{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:56:58Z","timestamp":1782928618554,"version":"3.54.5"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":1593,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1093\/nar\/gks580","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T04:29:33Z","timestamp":1340944173000},"page":"8406-8415","source":"Crossref","is-referenced-by-count":13,"title":["Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells"],"prefix":"10.1093","volume":"40","author":[{"given":"Nami","family":"Haruta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshino","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"key\n\t\t\t\t20170512094835_gks580-B1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.dnarep.2006.05.005","article-title":"DNA repair: from molecular mechanism to human disease","volume":"5","author":"Friedberg","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"key\n\t\t\t\t20170512094835_gks580-B2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/cr.2007.114","article-title":"Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA","volume":"18","author":"Andersen","year":"2008","journal-title":"Cell Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B3","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/cbic.200500139","article-title":"The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO","volume":"6","author":"Ulrich","year":"2005","journal-title":"Chembiochem"},{"key":"key\n\t\t\t\t20170512094835_gks580-B4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature07963","article-title":"Principles of ubiquitin and SUMO modifications in DNA repair","volume":"458","author":"Bergink","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512094835_gks580-B5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1097-2765(01)00278-7","article-title":"The Y-family of DNA polymerases","volume":"8","author":"Ohmori","year":"2001","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170512094835_gks580-B6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.biochem.74.082803.133250","article-title":"Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function","volume":"74","author":"Prakash","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170512094835_gks580-B7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1128\/MMBR.00034-08","article-title":"Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance","volume":"73","author":"Waters","year":"2009","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"key\n\t\t\t\t20170512094835_gks580-B8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/genetics\/92.2.397","article-title":"Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev3 mutant strains","volume":"92","author":"Lawrence","year":"1979","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512094835_gks580-B9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF00383316","article-title":"REV7, a new gene concerned with UV mutagenesis in yeast","volume":"200","author":"Lawrence","year":"1985","journal-title":"Mol. Gen. Genet."},{"key":"key\n\t\t\t\t20170512094835_gks580-B10","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1093\/nar\/gkg489","article-title":"Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlight","volume":"31","author":"Kozmin","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/382729a0","article-title":"Deoxycytidyl transferase activity of yeast REV1 protein","volume":"382","author":"Nelson","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512094835_gks580-B12","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1126\/science.1116336","article-title":"Rev1 employs a novel mechanism of DNA synthesis using a protein template","volume":"309","author":"Nair","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170512094835_gks580-B13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1101\/gad.882301","article-title":"Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites","volume":"15","author":"Haracska","year":"2001","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170512094835_gks580-B14","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/nar\/gki279","article-title":"Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1","volume":"33","author":"Ross","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1534\/genetics.110.124172","article-title":"The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant","volume":"187","author":"Wiltrout","year":"2011","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512094835_gks580-B16","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.283.5404.1001","article-title":"Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta","volume":"283","author":"Johnson","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170512094835_gks580-B17","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/emboj\/18.12.3491","article-title":"Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity","volume":"18","author":"Masutani","year":"1999","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512094835_gks580-B18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/21447","article-title":"The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta","volume":"399","author":"Masutani","year":"1999","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512094835_gks580-B19","doi-asserted-by":"crossref","first-page":"12093","DOI":"10.1073\/pnas.2134223100","article-title":"Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta","volume":"100","author":"Washington","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170512094835_gks580-B20","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/genetics\/147.4.1557","article-title":"The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism","volume":"147","author":"McDonald","year":"1997","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512094835_gks580-B21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s004380050698","article-title":"Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability","volume":"257","author":"Roush","year":"1998","journal-title":"Mol. Gen. Genet."