{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:30:51Z","timestamp":1791415851178,"version":"4.3.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":2332,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1093\/nar\/gkq527","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T20:24:32Z","timestamp":1277151872000},"page":"6577-6588","source":"Crossref","is-referenced-by-count":36,"title":["Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription"],"prefix":"10.1093","volume":"38","author":[{"given":"Christoph","family":"Freyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Bae","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats I.","family":"Ekstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Khvorostova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Wibom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Falkenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes M.","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils-G\u00f6ran","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,6,20]]},"reference":[{"key":"key\n\t\t\t\t20170510130725_B1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-biochem-060408-093701","article-title":"Somatic mitochondrial DNA mutations in mammalian aging","author":"Larsson","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170510130725_B2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2007.01905.x","article-title":"Mitochondrial dysfunction as a cause of ageing","volume":"263","author":"Trifunovic","year":"2008","journal-title":"J. Intern. Med."},{"key":"key\n\t\t\t\t20170510130725_B3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1146\/annurev.biochem.76.060305.152028","article-title":"DNA replication and transcription in mammalian mitochondria","volume":"76","author":"Falkenberg","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170510130725_B4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng909","article-title":"Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA","volume":"31","author":"Falkenberg","year":"2002","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130725_B5","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.C110.128918","article-title":"Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro","author":"Litonin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510130725_B6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2009.10.031","article-title":"TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase","volume":"139","author":"Sologub","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510130725_B7","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1038\/sj.emboj.7600465","article-title":"The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells","volume":"23","author":"Gaspari","year":"2004","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170510130725_B8","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/MCB.13.3.1951","article-title":"A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro","volume":"13","author":"Parisi","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170510130725_B9","doi-asserted-by":"crossref","first-page":"31149","DOI":"10.1074\/jbc.M303842200","article-title":"Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40","volume":"278","author":"Matsushima","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510130725_B10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/hmg\/ddh109","article-title":"Mitochondrial transcription factor A regulates mtDNA copy number in mammals","volume":"13","author":"Ekstrand","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170510130725_B11","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/nar\/gkg251","article-title":"Human mitochondrial DNA is packaged with TFAM","volume":"31","author":"Alam","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510130725_B12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/embo-reports\/kvf099","article-title":"Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein","volume":"3","author":"Takamatsu","year":"2002","journal-title":"EMBO Rep."},{"key":"key\n\t\t\t\t20170510130725_B13","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1016\/S0021-9258(19)50739-6","article-title":"DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein","volume":"267","author":"Fisher","year":"1992","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510130725_B14","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1091\/mbc.E07-05-0404","article-title":"The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures","volume":"18","author":"Kaufman","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"key\n\t\t\t\t20170510130725_B15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/jmbi.1995.9889","article-title":"Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator","volume":"249","author":"Dairaghi","year":"1995","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170510130725_B16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ng0398-231","article-title":"Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice","volume":"18","author":"Larsson","year":"1998","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130725_B17","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1073\/pnas.0308710100","article-title":"A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts","volume":"101","author":"Hansson","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510130725_B18","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1073\/pnas.97.7.3467","article-title":"Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510130725_B19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/5089","article-title":"Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression","volume":"21","author":"Wang","year":"1999","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130725_B20","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1046-2023(02)00034-8","article-title":"Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells","volume":"26","author":"Fern\u00e1ndez-Vizarra","year":"2002","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170510130725_B21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0003-2697(02)00424-4","article-title":"Measurement of ATP production and respiratory chain enzyme activities in mitochondria isolated from small muscle biopsy samples","volume":"311","author":"Wibom","year":"2002","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170510130725_B22","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1073\/pnas.232591499","article-title":"Increased mitochondrial mass in mitochondrial myopathy mice","volume":"99","author":"Wredenberg","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510130725_B23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0076-6879(96)64008-7","article-title":"In organello RNA synthesis system from mammalian liver and brain","volume":"264","author":"Enriquez","year":"1996","journal-title":"Meth. Enzymol."