{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:17:57Z","timestamp":1772507877625,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":1807,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1093\/nar\/gkr1117","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T05:55:26Z","timestamp":1322891726000},"page":"2518-2526","source":"Crossref","is-referenced-by-count":19,"title":["Mre11 modulates the fidelity of fusion between short telomeres in human cells"],"prefix":"10.1093","volume":"40","author":[{"given":"Maira","family":"Tankimanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Capper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boitelo T.","family":"Letsolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rowson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhiannon E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethan","family":"Britt-Compton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Malcolm R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan M.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"key\n\t\t\t\t20170512132250_gkr1117-B1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: the protein complex that shapes and safeguards human telomeres","volume":"19","author":"de Lange","year":"2005","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0960-9822(03)00542-6","article-title":"DNA damage foci at dysfunctional telomeres","volume":"13","author":"Takai","year":"2003","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nature06065","article-title":"Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1","volume":"448","author":"Denchi","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d'Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0092-8674(01)00335-X","article-title":"Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase","volume":"105","author":"Hopfner","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B6","doi-asserted-by":"crossref","first-page":"45171","DOI":"10.1074\/jbc.M308705200","article-title":"Regulation of Mre11\/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrm805","article-title":"The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling","volume":"3","author":"D'Amours","year":"2002","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1097-2765(00)80097-0","article-title":"The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks","volume":"1","author":"Paull","year":"1998","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.dnarep.2009.04.017","article-title":"DNA end resection: many nucleases make light work","volume":"8","author":"Mimitou","year":"2009","journal-title":"DNA Repair"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/29.6.1317","article-title":"DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways","volume":"29","author":"de Jager","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cell.2008.08.017","article-title":"Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair","volume":"135","author":"Williams","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/genetics\/163.3.843","article-title":"Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae","volume":"163","author":"Yu","year":"2003","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B14","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1002\/j.1460-2075.1996.tb00890.x","article-title":"Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways","volume":"15","author":"Boulton","year":"1996","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B15","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1534\/genetics.107.076539","article-title":"Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining","volume":"176","author":"Lee","year":"2007","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B16","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1128\/MCB.23.23.8820-8828.2003","article-title":"Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences","volume":"23","author":"Ma","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(02)00770-5","article-title":"Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations","volume":"109","author":"Zhu","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B18","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.20070255","article-title":"Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination","volume":"204","author":"Soulas-Sprauel","year":"2007","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature06020","article-title":"IgH class switching and translocations use a robust non-classical end-joining pathway","volume":"449","author":"Yan","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B20","doi-asserted-by":"crossref","first-page":"16479","DOI":"10.1074\/jbc.M312796200","article-title":"Delineation of the role of the Mre11 complex in class switch recombination","volume":"279","author":"Lahdesmaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B21","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S0960-9822(02)01179-X","article-title":"DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2","volume":"12","author":"Smogorzewska","year":"2002","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/ncb1444","article-title":"Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination","volume":"8","author":"Celli","year":"2006","journal-title":"Nat. Cell. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B23","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","article-title":"Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity","volume":"11","author":"Counter","year":"1992","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B24","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1101\/gad.439107","article-title":"The nature of telomere fusion and a definition of the critical telomere length in human cells","volume":"21","author":"Capper","year":"2007","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B25","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1182\/blood-2010-02-272104","article-title":"Telomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis","volume":"116","author":"Lin","year":"2010","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B26","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/nar\/gkp1183","article-title":"Fusion of short telomeres in human cells is characterised by extensive deletion and microhomology and can result in complex rearrangements","volume":"38","author":"Letsolo","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B27","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1091\/mbc.11.10.3265","article-title":"Protection of telomeres by the Ku protein in fission yeast","volume":"11","author":"Baumann","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B28","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1038\/sj.emboj.7600236","article-title":"Molecular analysis of telomere fusions in Arabidopsis : multiple pathways for chromosome end-joining","volume":"23","author":"Heacock","year":"2004","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B29","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1128\/MCB.01354-06","article-title":"DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse","volume":"27","author":"Maser","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B30","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/hmg\/10.11.1155","article-title":"hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay","volume":"10","author":"Pitts","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(00)81547-0","article-title":"The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder","volume":"99","author":"Stewart","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.dnarep.2004.04.009","article-title":"Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis","volume":"3","author":"Taylor","year":"2004","journal-title":"DNA Repair"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B33","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1128\/MCB.19.4.3103","article-title":"Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis","volume":"19","author":"Bond","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1084","article-title":"Extensive allelic variation and ultrashort telomeres in senescent human cells","volume":"33","author":"Baird","year":"2003","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/hmg\/ddi486","article-title":"Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans","volume":"15","author":"Britt-Compton","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B36","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/hmg\/ddh221","article-title":"MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder","volume":"13","author":"Delia","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B37","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S1097-2765(03)00455-6","article-title":"Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1\/ATLD1) mice","volume":"12","author":"Theunissen","year":"2003","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2008.08.015","article-title":"Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation","volume":"135","author":"Buis","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nature08196","article-title":"Multiple roles for MRE11 at uncapped telomeres","volume":"460","author":"Deng","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B40","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/emboj\/19.7.1731","article-title":"DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells","volume":"19","author":"Dominguez","year":"2000","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512132250_gkr1117-B41","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1074\/jbc.M307913200","article-title":"Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts","volume":"279","author":"Lee","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/40\/6\/2518\/16955516\/gkr1117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:12:15Z","timestamp":1639833135000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkr1117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2012,3]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkr1117","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}