{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:55:59Z","timestamp":1790589359735,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Landes-Offensive zur Entwicklung Wissenschaftlich-\u00f6konomischer Exzellenz","award":["LOEWE\/1\/10\/519\/03\/03.001(0014)\/52"],"award-info":[{"award-number":["LOEWE\/1\/10\/519\/03\/03.001(0014)\/52"]}]},{"name":"LOEWE Centre for Translational Biodiversity Genomics","id":[{"id":"https:\/\/ror.org\/0396gab88","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SPP 2349"],"award-info":[{"award-number":["SPP 2349"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genomic Basis of Evolutionary Innovations"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Whole genome shotgun sequencing and assembly is routine. However, identifying protein-coding genes in newly assembled genomes remains complex, time-consuming, and labour-intensive. Therefore, most eukaryotic genome assemblies in public databases lack gene annotations reducing their value for evolutionary and functional genomics. Here, we present fDOG-Assembly (fDA), a novel tool for targeted, feature architecture-aware ortholog searches directly in unannotated genome assemblies. Benchmarking shows that fDA performs similarly to BUSCO and Compleasm in ortholog identification while offering the advantage of not being restricted to universal single-copy genes. Applied to identify orthologs of 5000 human genes in rat and Nematostella vectensis, fDA approaches the performance of traditional ortholog search tools that rely on pre-annotated proteomes. Importantly, it can recover orthologs missed by conventional methods because of incomplete gene annotations, helping to fill gaps in phylogenetic profiles. As a case study, we screened 176 soil invertebrate genome assemblies for genes involved in antibacterial compound production. We found that orthologs of \u03b2-lactam biosynthesis genes are widespread in springtails, with individual species possessing nearly complete cephamycin biosynthetic gene sets, suggesting they may represent previously unrecognized natural producers of \u03b2-lactam antibiotics. Overall, fDA is a powerful resource for orthology-based analyses of the rapidly growing collection of unannotated genome assemblies.<\/jats:p>","DOI":"10.1093\/nar\/gkag929","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:26:18Z","timestamp":1789673178000},"source":"Crossref","is-referenced-by-count":0,"title":["Targeted ortholog search in unannotated genome assemblies with fDOG-Assembly"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4651-8650","authenticated-orcid":false,"given":"Hannah","family":"Muelbaier","sequence":"first","affiliation":[{"name":"Applied Bioinformatics Group, Faculty of Biosciences, Goethe University Frankfurt , D-60438 Frankfurt am Main ,","place":["Germany"]},{"name":"LOEWE Centre for Translational Biodiversity Genomics (TBG) , D-60325 Frankfurt am Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Arthen","sequence":"additional","affiliation":[{"name":"Applied Bioinformatics Group, Faculty of Biosciences, Goethe University Frankfurt , D-60438 Frankfurt am Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinh","family":"Tran","sequence":"additional","affiliation":[{"name":"Applied Bioinformatics Group, Faculty of Biosciences, Goethe University Frankfurt , D-60438 Frankfurt am Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-4219","authenticated-orcid":false,"given":"Ina","family":"Schaefer","sequence":"additional","affiliation":[{"name":"LOEWE Centre for Translational Biodiversity Genomics (TBG) , D-60325 Frankfurt am Main ,","place":["Germany"]},{"name":"Senckenberg Biodiversity and Climate Research Centre (S-BIK-F) , D-60325 Frankfurt am Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"B\u00e1lint","sequence":"additional","affiliation":[{"name":"LOEWE Centre for Translational Biodiversity Genomics (TBG) , D-60325 Frankfurt am Main ,","place":["Germany"]},{"name":"Senckenberg Biodiversity and Climate Research Centre (S-BIK-F) , D-60325 Frankfurt am Main ,","place":["Germany"]},{"name":"Institute of Insect Biotechnology, Justus-Liebig University , 35392 Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-9253","authenticated-orcid":false,"given":"Ingo","family":"Ebersberger","sequence":"additional","affiliation":[{"name":"Applied Bioinformatics Group, Faculty of Biosciences, Goethe University Frankfurt , D-60438 Frankfurt am Main ,","place":["Germany"]},{"name":"LOEWE Centre for Translational Biodiversity Genomics (TBG) , D-60325 Frankfurt am Main ,","place":["Germany"]},{"name":"Senckenberg Biodiversity and Climate Research Centre (S-BIK-F) , D-60325 Frankfurt am Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026092805071101600_B1","doi-asserted-by":"publisher","first-page":"evae224","DOI":"10.1093\/gbe\/evae224","article-title":"Quest for orthologs in the era of biodiversity genomics","volume":"16","author":"Langschied","year":"2024","journal-title":"Genome Biol Evol"},{"key":"2026092805071101600_B2","first-page":"99","article-title":"Distinguishing homologous from analogous proteins","volume":"19","author":"Fitch","year":"1970","journal-title":"Syst