},{"key":"key\n\t\t\t\t20170510130725_B24","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cmet.2009.03.001","article-title":"Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome","volume":"9","author":"Metodiev","year":"2009","journal-title":"Cell Metab."},{"key":"key\n\t\t\t\t20170510130725_B25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2007.05.046","article-title":"MTERF3 is a negative regulator of mammalian mtDNA transcription","volume":"130","author":"Park","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510130725_B26","doi-asserted-by":"crossref","first-page":"36743","DOI":"10.1074\/jbc.M806174200","article-title":"Native R-loops persist throughout the mouse mitochondrial DNA genome","volume":"283","author":"Brown","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170510130725_B27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tem.2005.10.007","article-title":"The endocrine function of the heart","volume":"16","author":"McGrath","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"key":"key\n\t\t\t\t20170510130725_B28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1474-9726.2007.00319.x","article-title":"Transcriptional response to aging and caloric restriction in heart and adipose tissue","volume":"6","author":"Linford","year":"2007","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20170510130725_B29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng1291","article-title":"Comparing genomic expression patterns across species identifies shared transcriptional profile in aging","volume":"36","author":"McCarroll","year":"2004","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170510130725_B30","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pgen.0020115","article-title":"Transcriptional profiling of aging in human muscle reveals a common aging signature","volume":"2","author":"Zahn","year":"2006","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170510130725_B31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.copbio.2007.07.004","article-title":"Systems biology of aging in four species","volume":"18","author":"Zahn","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"key\n\t\t\t\t20170510130725_B32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1006\/bbrc.1998.9703","article-title":"Reduced mitochondrial DNA transcription in senescent rat heart","volume":"252","author":"Andreu","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170510130725_B33","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.biochi.2007.03.018","article-title":"Aging impact on biochemical activities and gene expression of Drosophila melanogaster mitochondria","volume":"89","author":"Dubessay","year":"2007","journal-title":"Biochimie."},{"key":"key\n\t\t\t\t20170510130725_B34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1432-1033.1990.tb15331.x","article-title":"Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine","volume":"187","author":"Gadaleta","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20170510130725_B35","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1523\/JNEUROSCI.21-20-08082.2001","article-title":"Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice","volume":"21","author":"S\u00f6rensen","year":"2001","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170510130725_B36","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1073\/pnas.68.8.1757","article-title":"Symmetrical in vivo transcription of mitochondrial DNA in HeLa cells","volume":"68","author":"Aloni","year":"1971","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510130725_B37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00312616","article-title":"The complete and symmetric transcription of the main non coding region of rat mitochondrial genome: in vivo mapping of heavy and light transcripts","volume":"17","author":"Sbis\u00e0","year":"1990","journal-title":"Curr. Genet."},{"key":"key\n\t\t\t\t20170510130725_B38","first-page":"125","article-title":"Identification of a stable RNA encoded by the H-strand of the mouse mitochondrial D-loop region and a conserved sequence motif immediately upstream of its polyadenylation site","volume":"4","author":"Vijayasarathy","year":"1995","journal-title":"Gene Expr."},{"key":"key\n\t\t\t\t20170510130725_B39","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1046\/j.1432-1033.2003.03461.x","article-title":"Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A\/T rich sequence motif and sequence specific DNA binding proteins","volume":"270","author":"Camasamudram","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20170510130725_B40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0014-5793(01)02345-6","article-title":"Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species","volume":"494","author":"Selwood","year":"2001","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170510130725_B41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-1119(97)00404-6","article-title":"Mammalian mitochondrial D-loop region structural analysis: identification of new conserved sequences and their functional and evolutionary implications","volume":"205","author":"Sbis\u00e0","year":"1997","journal-title":"Gene"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/38\/19\/6577\/16769448\/gkq527.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T18:35:10Z","timestamp":1635532510000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkq527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,20]]},"references-count":41,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2010,6,20]]},"published-print":{"date-parts":[[2010,10]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkq527","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6,20]]}}}