{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:08:16Z","timestamp":1776424096321,"version":"3.51.2"},"reference-count":117,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":1155,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lens induction is a classical embryologic model to study cell fate determination. It has been proposed earlier that specific changes in core histone modifications accompany the process of cell fate specification and determination. The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression. Herein, we performed conditional inactivation of both CBP and p300 in the ectodermal cells that give rise to the lens placode. Inactivation of both CBP and p300 resulted in the dramatic discontinuation of all aspects of lens specification and organogenesis, resulting in aphakia. The CBP\/p300\u2212\/\u2212 ectodermal cells are viable and not prone to apoptosis. These cells showed reduced expression of Six3 and Sox2, while expression of Pax6 was not upregulated, indicating discontinuation of lens induction. Consequently, expression of \u03b1B- and \u03b1A-crystallins was not initiated. Mutant ectoderm exhibited markedly reduced levels of histone H3 K18 and K27 acetylation, subtly increased H3 K27me3 and unaltered overall levels of H3 K9ac and H3 K4me3. Our data demonstrate that CBP and p300 are required to establish lens cell-type identity during lens induction, and suggest that posttranslational histone modifications are integral to normal cell fate determination in the mammalian lens.<\/jats:p>","DOI":"10.1093\/nar\/gkt824","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T21:02:59Z","timestamp":1379106179000},"page":"10199-10214","source":"Crossref","is-referenced-by-count":59,"title":["Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300"],"prefix":"10.1093","volume":"41","author":[{"given":"Louise","family":"Wolf","sequence":"first","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"},{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbur","family":"Harrison","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xie","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"},{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningna","family":"Xiao","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingkun","family":"Kong","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salil A.","family":"Lachke","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"},{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali R.","family":"Kuracha","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Govindarajan","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology 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K.","family":"Brindle","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Ashery-Padan","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Beebe","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Overbeek","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Cvekl","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"},{"name":"1 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, 2Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, 4Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, 5Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, 6Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, 7Department of Surgery, Creighton University, Omaha, NE 68178, USA, 8Department of Biochemistry, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA and 9Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"2024100208460839300_gkt824-B1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/epi.5.1.10449","article-title":"Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases","volume":"5","author":"Bedford","year":"2010","journal-title":"Epigenetics"},{"key":"2024100208460839300_gkt824-B2","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1128\/MCB.23.21.7611-7627.2003","article-title":"Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin","volume":"23","author":"McManus","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2024100208460839300_gkt824-B3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/emboj.2010.318","article-title":"Distinct roles of GCN5\/PCAF-mediated H3K9ac and CBP\/p300-mediated H3K18\/27ac in nuclear receptor transactivation","volume":"30","author":"Jin","year":"2011","journal-title":"EMBO J."},{"key":"2024100208460839300_gkt824-B4","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/emboj.2010.235","article-title":"CBP\/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation","volume":"29","author":"Kasper","year":"2010","journal-title":"EMBO J."},{"key":"2024100208460839300_gkt824-B5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2011.01.024","article-title":"Functional and mechanistic diversity of distal transcription enhancers","volume":"144","author":"Bulger","year":"2011","journal-title":"Cell"},{"key":"2024100208460839300_gkt824-B6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.devcel.2011.06.008","article-title":"Enhancers: from developmental genetics to the genetics of common human disease","volume":"21","author":"Williamson","year":"2011","journal-title":"Dev. 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Ophthalmol."},{"key":"2024100208460839300_gkt824-B12","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/MCB.26.3.789-809.2006","article-title":"Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development","volume":"26","author":"Kasper","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2024100208460839300_gkt824-B13","doi-asserted-by":"crossref","first-page":"H1255","DOI":"10.1152\/ajpheart.01266.2008","article-title":"CBP and p300 are essential for renin cell identity and morphological integrity of the kidney","volume":"296","author":"Gomez","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024100208460839300_gkt824-B14","doi-asserted-by":"crossref","first-page":"e69721","DOI":"10.1371\/journal.pone.0069721","article-title":"Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression","volume":"8","author":"Hennig","year":"2013","journal-title":"PLoS One"},{"key":"2024100208460839300_gkt824-B15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0168-9525(92)90280-H","article-title":"Embryonic lens induction: shedding light on vertebrate tissue determination","volume":"8","author":"Grainger","year":"1992","journal-title":"Trends Genet."},{"key":"2024100208460839300_gkt824-B16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1098\/rstb.2010.0175","article-title":"The lens: a classical model of embryonic induction providing new insights into cell determination in early development","volume":"366","author":"Gunhaga","year":"2011","journal-title":"Philos. Trans. R. 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