Biol"},{"key":"2026092805071101600_B3","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nrg3456","article-title":"Functional and evolutionary implications of gene orthology","volume":"14","author":"Gabald\u00f3n","year":"2013","journal-title":"Nat Rev Genet"},{"key":"2026092805071101600_B4","doi-asserted-by":"publisher","first-page":"W623","DOI":"10.1093\/nar\/gkac330","article-title":"The Quest for Orthologs orthology benchmark service in 2022","volume":"50","author":"Nevers","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026092805071101600_B5","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1093\/bioinformatics\/btu492","article-title":"Big data and other challenges in the quest for orthologs","volume":"30","author":"Sonnhammer","year":"2014","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B6","doi-asserted-by":"publisher","first-page":"msaf120","DOI":"10.1093\/molbev\/msaf120","article-title":"Feature architecture-aware ortholog search with fDOG reveals the distribution of plant cell wall-degrading enzymes across life","volume":"42","author":"Tran","year":"2025","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B7","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1093\/bioinformatics\/btz859","article-title":"KofamKOALA: KEGG Ortholog assignment based on profile HMM and adaptive score threshold","volume":"36","author":"Aramaki","year":"2020","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B8","doi-asserted-by":"publisher","first-page":"5304","DOI":"10.1093\/bioinformatics\/btaa1051","article-title":"DeepNOG: fast and accurate protein orthologous group assignment","volume":"36","author":"Feldbauer","year":"2020","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B9","doi-asserted-by":"publisher","first-page":"D516","DOI":"10.1093\/nar\/gkae987","article-title":"OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes","volume":"53","author":"Tegenfeldt","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026092805071101600_B10","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1093\/bioinformatics\/btab219","article-title":"OMAmer: tree-driven and alignment-free protein assignment to subfamilies outperforms closest sequence approaches","volume":"37","author":"Rossier","year":"2021","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B11","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.3389\/fmicb.2021.739000","article-title":"Tracing eukaryotic ribosome biogenesis factors into the archaeal domain sheds light on the evolution of functional complexity","volume":"12","author":"Birikmen","year":"2021","journal-title":"Front Microbiol"},{"key":"2026092805071101600_B12","doi-asserted-by":"publisher","first-page":"e17351","DOI":"10.1111\/mec.17351","article-title":"Genomic evidence for the widespread presence of GH45 cellulases among soil invertebrates","volume":"33","author":"Muelbaier","year":"2024","journal-title":"Mol Ecol"},{"key":"2026092805071101600_B13","doi-asserted-by":"publisher","first-page":"btad226","DOI":"10.1093\/bioinformatics\/btad226","article-title":"FAS: assessing the similarity between proteins using multi-layered feature architectures","volume":"39","author":"Dosch","year":"2023","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B14","doi-asserted-by":"publisher","first-page":"e1010646","DOI":"10.1371\/journal.pgen.1010646","article-title":"Feature architecture aware phylogenetic profiling indicates a functional diversification of type IVa pili in the nosocomial pathogen Acinetobacter baumannii","volume":"19","author":"Iruegas","year":"2023","journal-title":"PLoS Genet"},{"key":"2026092805071101600_B15","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res"},{"key":"2026092805071101600_B16","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nrg.2016.119","article-title":"The state of play in higher eukaryote gene annotation","volume":"17","author":"Mudge","year":"2016","journal-title":"Nat Rev Genet"},{"key":"2026092805071101600_B17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12859-015-0515-2","article-title":"aTRAM - automated target restricted assembly method: a fast method for assembling loci across divergent taxa from next-generation sequencing data","volume":"16","author":"Allen","year":"2015","journal-title":"BMC Bioinf"},{"key":"2026092805071101600_B18","doi-asserted-by":"publisher","first-page":"apps.1600016","DOI":"10.3732\/apps.1600016","article-title":"HybPiper: extracting coding sequence and introns for phylogenetics from high-throughput sequencing reads using target enrichment1","volume":"4","author":"Johnson","year":"2016","journal-title":"Appl Plant Sci"},{"key":"2026092805071101600_B19","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1093\/bioinformatics\/btx078","article-title":"Kollector: transcript-informed, targeted de novo assembly of gene loci","volume":"33","author":"Kucuk","year":"2017","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B20","doi-asserted-by":"publisher","first-page":"1176934319874792","DOI":"10.1177\/1176934319874792","article-title":"Assexon: assembling exon using gene capture data","volume":"15","author":"Yuan","year":"2019","journal-title":"Evol Bioinform Online"},{"key":"2026092805071101600_B21","doi-asserted-by":"publisher","first-page":"e11019","DOI":"10.7717\/peerj.11019","article-title":"New