertrophic cardiomyopathy and MELAS","volume":"5","author":"Menotti","year":"2004","journal-title":"Ital Heart J"},{"key":"2026090304325774000_B84","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1001\/archneur.59.6.1013","article-title":"Complex neurologic syndrome associated with the G1606A mutation of mitochondrial DNA","volume":"59","author":"Sacconi","year":"2002","journal-title":"Arch Neurol"},{"key":"2026090304325774000_B85","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1007\/s00415-009-5023-8","article-title":"Heteroplasmic mutation in the anticodon-stem of mitochondrial tRNAVal causing MNGIE-like gastrointestinal dysmotility and cachexia","volume":"256","author":"Horv\u00e1th","year":"2009","journal-title":"J Neurol"},{"key":"2026090304325774000_B86","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.mito.2011.04.003","article-title":"Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes","volume":"11","author":"Glatz","year":"2011","journal-title":"Mitochondrion"},{"key":"2026090304325774000_B87","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41586-020-2854-z","article-title":"Site-specific RNA methylation by a methyltransferase ribozyme","volume":"587","author":"Scheitl","year":"2020","journal-title":"Nature"},{"key":"2026090304325774000_B88","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41589-022-00976-x","article-title":"Structure and mechanism of the methyltransferase ribozyme MTR1","volume":"18","author":"Scheitl","year":"2022","journal-title":"Nat Chem Biol"},{"key":"2026090304325774000_B89","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.chembiol.2011.03.016","article-title":"Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys)","volume":"18","author":"Kobitski","year":"2011","journal-title":"Chem Biol"},{"key":"2026090304325774000_B90","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1093\/nar\/26.7.1636","article-title":"The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA","volume":"26","author":"Helm","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B91","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41467-021-27905-1","article-title":"The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr\/Ser(UCN) to optimise tRNA structure and mitochondrial translation","volume":"13","author":"Kleiber","year":"2022","journal-title":"Nat Commun"},{"key":"2026090304325774000_B92","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/s41580-026-00948-2","article-title":"Mechanisms and disease relevance of mitochondrial translation in humans","volume":"27","author":"Richter-Dennerlein","year":"2026","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090304325774000_B93","doi-asserted-by":"publisher","first-page":"eadr3498","DOI":"10.1126\/science.adr3498","article-title":"Silencing mitochondrial gene expression in living cells","volume":"389","author":"Cruz-Zaragoza","year":"2025","journal-title":"Science"},{"key":"2026090304325774000_B94","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev-genet-110410-132531","article-title":"Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases","volume":"45","author":"Suzuki","year":"2011","journal-title":"Annu Rev Genet"},{"key":"2026090304325774000_B95","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkag736","article-title":"Concurrent detection of chemically modified bases in yeast mitochondrial tRNAs by Nanopore direct RNA sequencing","author":"Reinsch","year":"2025.","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B96","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.3390\/ijms16034518","article-title":"tRNA biology in mitochondria","volume":"16","author":"Salinas-Gieg\u00e9","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2026090304325774000_B97","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/nsmb.2357","article-title":"RNA cytosine methylation by DNMT2 and NSUN2 promotes tRNA stability and protein synthesis","volume":"19","author":"Tuorto","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"2026090304325774000_B98","doi-asserted-by":"publisher","first-page":"8734","DOI":"10.1093\/nar\/gkz575","article-title":"Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs","volume":"47","author":"Shinoda","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B99","doi-asserted-by":"publisher","first-page":"7346","DOI":"10.1093\/nar\/gku390","article-title":"A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs","volume":"42","author":"Suzuki","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B100","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41586-022-04765-3","article-title":"Defining mitochondrial protein functions through deep multiomic profiling","volume":"606","author":"Rensvold","year":"2022","journal-title":"Nature"},{"key":"2026090304325774000_B101","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1016\/j.febslet.2008.05.045","article-title":"HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1","volume":"582","author":"Figaro","year":"2008","journal-title":"FEBS Lett"},{"key":"2026090304325774000_B102","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.febslet.2009.11.049","article-title":"Do all modifications benefit all tRNAs?","volume":"584","author":"Phizicky","year":"2010","journal-title":"FEBS Lett"},{"key":"2026090304325774000_B103","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.celrep.2015.01.030","article-title":"Mitochondrial RNA granules are centers for posttranscriptional RNA processing and ribosome biogenesis","volume":"10","author":"Antonicka","year":"2015","journal-title":"Cell Rep"},{"key":"2026090304325774000_B104","doi-asserted-by":"publisher","first-page":"7981","DOI":"10.1093\/nar\/gkaa548","article-title":"The methyltransferase TrmA facilitates tRNA folding through interaction with its RNA-binding domain","volume":"48","author":"Keffer-Wilkes","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B105","doi-asserted-by":"publisher","first-page":"14306","DOI":"10.1073\/pnas.1607512113","article-title":"RNA modification enzyme TruB is a tRNA chaperone","volume":"113","author":"Keffer-Wilkes","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026090304325774000_B106","doi-asserted-by":"crossref","article-title":"Mechanism of human tRNA 3\u2032CCA maturation","author":"Kuhle","DOI":"10.64898\/2026.03.02.709036"},{"key":"2026090304325774000_B107","doi-asserted-by":"publisher","first-page":"13382","DOI":"10.1021\/ja075520+","article-title":"A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys)","volume":"129","author":"Voigts-Hoffmann","year":"2007","journal-title":"J Am Chem Soc"},{"key":"2026090304325774000_B108","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1093\/nar\/gkp697","article-title":"Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny","volume":"37","author":"Messmer","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B109","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/nar\/22.3.347","article-title":"Higher-order structure of bovine mitochondrial tRNA Phe lacking the \u2018conserved\u2019 GG and T\u03a8CG sequences as inferred by enzymatic and chemical probing","volume":"22","author":"Wakita","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B110","doi-asserted-by":"publisher","first-page":"eadm9238","DOI":"10.1126\/science.adm9238","article-title":"The human mitochondrial mRNA structurome reveals mechanisms of gene expression","volume":"385","author":"Moran","year":"2024","journal-title":"Science"},{"key":"2026090304325774000_B111","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.semcdb.2017.08.055","article-title":"Mitochondrial cytochrome c oxidase biogenesis: recent developments","volume":"76","author":"Tim\u00f3n-G\u00f3mez","year":"2018","journal-title":"Semin Cell Dev Biol"},{"key":"2026090304325774000_B112","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander\u00a0Heiden","year":"2009","journal-title":"Science"},{"key":"2026090304325774000_B113","doi-asserted-by":"publisher","first-page":"e28536","DOI":"10.1371\/journal.pone.0028536","article-title":"Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells","volume":"6","author":"Aguer","year":"2011","journal-title":"PLoS One"},{"key":"2026090304325774000_B114","doi-asserted-by":"publisher","first-page":"gkaf1311","DOI":"10.1093\/nar\/gkaf1311","article-title":"Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants","volume":"53","author":"Wu","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026090304325774000_B115","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1111\/ene.15814","article-title":"Phenotyping mitochondrial DNA-related diseases in childhood: a cohort study of 150 patients","volume":"30","author":"Ardissone","year":"2023","journal-title":"Euro J Neurol"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag859\/70935337\/gkag859.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/16\/gkag859\/70935337\/gkag859.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:33:14Z","timestamp":1788424394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag859\/8780936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":115,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag859","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,9]]},"published":{"date-parts":[[2026,8,24]]},"article-number":"gkag859"}}