{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:06:49Z","timestamp":1792656409792,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":2704,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1093\/nar\/gkp1149","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T21:20:26Z","timestamp":1260825626000},"page":"1489-1503","source":"Crossref","is-referenced-by-count":57,"title":["CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response"],"prefix":"10.1093","volume":"38","author":[{"given":"Olivier J.","family":"Becherel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Gueven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Fusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda W.","family":"Kijas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Katyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Epe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Smerdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Taucher-Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Lavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"key\n\t\t\t\t20170510133950_B1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng1001-189","article-title":"The gene mutated in ataxia-ocular apraxia type 1 encodes the new HIT\/Zn-finger protein aprataxin","volume":"29","author":"Moreira","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510133950_B2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng1001-184","article-title":"Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene","volume":"29","author":"Date","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510133950_B3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.410240404","article-title":"Ataxia-ocular motor apraxia: asyndrome mimicking ataxia-telangiectasia","volume":"4","author":"Aicardi","year":"1988","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170510133950_B4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.immunol.15.1.177","article-title":"The genetic defect in ataxia-telangiectasia","volume":"15","author":"Lavin","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"key\n\t\t\t\t20170510133950_B5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4161\/cc.6.8.4180","article-title":"ATM activation and DNA damage response","volume":"6","author":"Lavin","year":"2007","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170510133950_B6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0092-8674(02)01247-3","article-title":"DNA single-strand break repair and spinocerebellar ataxia","volume":"112","author":"Caldecott","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1097-4652(199911)181:2<179::AID-JCP1>3.0.CO;2-8","article-title":"The histidine triad superfamily of nucleotide-binding proteins","volume":"181","author":"Brenner","year":"1999","journal-title":"J. Cell Physiol."},{"key":"key\n\t\t\t\t20170510133950_B8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/hmg\/ddh122","article-title":"Aprataxin, a novel protein that protects against genotoxic stress","volume":"13","author":"Gueven","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170510133950_B9","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.dnarep.2004.06.017","article-title":"The ataxia-oculomotor apraxia type 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4","volume":"3","author":"Clements","year":"2004","journal-title":"DNA Repair"},{"key":"key\n\t\t\t\t20170510133950_B10","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1128\/MCB.24.19.8356-8365.2004","article-title":"A new XRCC1-containing complex and its role in cellular survival of methyl methane sulfonate treatment","volume":"24","author":"Luo","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510133950_B11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00018-004-4441-0","article-title":"The novel human gene aprataxin is directly involved in DNA single-strand break repair","volume":"62","author":"Mosesso","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t20170510133950_B12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ana.21078","article-title":"DNA single-strand break repair is impaired in aprataxin-related ataxia","volume":"61","author":"Hirano","year":"2007","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170510133950_B13","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.neuroscience.2006.12.010","article-title":"A subgroup of spinocerebellar ataxias defective in DNA damage responses","volume":"145","author":"Gueven","year":"2007","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170510133950_B14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nature05164","article-title":"The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates","volume":"443","author":"Ahel","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510133950_B15","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1074\/jbc.M611489200","article-title":"Actions of aprataxin in multiple DNA repair pathways","volume":"282","author":"Rass","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1126\/science.186.4166.790","article-title":"DNA ligase: structure, mechanism, and function","volume":"186","author":"Lehman","year":"1974","journal-title":"Science"},{"key":"key\n\t\t\t\t20170510133950_B17","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1093\/hmg\/ddp359","article-title":"Aprataxin combines with Poly-ADP Ribose Polymerase 1 (PARP-1) and Apurinic Endonuclease 1 (APE1) to protect the genome against oxidative damage","volume":"18","author":"Harris","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170510133950_B18","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1074\/jbc.M507946200","article-title":"Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA\/RNA binding and nucleotide hydrolase activities","volume":"281","author":"Kijas","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B19","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.dnarep.2009.02.002","article-title":"Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin","volume":"8","author":"El-Khamisy","year":"2009","journal-title":"DNA Repair"},{"key":"key\n\t\t\t\t20170510133950_B20","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0960-9822(00)00610-2","article-title":"A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage","volume":"10","author":"Paull","year":"2000","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170510133950_B21","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.153.3.613","article-title":"Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways","volume":"153","author":"Rappold","year":"2001","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170510133950_B22","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B23","doi-asserted-by":"crossref","first-page":"32635","DOI":"10.1074\/jbc.M004085200","article-title":"Cellular responses and repair of single-strand breaks introduced by UV damage endonuclease in mammalian cells","volume":"275","author":"Okano","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2307\/3578455","article-title":"A new method for introducing double-strand breaks into cellular DNA","volume":"134","author":"Limoli","year":"1993","journal-title":"Radiat. Res."