{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:04:23Z","timestamp":1790330663932,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2025ZD0552017"],"award-info":[{"award-number":["2025ZD0552017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472841"],"award-info":[{"award-number":["82472841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503866"],"award-info":[{"award-number":["82503866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7254340"],"award-info":[{"award-number":["7254340"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7254342"],"award-info":[{"award-number":["7254342"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7262011"],"award-info":[{"award-number":["7262011"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7264241"],"award-info":[{"award-number":["7264241"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Administrative Commission of Zhongguancun Science Park","award":["Z241100009024044"],"award-info":[{"award-number":["Z241100009024044"]}],"id":[{"id":"https:\/\/ror.org\/053pw6b94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systematic integration of circular RNA (circRNA)-disease associations is essential for elucidating the roles of circRNAs in disease pathogenesis and evaluating their potential as biomarkers and therapeutic targets. circRNADisease was established as a manually curated database of experimentally supported circRNA-disease associations. Here, we present circRNADisease v3.0, a substantially expanded and enhanced release containing 15\u2009390 curated circRNA-disease entries involving 9168 circRNAs, 656 MONDO-standardized disease terms, and 66 species, representing more than a twofold increase in data volume compared with v2.0. Each record is assigned a confidence score according to the strength and diversity of supporting evidence, including clinical evidence, circular-transcript identity verification, expression detection, functional experiments, molecular-mechanism validation, and bioinformatic analysis. The updated database also incorporates genomic coordinates, subcellular localization, experimental validation methods, clinical significance, data and code availability, and cross-references to multiple disease terminologies. Two new modules have been introduced. Circ2CNV contains 2\u2009962\u2009504 circRNA-cancer cohort records with copy-number variations across 33 TCGA cancer cohorts, whereas Circ2Celltype comprises 2025 cell-type-resolved evidence records covering 29 cell types. Together with the existing Circ2Mut module, these additions connect literature-curated circRNA-disease associations with genomic alterations and cellular contexts. circRNADisease v3.0 provides a comprehensive and evidence-oriented platform for circRNA research and is freely available at http:\/\/cgga.org.cn\/circRNADisease\/.<\/jats:p>","DOI":"10.1093\/nar\/gkag927","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:01:01Z","timestamp":1789473661000},"source":"Crossref","is-referenced-by-count":0,"title":["circRNADisease v3.0: an updated resource for high-quality, experimentally supported circRNA-disease associations"],"prefix":"10.1093","author":[{"given":"Chang-Lin","family":"Yang","sequence":"first","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Xiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-6351","authenticated-orcid":false,"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Chinese Glioma Genome Atlas (CGGA) Network and Asian Glioma Genome Atlas (AGGA) Network , Beijing 100070 ,","place":["China"]},{"name":"Chinese Neuro-Oncology Genome Atlas (CGGA-CNS) Network , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-9632","authenticated-orcid":false,"given":"Zheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Beijing Tiantan Hospital, Capital Medical University , Beijing 100070 ,","place":["China"]},{"name":"Chinese Glioma Genome Atlas (CGGA) Network and Asian Glioma Genome Atlas (AGGA) Network , Beijing 100070 ,","place":["China"]},{"name":"Chinese Neuro-Oncology Genome Atlas (CGGA-CNS) Network , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026092505200818900_B1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2026092505200818900_B2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026092505200818900_B3","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","article-title":"Circular RNAs: characterization, cellular roles, and applications","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"key":"2026092505200818900_B4","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1038\/s41467-022-30963-8","article-title":"Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing","volume":"13","author":"Wu","year":"2022","journal-title":"Nat Commun"},{"key":"2026092505200818900_B5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"2026092505200818900_B6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"2026092505200818900_B7","doi-asserted-by":"publisher","first-page":"6179","DOI":"10.7150\/ijbs.110146","article-title":"Circular RNA-encoded proteins in disease pathogenesis","volume":"21","author":"Uzoechina","year":"2025","journal-title":"Int J Biol Sci"},{"key":"2026092505200818900_B8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ncrna.2025.12.005","article-title":"The circular RNA landscape: biogenesis, functions, identification pipelines, and biomedical applications","volume":"18","author":"Baiddou","year":"2026","journal-title":"Noncoding RNA Res"},{"key":"2026092505200818900_B9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","article-title":"Circular RNA in cancer","volume":"24","author":"Conn","year":"2024","journal-title":"Nat Rev Cancer"},{"key":"2026092505200818900_B10","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","article-title":"The landscape of circular RNA in cancer","volume":"176","author":"Vo","year":"2019","journal-title":"Cell"},{"key":"2026092505200818900_B11","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41569-019-0185-2","article-title":"Circular RNAs open a new chapter in cardiovascular biology","volume":"16","author":"Aufiero","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2026092505200818900_B12","doi-asserted-by":"publisher","first-page":"101746","DOI":"10.1016\/j.pneurobio.2020.101746","article-title":"Role of circular RNAs in brain development and CNS diseases","volume":"186","author":"Mehta","year":"2020","journal-title":"Prog Neurobiol"},{"key":"2026092505200818900_B13","doi-asserted-by":"publisher","first-page":"e13220","DOI":"10.1111\/obr.13220","article-title":"Circular RNAs in metabolism and metabolic disorders","volume":"22","author":"Zeng","year":"2021","journal-title":"Obes Rev"},{"key":"2026092505200818900_B14","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.7150\/ijbs.22531","article-title":"Circular RNAs: a novel type of non-coding RNA and their potential implications in antiviral immunity","volume":"13","author":"Wang","year":"2017","journal-title":"Int J Biol Sci"},{"key":"2026092505200818900_B15","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41419-019-1744-5","article-title":"Roles