{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:43:31Z","timestamp":1791085411067,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":1939,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1093\/nar\/gkr415","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T00:38:25Z","timestamp":1311035905000},"page":"8881-8890","source":"Crossref","is-referenced-by-count":40,"title":["Selective inhibition of MBNL1\u2013CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2) \u2020"],"prefix":"10.1093","volume":"39","author":[{"given":"Chun-Ho","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivasa Rao","family":"Ramisetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Baranger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"key\n\t\t\t\t20170510161759_B1","volume-title":"Myotonic Dystrophy","author":"Harper","year":"2001","edition":"3rd edn"},{"key":"key\n\t\t\t\t20170510161759_B2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0092-8674(92)90154-5","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3\u2032-end of a transcript encoding a protein kinase family member","volume":"68","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170510161759_B3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1062125","article-title":"Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9","volume":"293","author":"Liquori","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170510161759_B4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrg1691","article-title":"Diseases of unstable repeat expansion: mechanisms and common principles","volume":"6","author":"Gatchel","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170510161759_B5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.neuro.29.051605.113014","article-title":"RNA-mediated neuromuscular disorders","volume":"29","author":"Ranum","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170510161759_B6","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0505873102","article-title":"The structural basis of myotonic dystrophy from the crystal structure of CUG repeats","volume":"102","author":"Mooers","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510161759_B7","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMcibr064708","article-title":"A reversal of misfortune for myotonic dystrophy?","volume":"355","author":"Cooper","year":"2006","journal-title":"New England J. Med."},{"key":"key\n\t\t\t\t20170510161759_B8","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1073\/pnas.0905780106","article-title":"Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy","volume":"106","author":"Mulders","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510161759_B9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1173110","article-title":"Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA","volume":"325","author":"Wheeler","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170510161759_B10","doi-asserted-by":"crossref","first-page":"18551","DOI":"10.1073\/pnas.0903234106","article-title":"Pentamidine reverses the splicing defects associated with myotonic dystrophy","volume":"106","author":"Warf","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510161759_B11","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1021\/ja9020149","article-title":"Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3","volume":"131","author":"Pushechnikov","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"key\n\t\t\t\t20170510161759_B12","doi-asserted-by":"crossref","first-page":"16068","DOI":"10.1073\/pnas.0901824106","article-title":"A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding","volume":"106","author":"Arambula","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170510161759_B13","doi-asserted-by":"crossref","first-page":"16254","DOI":"10.1021\/ja804398y","article-title":"Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA\u2212MBNL1 interaction in vitro : discovery of lead compounds targeting myotonic dystrophy (DM1)","volume":"130","author":"Gareiss","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"key\n\t\t\t\t20170510161759_B14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/cb900025w","article-title":"Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2","volume":"4","author":"Lee","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"key\n\t\t\t\t20170510161759_B15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cbic.200900716","article-title":"The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies","volume":"11","author":"Disney","year":"2010","journal-title":"ChemBioChem"},{"key":"key\n\t\t\t\t20170510161759_B16","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1093\/nar\/gkm601","article-title":"Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs","volume":"35","author":"Yuan","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510161759_B17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/(SICI)1521-3765(19990104)5:1<381::AID-CHEM381>3.0.CO;2-T","article-title":"From molecular ribbons to a molecular fabric","volume":"5","author":"Mascal","year":"1999","journal-title":"Chem. Eur. J."},{"key":"key\n\t\t\t\t20170510161759_B18","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.talanta.2007.12.039","article-title":"Synthesis of a novel fluorescent probe based on acridine skeleton used for sensitive determination of DNA","volume":"75","author":"Wu","year":"2008","journal-title":"Talanta"},{"key":"key\n\t\t\t\t20170510161759_B19","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1261\/rna.610607","article-title":"MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T","volume":"13","author":"Warf","year":"2007","journal-title":"RNA"},{"key":"key\n\t\t\t\t20170510161759_B20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature05977","article-title":"Expandable DNA repeats and human disease","volume":"447","author":"Mirkin","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170510161759_B21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1212\/01.WNL.0000054481.84978.F9","article-title":"Myotonic dystrophy type 2: molecular, diagnostic and clinical spectrum","volume":"60","author":"Day","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170510161759_B22","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.nmd.2006.03.010","article-title":"140th ENMC International workshop: myotonic dystrophy DM2\/PROMM and other myotonic dystrophies with guidelines on management","volume":"16","author":"Udd","year":"2006","journal-title":"Neuromuscul. Disord."},{"key":"key\n\t\t\t\t20170510161759_B23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.2700","article-title":"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure","volume":"288","author":"Mathews","year":"1999","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170510161759_B24","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1093\/nar\/gkg766","article-title":"RNA structure of trinucleotide repeats associated with human neurological diseases","volume":"31","author":"Sobczak","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510161759_B25","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1039\/B817733N","article-title":"Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand","author":"Ong","year":"2009","journal-title":"Chem. Commun."},{"key":"key\n\t\t\t\t20170510161759_B26","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr185","article-title":"The origin of genetic instability in CCTG repeats","author":"Lam","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510161759_B27","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1093\/nar\/gkp350","article-title":"Structural insights into CUG repeats containing the \u2018stretched U\u2013U wobble\u2019: implications for myotonic dystrophy","volume":"37","author":"Kiliszek","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170510161759_B28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0371-1951(58)80025-9","article-title":"Ultraviolet absorption spectra of derivatives of symmetric triazine\u2014II: oxo-triazines and their acyclic analogs","volume":"12","author":"Hirt","year":"1958","journal-title":"Spectrochim. Acta"},{"key":"key\n\t\t\t\t20170510161759_B29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/jo01256a011","article-title":"Protonation of 2,4-diaminopyrimidines. I. Dissociation constants and substituent effects","volume":"34","author":"Roth","year":"1969","journal-title":"J. Org. Chem."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/39\/20\/8881\/16777813\/gkr415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:42:20Z","timestamp":1522680140000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkr415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":29,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2011,7,18]]},"published-print":{"date-parts":[[2011,11]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkr415","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}