{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:30:44Z","timestamp":1770460244805,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":1792,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1093\/nar\/gkr905","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T06:57:33Z","timestamp":1320821853000},"page":"2065-2075","source":"Crossref","is-referenced-by-count":11,"title":["Specialization of an Exonuclease III family enzyme in the repair of 3\u2032 DNA lesions during base excision repair in the human pathogen Neisseria meningitidis"],"prefix":"10.1093","volume":"40","author":[{"given":"Jan","family":"Silhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztofa","family":"Nagorska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Freemont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph M.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff S.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"key\n\t\t\t\t20170512092359_gkr905-B1","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2006","edition":"2nd edn"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1146\/annurev.bi.63.070194.004411","article-title":"Repair of oxidative damage to DNA: enzymology and biology","volume":"63","author":"Demple","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mrfmmm.2003.07.002","article-title":"Mutagenicity, toxicity and repair of DNA base damage induced by oxidation","volume":"531","author":"Bjelland","year":"2003","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B4","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1021\/cr040481v","article-title":"Catalytic promiscuity and the divergent evolution of DNA repair enzymes","volume":"106","author":"O'Brien","year":"2006","journal-title":"Chem. Rev."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B5","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1093\/nar\/18.17.5069","article-title":"Analysis of class II (hydrolytic) and class I (beta-lyase) apurinic\/apyrimidinic endonucleases with a synthetic DNA substrate","volume":"18","author":"Levin","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2003.10.002","article-title":"Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae","volume":"3","author":"Boiteux","year":"2004","journal-title":"DNA Repair"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1269\/jrr.39.137","article-title":"3\u2032-blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Escherichia coli","volume":"39","author":"Takemoto","year":"1998","journal-title":"J. Radiat. Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B8","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1073\/pnas.83.20.7731","article-title":"Exonuclease III and endonuclease IV remove 3\u2032 blocks from DNA synthesis primers in H2O2-damaged Escherichia coli","volume":"83","author":"Demple","year":"1986","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0959-440X(99)80006-2","article-title":"Envisioning the molecular choreography of DNA base excision repair","volume":"9","author":"Parikh","year":"1999","journal-title":"Curr. Opin. Struct. Biol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B10","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/sj.emboj.7601593","article-title":"AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis","volume":"26","author":"Carpenter","year":"2007","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B11","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1073\/pnas.88.24.11450","article-title":"Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes","volume":"88","author":"Demple","year":"1991","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B12","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0969-2126(97)00303-1","article-title":"Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway","volume":"5","author":"Parikh","year":"1997","journal-title":"Structure"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B13","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.1093\/emboj\/16.21.6548","article-title":"The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites","volume":"16","author":"Gorman","year":"1997","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0021-9258(18)51775-0","article-title":"A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. Ii. Characterization of the exonuclease activity","volume":"239","author":"Richardson","year":"1964","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B15","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1093\/nar\/19.21.5907","article-title":"Two distinct human DNA diesterases that hydrolyze 3\u2032-blocking deoxyribose fragments from oxidized DNA","volume":"19","author":"Chen","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B16","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/S0021-9258(19)69623-7","article-title":"Purification and characterization of an apurinic\/apyrimidinic endonuclease from HeLa cells","volume":"256","author":"Kane","year":"1981","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molcel.2004.06.003","article-title":"AP endonuclease-independent DNA base excision repair in human cells","volume":"15","author":"Wiederhold","year":"2004","journal-title":"Mol. Cell."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0021-9258(18)51774-9","article-title":"A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity","volume":"239","author":"Richardson","year":"1964","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-1119(85)90120-9","article-title":"Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors","volume":"33","author":"Yanisch-Perron","year":"1985","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-1119(96)00404-0","article-title":"Plasmids for ectopic integration in Bacillus subtilis","volume":"180","author":"Guerout-Fleury","year":"1996","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/genetics\/154.2.523","article-title":"A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation","volume":"154","author":"Mehr","year":"2000","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B22","article-title":"Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway","author":"Grippon","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B23","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1074\/jbc.M509137200","article-title":"A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1","volume":"281","author":"Krusong","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrmicro1324","article-title":"Meningococcal genome dynamics","volume":"4","author":"Davidsen","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2180-9-7","article-title":"Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair","volume":"9","author":"Tibballs","year":"2009","journal-title":"BMC Microbiol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/nar\/24.3.418","article-title":"Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage","volume":"24","author":"Dizdaroglu","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B27","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1038\/sj.emboj.7600689","article-title":"C \u2013> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases","volume":"24","author":"An","year":"2005","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B28","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1093\/nar\/6.11.3673","article-title":"Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli","volume":"6","author":"Chetsanga","year":"1979","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B29","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/carcin\/10.10.1905","article-title":"Excision of the imidazole ring-opened form of N-2-aminofluorene-C(8)-guanine adduct in poly(dG-dC) by Escherichia coli formamidopyrimidine-DNA glycosylase","volume":"10","author":"Boiteux","year":"1989","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B30","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1093\/nar\/gkf618","article-title":"Human DNA glycosylases of the bacterial Fpg\/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA","volume":"30","author":"Morland","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B31","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1073\/pnas.85.8.2709","article-title":"The mutY gene: a mutator locus in Escherichia coli that generates G.C\u2014T.A transversions","volume":"85","author":"Nghiem","year":"1988","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B32","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1021\/bi00096a022","article-title":"Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals","volume":"32","author":"Dizdaroglu","year":"1993","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/bj2620581","article-title":"Mechanism of DNA strand nicking at apurinic\/apyrimidinic sites by Escherichia coli [formamidopyrimidine]DNA glycosylase","volume":"262","author":"Bailly","year":"1989","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B34","doi-asserted-by":"crossref","first-page":"21585","DOI":"10.1074\/jbc.273.34.21585","article-title":"Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue","volume":"273","author":"Ikeda","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B35","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/nar\/gkm018","article-title":"A rapid reaction analysis of uracil DNA glycosylase indicates an active mechanism of base flipping","volume":"35","author":"Bellamy","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0076-6879(80)65028-9","article-title":"Exonuclease III of Escherichia coli K-12, an AP endonuclease","volume":"65","author":"Rogers","year":"1980","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/bj2420565","article-title":"Escherichia coli endonuclease III is not an endonuclease but a beta-elimination catalyst","volume":"242","author":"Bailly","year":"1987","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B38","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0960-9822(02)00641-3","article-title":"Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily","volume":"6","author":"Nash","year":"1996","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512092359_gkr905-B40","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1128\/MCB.00677-09","article-title":"DNA 3\u2032-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress","volume":"29","author":"Breslin","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512092359_gkr905-B41","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/nar\/gkp021","article-title":"Identification of a residue critical for the excision of 3\u2032-blocking ends in apurinic\/apyrimidinic endonucleases of the Xth family","volume":"37","author":"Castillo-Acosta","year":"2009","journal-title":"Nucleic Acids Res."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/40\/5\/2065\/16955045\/gkr905.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T20:03:41Z","timestamp":1639598621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkr905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,11,8]]},"published-print":{"date-parts":[[2012,3]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkr905","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,8]]}}}