{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:51:59Z","timestamp":1791363119477,"version":"4.3.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA252707"],"award-info":[{"award-number":["CA252707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM157928"],"award-info":[{"award-number":["GM157928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG067664"],"award-info":[{"award-number":["AG067664"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA279317"],"award-info":[{"award-number":["CA279317"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA255506"],"award-info":[{"award-number":["CA255506"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de recherche du Qu\u00e9bec PhD scholar","id":[{"id":"https:\/\/ror.org\/00w3qhf76","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eleven-nineteen-leukemia (ENL) is a well-established epigenetic regulator essential for transcription in development and implicated in cancer. Here, we report the molecular mechanisms and functional consequences of the ENL association with components of transcriptional and chromatin remodeling complexes, TAF2, TAF6, and SNF5, and describe ENL intramolecular contacts and autoregulation. We show that the extra-terminal domain of ENL binds in an acetylation-independent manner to the hydrophobic motifs identified in intrinsically disordered regions of TAF2, TAF6, and SNF5. Genomic analysis reveals genome-wide co-occupancy of ENL and TAF2 or SNF5 on active promoters, and proteomic and transcriptomic analyses demonstrate increased tumor-associated correlations of ENL with TAF2, TAF6, and SNF5 and their coordinated co-expression patterns in several types of cancer. Our findings shed light on the mechanistic details by which ENL associates with chromatin cofactors and is autoregulated, paving the way for the development of novel ENL targeted antitumor interventions.<\/jats:p>","DOI":"10.1093\/nar\/gkag959","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:17:05Z","timestamp":1790335025000},"source":"Crossref","is-referenced-by-count":0,"title":["Acetylation-independent mechanism for binding of ENL to intrinsically disordered regions in TAF2\/6 and SNF5"],"prefix":"10.1093","volume":"54","author":[{"given":"Zohreh","family":"Tavaf","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Colorado School of Medicine , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Khalil","sequence":"additional","affiliation":[{"name":"Cell Signaling and Cancer Research Unit, Maisonneuve-Rosemont Hospital Research Center , CIUSSS de l\u2019Est-de-l\u2019\u00eele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Chau","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Colorado School of Medicine , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Epigenetics, Van Andel Institute , Grand Rapids, MI 49503 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddha J","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92127 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00a0Bachir","family":"Affar","sequence":"additional","affiliation":[{"name":"Cell Signaling and Cancer Research Unit, Maisonneuve-Rosemont Hospital Research Center , CIUSSS de l\u2019Est-de-l\u2019\u00eele de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4 ,","place":["Canada"]},{"name":"Department of Medicine, University of Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec H3C 3J7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Andres","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine , Philadelphia, PA 19104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana G","family":"Kutateladze","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Colorado School of Medicine , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026100704144244200_B1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/0092-8674(92)90602-9","article-title":"Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias","volume":"71","author":"Tkachuk","year":"1992","journal-title":"Cell"},{"key":"2026100704144244200_B2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ccr.2009.12.040","article-title":"A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription","volume":"17","author":"Yokoyama","year":"2010","journal-title":"Cancer Cell"},{"key":"2026100704144244200_B3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.exphem.2010.09.003","article-title":"MLL-AF9 and MLL-ENL alter the dynamic 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