{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:35Z","timestamp":1792786055501,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERDF\/EU"},{"name":"Programa de Ayudas a la I+D+ i, en R\u00e9gimen de Concurrencia Competitiva en el \u00c1mbito del Plan Andaluz de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","award":["PAIDI 2020"],"award-info":[{"award-number":["PAIDI 2020"]}]},{"name":"Scientific Exchange Grants"},{"name":"University of Sevilla","id":[{"id":"https:\/\/ror.org\/03yxnpp24","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CBUA\u2014University of Seville","id":[{"id":"https:\/\/ror.org\/03yxnpp24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cellular quiescence is a low metabolic, non-proliferative state critical for tissue maintenance and regenerative capacity, with broad implications for aging and age-related diseases. In Caenorhabditis elegans, L1 developmental arrest upon hatching in the absence of food provides a robust in vivo model to study quiescence. Here, we investigate the roles of the transcription factors HLH-30\/TFEB and DAF-16\/FOXO during L1 arrest. We show that HLH-30 and DAF-16 collaborate to ensure survival under starvation, with reciprocal regulation of their subcellular localization and transcriptional activity. HLH-30 exerts broad transcriptional control during L1 arrest, modulating genes involved in chromosome organization and cell cycle progression. Profiling of chromatin spatial distribution reveals that HLH-30 is required for fasting-induced 3D chromatin reorganization. Loss of HLH-30 disrupts seam cell cycle arrest and causes the overactivation of the transcription factors BLMP-1 and CEBP-1, which contribute to premature initiation of developmental programs under starvation. Our findings uncover previously unrecognized functions of HLH-30 in genome architecture and quiescence regulation, highlighting conserved mechanisms of transcriptional control during nutrient deprivation with implications for aging and disease.<\/jats:p>","DOI":"10.1093\/nar\/gkag949","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:12:47Z","timestamp":1789989167000},"source":"Crossref","is-referenced-by-count":0,"title":["HLH-30\/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in\n                    <i>C.\u00a0elegans<\/i>"],"prefix":"10.1093","volume":"54","author":[{"given":"Marta","family":"Mu\u00f1oz-Barrera","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-2746","authenticated-orcid":false,"given":"Alejandro","family":"Mata-Cabana","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Moreno-Rivero","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5297","authenticated-orcid":false,"given":"Francine A","family":"Piubeli","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6817-7616","authenticated-orcid":false,"given":"Beatriz","family":"Ren-Barroso","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Al-Refaie","sequence":"additional","affiliation":[{"name":"Institute of Functional Epigenetics, Helmholtz Zentrum Muenchen , Neuherberg D-85764 ,","place":["Germany"]},{"name":"Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t Muenchen , Munich D-80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Biolog\u00eda, Universidad de Sevilla , Seville 41012 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