of circular RNAs in immune regulation and autoimmune diseases","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis"},{"key":"2026092505200818900_B16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13046-017-0624-z","article-title":"Circular RNAs: emerging cancer biomarkers and targets","volume":"36","author":"Zhang","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"2026092505200818900_B17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.20517\/cdr.2024.195","article-title":"Circular RNAs modulate cancer drug resistance: advances and challenges","volume":"8","author":"Hua","year":"2025","journal-title":"Cancer Drug Resist"},{"key":"2026092505200818900_B18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12943-025-02254-5","article-title":"Role of circular RNAs in cancer therapy resistance","volume":"24","author":"Liu","year":"2025","journal-title":"Mol Cancer"},{"key":"2026092505200818900_B19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12943-024-02082-z","article-title":"Circular RNAs in tumor immunity and immunotherapy","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"2026092505200818900_B20","doi-asserted-by":"publisher","first-page":"11018","DOI":"10.1038\/s41598-018-29360-3","article-title":"Circ2Disease: a manually curated database of experimentally validated circRNAs in human disease","volume":"8","author":"Yao","year":"2018","journal-title":"Sci Rep"},{"key":"2026092505200818900_B21","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.gpb.2021.10.002","article-title":"CircR2Disease v2.0: an updated web server for experimentally validated circRNA\u2013disease associations and its application","volume":"20","author":"Fan","year":"2022","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2026092505200818900_B22","doi-asserted-by":"publisher","first-page":"D1365","DOI":"10.1093\/nar\/gkad828","article-title":"LncRNADisease v3.0: an updated database of long non-coding RNA-associated diseases","volume":"52","author":"Lin","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B23","doi-asserted-by":"publisher","first-page":"D1397","DOI":"10.1093\/nar\/gkac814","article-title":"RNADisease v4.0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction","volume":"51","author":"Chen","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B24","doi-asserted-by":"publisher","first-page":"D1251","DOI":"10.1093\/nar\/gkaa1006","article-title":"Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA\/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data","volume":"49","author":"Gao","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B25","doi-asserted-by":"publisher","first-page":"D83","DOI":"10.1093\/nar\/gkab809","article-title":"circMine: a comprehensive database to integrate, analyze and visualize human disease\u2013related circRNA transcriptome","volume":"50","author":"Zhang","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B26","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41419-018-0503-3","article-title":"circRNA disease: a manually curated database of experimentally supported circRNA-disease associations","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis"},{"key":"2026092505200818900_B27","doi-asserted-by":"publisher","first-page":"D1193","DOI":"10.1093\/nar\/gkad949","article-title":"circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations","volume":"52","author":"Sun","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B28","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1261\/rna.043687.113","article-title":"circBase: a database for circular RNAs","volume":"20","author":"Gla\u017ear","year":"2014","journal-title":"RNA"},{"key":"2026092505200818900_B29","doi-asserted-by":"publisher","first-page":"D1082","DOI":"10.1093\/nar\/gkad987","article-title":"The UCSC Genome Browser database: 2024 update","volume":"52","author":"Raney","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B30","doi-asserted-by":"publisher","first-page":"iyaf215","DOI":"10.1093\/genetics\/iyaf215","article-title":"Mondo: integrating disease terminology across communities","volume":"232","author":"Vasilevsky","year":"2026","journal-title":"Genetics"},{"key":"2026092505200818900_B31","doi-asserted-by":"publisher","first-page":"D1425","DOI":"10.1093\/nar\/gkaf1213","article-title":"The DO-KB knowledgebase 2026 update: expanding programmatic and language access","volume":"54","author":"Baron","year":"2026","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B32","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/cfg.445","article-title":"Overview and utilization of the NCI Thesaurus","volume":"5","author":"Fragoso","year":"2004","journal-title":"Comp Funct Genom"},{"key":"2026092505200818900_B33","doi-asserted-by":"publisher","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: online Mendelian Inheritance in Man (OMIM\u00ae), an online catalog of human genes and genetic disorders","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B34","doi-asserted-by":"publisher","first-page":"D1034","DOI":"10.1093\/nar\/gky905","article-title":"LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases","volume":"47","author":"Bao","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026092505200818900_B35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nbt.2203","article-title":"Absolute quantification of somatic DNA alterations in human cancer","volume":"30","author":"Carter","year":"2012","journal-title":"Nat Biotechnol"},{"key":"2026092505200818900_B36","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cell.2018.03.022","article-title":"Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer","volume":"173","author":"Hoadley","year":"2018","journal-title":"Cell"},{"key":"2026092505200818900_B37","doi-asserted-by":"publisher","first-page":"btac830","DOI":"10.1093\/bioinformatics\/btac830","article-title":"igv.js: an embeddable JavaScript implementation of the Integrative Genomics Viewer (IGV)","volume":"39","author":"Robinson","year":"2023","journal-title":"Bioinformatics"},{"key":"2026092505200818900_B38","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1161\/CIRCULATIONAHA.117.029004","article-title":"Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus","volume":"136","author":"Shan","year":"2017","journal-title":"Circulation"},{"key":"2026092505200818900_B39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13045-017-0422-2","article-title":"TTBK2 circular RNA promotes glioma malignancy by regulating miR-217\/HNF1\u03b2\/Derlin-1 pathway","volume":"10","author":"Zheng","year":"2017","journal-title":"J Hematol Oncol"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkag927\/71393725\/gkag927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkag927\/71393725\/gkag927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:31:23Z","timestamp":1790328683000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkag927\/8835508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag927","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"gkag927"}}