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In this study, we annotated the expression pattern of all box C\/D snoRNAs in normal and cancer cell lines independent of their functions. The results indicate that C\/D snoRNAs are expressed as two distinct forms differing in their ends with respect to boxes C and D and in their terminal stem length. Both forms are overexpressed in cancer cell lines but display a conserved end distribution. Surprisingly, the long forms are more dependent than the short forms on the expression of the core snoRNP protein NOP58, thought to be essential for C\/D snoRNA production. In contrast, a subset of short forms are dependent on the splicing factor RBFOX2. Analysis of the potential secondary structure of both forms indicates that the k-turn motif required for binding of NOP58 is less stable in short forms which are thus less likely to mature into a canonical snoRNP. Taken together the data suggest that C\/D snoRNAs are divided into at least two groups with distinct maturation and functional preferences.<\/jats:p>","DOI":"10.1093\/nar\/gku664","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T02:04:11Z","timestamp":1406685851000},"page":"10073-10085","source":"Crossref","is-referenced-by-count":41,"title":["Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency"],"prefix":"10.1093","volume":"42","author":[{"given":"Gabrielle","family":"Deschamps-Francoeur","sequence":"first","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Garneau","sequence":"additional","affiliation":[{"name":"Laboratoire de g\u00e9nomique fonctionnelle de l'Universit\u00e9 de Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"},{"name":"D\u00e9partement de microbiologie et d'infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Dupuis-Sandoval","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Roy","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Frappier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Catala","sequence":"additional","affiliation":[{"name":"Laboratoire de g\u00e9nomique fonctionnelle de l'Universit\u00e9 de Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"},{"name":"D\u00e9partement de microbiologie et d'infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Couture","sequence":"additional","affiliation":[{"name":"Laboratoire de g\u00e9nomique fonctionnelle de l'Universit\u00e9 de Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"},{"name":"D\u00e9partement de microbiologie et d'infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Barbe-Marcoux","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Abou-Elela","sequence":"additional","affiliation":[{"name":"Laboratoire de g\u00e9nomique fonctionnelle de l'Universit\u00e9 de Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"},{"name":"D\u00e9partement de microbiologie et d'infectiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Scott","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biochimie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec J1E 4K8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"2019070601432328400_B1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1006\/meth.2001.1250","article-title":"Mapping 2\u2032-O-methyl groups in ribosomal RNA","volume":"25","author":"Maden","year":"2001","journal-title":"Methods"},{"key":"2019070601432328400_B2","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1128\/MCB.24.13.5797-5807.2004","article-title":"Human box H\/ACA pseudouridylation guide RNA machinery","volume":"24","author":"Kiss","year":"2004","journal-title":"Mol. 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