{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:57:54Z","timestamp":1790243874006,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":1033,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Light constitutes a primary signal whereby endogenous circadian clocks are synchronized (\u2018entrained\u2019) with the day\/night cycle. The molecular mechanisms underlying this vital process are known to require gene activation, yet are incompletely understood. Here, the light-induced transcriptome in the zebrafish central clock organ, the pineal gland, was characterized by messenger RNA (mRNA) sequencing (mRNA-seq) and microarray analyses, resulting in the identification of multiple light-induced mRNAs. Interestingly, a considerable portion of the molecular clock (14 genes) is light-induced in the pineal gland. Four of these genes, encoding the transcription factors dec1, reverbb1, e4bp4-5 and e4bp4-6, differentially affected clock- and light-regulated promoter activation, suggesting that light-input is conveyed to the core clock machinery via diverse mechanisms. Moreover, we show that dec1, as well as the core clock gene per2, is essential for light-entrainment of rhythmic locomotor activity in zebrafish larvae. Additionally, we used microRNA (miRNA) sequencing (miR-seq) and identified pineal-enhanced and light-induced miRNAs. One such miRNA, miR-183, is shown to downregulate e4bp4-6 mRNA through a 3\u2032UTR target site, and importantly, to regulate the rhythmic mRNA levels of aanat2, the key enzyme in melatonin synthesis. Together, this genome-wide approach and functional characterization of light-induced factors indicate a multi-level regulation of the circadian clockwork by light.<\/jats:p>","DOI":"10.1093\/nar\/gkt1359","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:11:33Z","timestamp":1389766293000},"page":"3750-3767","source":"Crossref","is-referenced-by-count":78,"title":["The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light"],"prefix":"10.1093","volume":"42","author":[{"given":"Zohar","family":"Ben-Moshe","sequence":"first","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Alon","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"},{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mracek","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Faigenbloom","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Tovin","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad D.","family":"Vatine","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"},{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Gothilf","sequence":"additional","affiliation":[{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"},{"name":"1 George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, 2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, 3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and 4Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2022080109285750000_gkt1359-B1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1146\/annurev.ph.55.030193.000313","article-title":"Temporal organization: reflections of a Darwinian clock-watcher","volume":"55","author":"Pittendrigh","year":"1993","journal-title":"Annu. Rev. 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Sci."},{"key":"2022080109285750000_gkt1359-B5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1101\/sqb.2007.72.003","article-title":"Circadian photoreception in vertebrates","volume":"72","author":"Doyle","year":"2007","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"2022080109285750000_gkt1359-B6","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.febslet.2011.04.007","article-title":"It's time to swim! zebrafish and the circadian clock","volume":"585","author":"Vatine","year":"2011","journal-title":"FEBS Lett."},{"key":"2022080109285750000_gkt1359-B7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1749-6632.2009.04435.x","article-title":"Structural and functional evolution of the pineal melatonin system in vertebrates","volume":"1163","author":"Falcon","year":"2009","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2022080109285750000_gkt1359-B8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/35003589","article-title":"Light acts directly on organs and cells in culture to set the vertebrate circadian clock","volume":"404","author":"Whitmore","year":"2000","journal-title":"Nature"},{"key":"2022080109285750000_gkt1359-B9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.physiol.63.1.677","article-title":"Circadian photoperception","volume":"63","author":"Devlin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"2022080109285750000_gkt1359-B10","doi-asserted-by":"crossref","first-page":"14712","DOI":"10.1073\/pnas.0704588104","article-title":"Light signaling to the zebrafish circadian clock by Cryptochrome 1a","volume":"104","author":"Tamai","year":"2007","journal-title":"Proc. Natl Acad. Sci. 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