},{"key":"key\n\t\t\t\t20170510133950_B25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1046\/j.0022-202x.2001.01540.x","article-title":"In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts","volume":"117","author":"Katsumi","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170510133950_B26","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/sj.emboj.7600269","article-title":"Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention","volume":"23","author":"Lukas","year":"2004","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510133950_B27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1667\/0033-7587(2003)159[0676:BIOHCT]2.0.CO;2","article-title":"Biological imaging of heavy charged-particle tracks","volume":"159","author":"Jakob","year":"2003","journal-title":"Radiat. Res."},{"key":"key\n\t\t\t\t20170510133950_B28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1667\/RR3374","article-title":"Live cell imaging of heavy-ion-induced radiation responses by beamline microscopy","volume":"163","author":"Jakob","year":"2005","journal-title":"Radiat. Res."},{"key":"key\n\t\t\t\t20170510133950_B29","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature01446","article-title":"MDC1 is a mediator of the mammalian DNA damage checkpoint","volume":"421","author":"Stewart","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510133950_B30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nature01445","article-title":"MDC1 is required for the intra-S-phase DNA damage checkpoint","volume":"421","author":"Goldberg","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510133950_B31","doi-asserted-by":"crossref","first-page":"13599","DOI":"10.1074\/jbc.C300060200","article-title":"Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control","volume":"278","author":"Lou","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B32","doi-asserted-by":"crossref","first-page":"46359","DOI":"10.1074\/jbc.C400375200","article-title":"MDC1 regulates DNA-PK autophosphorylation in response to DNA damage","volume":"279","author":"Lou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature01447","article-title":"MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways","volume":"421","author":"Lou","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510133950_B34","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2005.09.038","article-title":"MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks","volume":"123","author":"Stucki","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B35","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1073\/pnas.0802885105","article-title":"MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks","volume":"105","author":"Wu","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510133950_B36","doi-asserted-by":"crossref","first-page":"re12","DOI":"10.1126\/scisignal.151re12","article-title":"Structure and function of the phosphothreonine-specific FHA domain","volume":"1","author":"Mahajan","year":"2008","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20170510133950_B37","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/hmg\/ddl149","article-title":"Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription","volume":"15","author":"Becherel","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170510133950_B38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170510133950_B39","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"Collaborative Computational Project, Number 4. The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr. D. Biol. Crystallogr"},{"key":"key\n\t\t\t\t20170510133950_B40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0076-6879(97)76079-8","article-title":"AMoRe: an automated molecular replacement program package","volume":"276","author":"Navaza","year":"1997","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170510133950_B41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"key\n\t\t\t\t20170510133950_B42","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"key\n\t\t\t\t20170510133950_B43","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1083\/jcb.200701042","article-title":"Senataxin defective in ataxia oculomotor apraxia type 2 is involved in the defence against oxidative DNA damage","volume":"177","author":"Suraweera","year":"2007","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170510133950_B44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0076-6879(94)34083-8","article-title":"Oxidative DNA damage: endonuclease fingerprinting","volume":"234","author":"Epe","year":"1994","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170510133950_B45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/09553009414551401","article-title":"The complexity of DNA damage: relevance to biological consequences","volume":"66","author":"Ward","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"key\n\t\t\t\t20170510133950_B46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1667\/RR1520.1","article-title":"Positional stability of damaged chromatin domains along radiation tracks in mammalian cells","volume":"171","author":"Jakob","year":"2009","journal-title":"Radiat. Res."