alignment-based sequence extraction software (ALiBaSeq) and its utility for deep level phylogenetics","volume":"9","author":"Knyshov","year":"2021","journal-title":"PeerJ"},{"key":"2026092805071101600_B22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/1471-2148-9-157","article-title":"HaMStR: profile hidden markov model based search for orthologs in ESTs","volume":"9","author":"Ebersberger","year":"2009","journal-title":"BMC Evol Biol"},{"key":"2026092805071101600_B23","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1093\/molbev\/msab199","article-title":"BUSCO update: novel and streamlined workflows along with broader and deeper phylogenetic coverage for scoring of eukaryotic, prokaryotic, and viral genomes","volume":"38","author":"Manni","year":"2021","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12859-017-1529-8","article-title":"Orthograph: a versatile tool for mapping coding nucleotide sequences to clusters of orthologous genes","volume":"18","author":"Petersen","year":"2017","journal-title":"BMC Bioinf"},{"key":"2026092805071101600_B25","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.cub.2017.02.031","article-title":"A large and consistent phylogenomic dataset supports sponges as the sister group to all other animals","volume":"27","author":"Simion","year":"2017","journal-title":"Curr Biol"},{"key":"2026092805071101600_B26","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/molbev\/msr285","article-title":"A consistent phylogenetic backbone for the fungi","volume":"29","author":"Ebersberger","year":"2012","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B27","doi-asserted-by":"publisher","first-page":"eabn3107","DOI":"10.1126\/science.abn3107","article-title":"Integrating gene annotation with orthology inference at scale","volume":"380","author":"Kirilenko","year":"2023","journal-title":"Science"},{"key":"2026092805071101600_B28","doi-asserted-by":"publisher","first-page":"5825","DOI":"10.1093\/molbev\/msab293","article-title":"eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale","volume":"38","author":"Cantalapiedra","year":"2021","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B29","doi-asserted-by":"publisher","first-page":"btad595","DOI":"10.1093\/bioinformatics\/btad595","article-title":"compleasm: a faster and more accurate reimplementation of BUSCO","volume":"39","author":"Huang","year":"2023","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41597-024-03571-y","article-title":"Exploring and retrieving sequence and metadata for species across the tree of life with NCBI Datasets","volume":"11","author":"O\u2019Leary","year":"2024","journal-title":"Sci Data"},{"key":"2026092805071101600_B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-023-05621-4","article-title":"The MetaInvert soil invertebrate genome resource provides insights into below-ground biodiversity and evolution","volume":"6","author":"Collins","year":"2023","journal-title":"Commun Biol"},{"key":"2026092805071101600_B32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"2026092805071101600_B33","doi-asserted-by":"publisher","first-page":"btad014","DOI":"10.1093\/bioinformatics\/btad014","article-title":"Protein-to-genome alignment with miniprot","volume":"39","author":"Li","year":"2023","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B34","doi-asserted-by":"publisher","first-page":"e57","DOI":"10.1002\/cpbi.57","article-title":"Predicting Genes in Single Genomes with AUGUSTUS","volume":"65","author":"Hoff","year":"2019","journal-title":"Curr Protoc Bioinformatics"},{"key":"2026092805071101600_B35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40168-020-00808-x","article-title":"MetaEuk\u2014sensitive, high-throughput gene discovery, and annotation for large-scale eukaryotic metagenomics","volume":"8","author":"Levy\u00a0Karin","year":"2020","journal-title":"Microbiome"},{"key":"2026092805071101600_B36","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.1128\/JB.180.16.4068-4079.1998","article-title":"Investigation of the Streptomyces clavuligerus Cephamycin C gene cluster and its regulation by the CcaR protein","volume":"180","author":"Alexander","year":"1998","journal-title":"J Bacteriol"},{"key":"2026092805071101600_B37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1001861025070","article-title":"Gene organization and plasticity of the \u03b2-lactam genes in different filamentous fungi","volume":"75","author":"Guti\u00e9rrez","year":"1999","journal-title":"Antonie Van Leeuwenhoek"},{"key":"2026092805071101600_B38","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1093\/bioinformatics\/bty225","article-title":"PhyloProfile: dynamic visualization and exploration of multi-layered phylogenetic profiles","volume":"34","author":"Tran","year":"2018","journal-title":"Bioinformatics"},{"key":"2026092805071101600_B39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat Methods"},{"key":"2026092805071101600_B40","doi-asserted-by":"publisher","first-page":"6968","DOI":"10.1038\/s41467-022-34630-w","article-title":"Muscle5: high-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny","volume":"13","author":"Edgar","year":"2022","journal-title":"Nat