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The structurally disordered N-terminal tail of DDB2 contains seven lysines identified as major sites for ubiquitination that target the protein for proteasomal degradation; however, the precise biological functions of these modifications remained unknown. By exogenous expression of mutant DDB2 proteins in normal human fibroblasts, here we show that the N-terminal tail of DDB2 is involved in regulation of cellular responses to UV. By striking contrast with behaviors of exogenous DDB2, the endogenous DDB2 protein was stabilized even after UV irradiation as a function of the XPC expression level. Furthermore, XPC competitively suppressed ubiquitination of DDB2 in vitro, and this effect was significantly promoted by centrin-2, which augments the DNA damage-recognition activity of XPC. Based on these findings, we propose that in cells exposed to UV, DDB2 is protected by XPC from ubiquitination and degradation in a stochastic manner; thus XPC allows DDB2 to initiate multiple rounds of repair events, thereby contributing to the persistence of cellular DNA repair capacity.<\/jats:p>","DOI":"10.1093\/nar\/gkv038","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T04:30:48Z","timestamp":1422419448000},"page":"1700-1713","source":"Crossref","is-referenced-by-count":58,"title":["Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein"],"prefix":"10.1093","volume":"43","author":[{"given":"Syota","family":"Matsumoto","sequence":"first","affiliation":[{"name":"1Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan"},{"name":"2Graduate School of Science, Kobe University, Kobe 657-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Fischer","sequence":"additional","affiliation":[{"name":"3Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"4National Institute of Radiological Sciences, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Dohmae","sequence":"additional","affiliation":[{"name":"5Global Research Cluster, RIKEN, Wako 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[{"name":"6Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Mori","sequence":"additional","affiliation":[{"name":"7Advanced Medical Research Center, Nara Medical University, Kashihara 634-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Nishi","sequence":"additional","affiliation":[{"name":"1Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"1Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Sakai","sequence":"additional","affiliation":[{"name":"1Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan"},{"name":"2Graduate School of Science, Kobe University, Kobe 657-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"8Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas H.","family":"Thom\u00e4","sequence":"additional","affiliation":[{"name":"3Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Sugasawa","sequence":"additional","affiliation":[{"name":"1Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan"},{"name":"2Graduate School of Science, Kobe University, Kobe 657-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"2023042013040932100_B1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. 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