{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:55:20Z","timestamp":1791194120530,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD110990"],"award-info":[{"award-number":["R01 HD110990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM148028"],"award-info":[{"award-number":["R01 GM148028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 GM149376-01"],"award-info":[{"award-number":["P30 GM149376-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM148028"],"award-info":[{"award-number":["R01 GM148028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD098129"],"award-info":[{"award-number":["R01 HD098129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"CPRIT","doi-asserted-by":"publisher","award":["R1213"],"award-info":[{"award-number":["R1213"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"CPRIT","doi-asserted-by":"publisher","award":["RP170628"],"award-info":[{"award-number":["RP170628"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cockrell Endowment","id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH-NICHD"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Proper segregation of meiotic chromosomes depends on the controlled formation and resolution of recombination intermediates that give rise to crossovers (COs). While the BTRR complex\u2014comprising the BLM helicase, topoisomerase III\u03b1, and the proteins RMI1 and RMI2\u2014is a well-characterized regulator of recombination in somatic cells, its function during meiosis remains incompletely understood, particularly for RMI2 in mammals. Here, we investigate the role of RMI2 in mouse spermatogenesis using a targeted RMI2 knockout model. Loss of RMI2 results in severe meiotic defects, including reduced testis size, increased apoptosis at the metaphase\u2013anaphase I transition, and frequent chromosomal abnormalities such as lagging chromosomes in metaphase I cells and anaphase I chromatin bridges. Cytological analyses reveal disruptions in the processing of recombination intermediates. Our work monitoring molecular recombination outcomes at known recombination hotspots suggests that RMI2 regulates the balance of recombination pathways, constrains aberrant branch migration, and ensures proper CO maturation. Our findings show previously unappreciated functions for RMI2 essential for coordinating recombination intermediate metabolism and promoting proper chromosome conformation and segregation during meiosis. These results provide insights into the complex regulation of recombination intermediate homeostasis in higher eukaryotes and highlight the role of RMI2 in maintaining genome stability and proper gamete development in mammals.<\/jats:p>","DOI":"10.1093\/nar\/gkag950","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:23:12Z","timestamp":1791192192000},"source":"Crossref","is-referenced-by-count":0,"title":["RMI2 regulates recombination intermediate metabolism to ensure proper chromosome segregation in mammalian meiosis"],"prefix":"10.1093","volume":"54","author":[{"given":"Luciana Previato","family":"de\u00a0Almeida","sequence":"first","affiliation":[{"name":"Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolkappiyan","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 ,","place":["United States"]},{"name":"UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3012-2601","authenticated-orcid":false,"given":"Monika K","family":"Kawecka","sequence":"additional","affiliation":[{"name":"Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104 ,","place":["United States"]},{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Gryniuk","sequence":"additional","affiliation":[{"name":"Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104 ,","place":["United States"]},{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Carbajal","sequence":"additional","affiliation":[{"name":"Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-2363","authenticated-orcid":false,"given":"Francesca","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 ,","place":["United States"]},{"name":"UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-5516","authenticated-orcid":false,"given":"Roberto J","family":"Pezza","sequence":"additional","affiliation":[{"name":"Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104 ,","place":["United States"]},{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026100505230483900_B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-genet-061323-044915","article-title":"Meiosis: dances between homologs","volume":"57","author":"Zickler","year":"2023","journal-title":"Annu Rev Genet"},{"key":"2026100505230483900_B2","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1111\/febs.13317","article-title":"Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination","volume":"282","author":"Sansam","year":"2015","journal-title":"FEBS J"},{"key":"2026100505230483900_B3","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev 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