Commun"},{"key":"2026092805071101600_B41","doi-asserted-by":"publisher","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated Profile HMM Searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"2026092805071101600_B42","doi-asserted-by":"publisher","first-page":"lqae167","DOI":"10.1093\/nargab\/lqae167","article-title":"New developments for the quest for orthologs benchmark service","volume":"6","author":"Altenhoff","year":"2024","journal-title":"NAR Genomics Bioinforma"},{"key":"2026092805071101600_B43","doi-asserted-by":"publisher","first-page":"W538","DOI":"10.1093\/nar\/gkaa308","article-title":"The Quest for Orthologs benchmark service and consensus calls in 2020","volume":"48","author":"Altenhoff","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026092805071101600_B44","doi-asserted-by":"publisher","first-page":"msac174","DOI":"10.1093\/molbev\/msac174","article-title":"TimeTree 5: an expanded resource for species divergence times","volume":"39","author":"Kumar","year":"2022","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B45","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/gbe\/evz008","article-title":"The evolutionary traceability of a protein","volume":"11","author":"Jain","year":"2019","journal-title":"Genome Biol Evol"},{"key":"2026092805071101600_B46","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1039\/C2NP20065A","article-title":"The enzymes of \u03b2-lactam biosynthesis","volume":"30","author":"Hamed","year":"2013","journal-title":"Nat Prod Rep"},{"key":"2026092805071101600_B47","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1111\/mec.14109","article-title":"Evolutionary ecology of beta-lactam gene clusters in animals","volume":"26","author":"Suring","year":"2017","journal-title":"Mol Ecol"},{"key":"2026092805071101600_B48","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/jhered\/est050","article-title":"The i5K Initiative: advancing arthropod genomics for knowledge, human health, agriculture, and the environment","volume":"104","author":"i5K Consortium","year":"2013","journal-title":"J Hered"},{"key":"2026092805071101600_B49","doi-asserted-by":"publisher","first-page":"e2115635118","DOI":"10.1073\/pnas.2115635118","article-title":"The Earth BioGenome Project 2020: starting the clock","volume":"119","author":"Lewin","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026092805071101600_B50","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-animal-022516-022811","article-title":"Bat Biology, Genomes, and the Bat1K Project: to Generate Chromosome-Level Genomes for All Living Bat Species","volume":"6","author":"Teeling","year":"2018","journal-title":"Annu Rev Anim Biosci"},{"key":"2026092805071101600_B51","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinf"},{"key":"2026092805071101600_B52","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3390\/insects14030215","article-title":"Diversity of the antimicrobial peptide genes in Collembola","volume":"14","author":"Pradhan","year":"2023","journal-title":"Insects"},{"key":"2026092805071101600_B53","first-page":"1","article-title":"New aspects of genes and enzymes for \u03b2-lactam antibiotic biosynthesis","volume":"50","author":"Mart\u00edn","year":"1998","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026092805071101600_B54","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1093\/molbev\/mss269","article-title":"A functional isopenicillin N synthase in an animal genome","volume":"30","author":"Roelofs","year":"2013","journal-title":"Mol Biol Evol"},{"key":"2026092805071101600_B55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/21505594.2018.1558693","article-title":"The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii","volume":"10","author":"Weidensdorfer","year":"2019","journal-title":"Virulence"},{"key":"2026092805071101600_B56","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/jam.13899","article-title":"Antimicrobial activity in culturable gut microbial communities of springtails","volume":"125","author":"Agamennone","year":"2018","journal-title":"J Appl Microbiol"},{"key":"2026092805071101600_B57","doi-asserted-by":"publisher","first-page":"e01972","DOI":"10.1128\/mBio.01972-14","article-title":"Origin in Acinetobacter guillouiae and dissemination of the aminoglycoside-modifying enzyme Aph(3\u2032)-VI","volume":"5","author":"Yoon","year":"2014","journal-title":"mBio"},{"key":"2026092805071101600_B58","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fmicb.2019.00460","article-title":"Discovery of novel antibiotic resistance determinants in forest and grassland soil metagenomes","volume":"10","author":"Willms","year":"2019","journal-title":"Front Microbiol"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/18\/gkag929\/71431681\/gkag929.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/18\/gkag929\/71431681\/gkag929.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:07:39Z","timestamp":1790586459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkag929\/8840865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":58,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkag929","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10,14]]},"published":{"date-parts":[[2026,9,22]]},"article-number":"gkag929"}}