},{"key":"key\n\t\t\t\t20170512094835_gks580-B22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/MCB.21.1.185-188.2001","article-title":"Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts","volume":"21","author":"Yu","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170512094835_gks580-B23","doi-asserted-by":"crossref","first-page":"18767","DOI":"10.1074\/jbc.M211838200","article-title":"Role of DNA polymerase eta in the UV mutation spectrum in human cells","volume":"278","author":"Stary","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512094835_gks580-B24","doi-asserted-by":"crossref","first-page":"36835","DOI":"10.1074\/jbc.274.52.36835","article-title":"Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta","volume":"274","author":"Washington","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512094835_gks580-B25","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/nar\/30.5.1262","article-title":"UV-induced T\u2013>C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase eta in vivo","volume":"30","author":"Zhang","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B26","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1534\/genetics.105.052480","article-title":"The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae : insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis","volume":"172","author":"Abdulovic","year":"2006","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512094835_gks580-B27","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.1021\/bi0346704","article-title":"Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta","volume":"42","author":"Xie","year":"2003","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170512094835_gks580-B28","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature07580","article-title":"RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light","volume":"457","author":"Hishida","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170512094835_gks580-B29","volume-title":"Methods in yeast genetics","author":"Amberg","year":"2005"},{"key":"key\n\t\t\t\t20170512094835_gks580-B30","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/emboj\/21.8.2019","article-title":"Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6 -dependent DNA damage tolerance pathway","volume":"21","author":"Hishida","year":"2002","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512094835_gks580-B31","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1128\/MCB.00453-10","article-title":"Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells","volume":"30","author":"Hishida","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170512094835_gks580-B32","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1093\/emboj\/18.22.6561","article-title":"Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase","volume":"18","author":"Pellicioli","year":"1999","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170512094835_gks580-B33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cub.2009.11.061","article-title":"Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis","volume":"20","author":"Hendriks","year":"2010","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170512094835_gks580-B34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0027-5107(92)90086-H","article-title":"Photoreactivation implicates cyclobutane dimers as the major promutagenic UVB lesions in yeast","volume":"268","author":"Armstrong","year":"1992","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B35","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0168-9525(97)01246-8","article-title":"Sunlight and the onset of skin cancer","volume":"13","author":"Brash","year":"1997","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170512094835_gks580-B36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0027-5107(00)00038-5","article-title":"Enzymatic photoreactivation: 50 years and counting","volume":"451","author":"Sancar","year":"2000","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1158\/1055-9965.EPI-04-0564","article-title":"Tanning beds, sunlamps, and risk of cutaneous malignant melanoma","volume":"14","author":"Gallagher","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20170512094835_gks580-B38","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1073\/pnas.90.9.4216","article-title":"Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers","volume":"90","author":"Ziegler","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170512094835_gks580-B39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/sj.jidsp.5640173","article-title":"Ultraviolet radiation induced signature mutations in photocarcinogenesis","volume":"4","author":"Wikonkal","year":"1999","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"key\n\t\t\t\t20170512094835_gks580-B40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0027-5107(01)00131-2","article-title":"Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast","volume":"478","author":"Pavlov","year":"2001","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170512094835_gks580-B41","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/bi00462a015","article-title":"A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy","volume":"29","author":"Frederico","year":"1990","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170512094835_gks580-B42","doi-asserted-by":"crossref","first-page":"24174","DOI":"10.1074\/jbc.270.41.24174","article-title":"Deamination of cytosine-containing pyrimidine photodimers in UV-irradiated DNA. Significance for UV light mutagenesis","volume":"270","author":"Barak","year":"1995","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170512094835_gks580-B43","doi-asserted-by":"crossref","first-page":"10172","DOI":"10.1021\/bi960001x","article-title":"Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC\u2013>TT transitions","volume":"35","author":"Peng","year":"1996","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170512094835_gks580-B44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.dnarep.2004.09.006","article-title":"The role of DNA polymerase eta in UV mutational spectra","volume":"4","author":"Choi","year":"2005","journal-title":"DNA Repair (Amst)"},{"key":"key\n\t\t\t\t20170512094835_gks580-B45","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/nar\/gkh342","article-title":"Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer","volume":"32","author":"Takasawa","year":"2004","journal-title":"Nucleic Acids Res."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/40\/17\/8406\/16957254\/gks580.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T21:26:15Z","timestamp":1642627575000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gks580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":45,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2012,6,28]]},"published-print":{"date-parts":[[2012,9]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gks580","relation":{},"ISSN":["1362-4962","0305-1048"],"issn-type":[{"value":"1362-4962","type":"electronic"},{"value":"0305-1048","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}