},{"key":"key\n\t\t\t\t20170510133950_B47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1097-2765(00)80340-8","article-title":"The FHA domain is a modular phosphopeptide recognition motif","volume":"4","author":"Durocher","year":"1999","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170510133950_B48","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S1097-2765(00)00114-3","article-title":"The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms","volume":"6","author":"Durocher","year":"2000","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170510133950_B49","doi-asserted-by":"crossref","first-page":"12130","DOI":"10.1073\/pnas.0404720101","article-title":"Large-scale characterization of HeLa cell nuclear phosphoproteins","volume":"101","author":"Beausoleil","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510133950_B50","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2006.09.026","article-title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks","volume":"127","author":"Olsen","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1083\/jcb.200708210","article-title":"Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin","volume":"181","author":"Melander","year":"2008","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170510133950_B52","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/embor.2008.103","article-title":"Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage","volume":"9","author":"Chapman","year":"2008","journal-title":"EMBO Rep."},{"key":"key\n\t\t\t\t20170510133950_B53","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1038\/sj.emboj.7600375","article-title":"Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV","volume":"23","author":"Koch","year":"2004","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510133950_B54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200709008","article-title":"Constitutive phosphorylation of MDC1 physically links the MRE11\u2013RAD50\u2013NBS1 complex to damaged chromatin","volume":"181","author":"Spycher","year":"2008","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170510133950_B55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.molcel.2005.02.012","article-title":"The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase","volume":"17","author":"Bernstein","year":"2005","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170510133950_B56","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molcel.2005.11.025","article-title":"MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals","volume":"21","author":"Lou","year":"2006","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170510133950_B57","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/MCB.01471-08","article-title":"Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1","volume":"29","author":"Reynolds","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510133950_B58","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cell.2007.09.041","article-title":"RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly","volume":"131","author":"Huen","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2007.09.040","article-title":"RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins","volume":"131","author":"Mailand","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B60","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1126\/science.1150034","article-title":"Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase","volume":"318","author":"Kolas","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170510133950_B61","doi-asserted-by":"crossref","first-page":"13549","DOI":"10.1074\/jbc.M710197200","article-title":"RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage","volume":"283","author":"Sakasai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B62","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1074\/jbc.M807375200","article-title":"The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage","volume":"284","author":"Eliezer","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B63","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2008.12.041","article-title":"RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins","volume":"136","author":"Doil","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B64","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cell.2008.12.042","article-title":"The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage","volume":"136","author":"Stewart","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B65","doi-asserted-by":"crossref","first-page":"32053","DOI":"10.1074\/jbc.M705890200","article-title":"The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex\/cyclosome","volume":"282","author":"Coster","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510133950_B66","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nsmb991","article-title":"MDC1 interacts with Rad51 and facilitates homologous recombination","volume":"12","author":"Zhang","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20170510133950_B67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(04)00206-5","article-title":"The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks","volume":"117","author":"Loizou","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510133950_B68","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.200510130","article-title":"Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks","volume":"173","author":"Bekker-Jensen","year":"2006","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170510133950_B69","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1667\/RR1165.1","article-title":"Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts","volume":"169","author":"Asaithamby","year":"2008","journal-title":"Radiat. Res."},{"key":"key\n\t\t\t\t20170510133950_B70","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4161\/cc.2.5.483","article-title":"Cell cycle-regulated centers of DNA double-strand break repair","volume":"2","author":"Lisby","year":"2003","journal-title":"Cell Cycle"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/38\/5\/1489\/16770590\/gkp1149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T10:40:38Z","timestamp":1522665638000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkp1149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,14]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,12,14]]},"published-print":{"date-parts":[[2010,3]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkp1149","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,14]]}}}