{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:59:02Z","timestamp":1775123942941,"version":"3.50.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Res"],"published-print":{"date-parts":[[2016,3,18]]},"DOI":"10.1093\/nar\/gkw060","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T01:25:14Z","timestamp":1454721914000},"page":"2310-2322","source":"Crossref","is-referenced-by-count":23,"title":["Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors"],"prefix":"10.1093","volume":"44","author":[{"given":"Anna","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Corona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Sp\u00f6ring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Maccioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Di\u00a0Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Bodem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Tramontano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta M.","family":"W\u00f6hrl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"2016031802122976000_44.5.2310.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13471"},{"key":"2016031802122976000_44.5.2310.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80185-9"},{"key":"2016031802122976000_44.5.2310.3","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.10.4832-4842.2001"},{"key":"2016031802122976000_44.5.2310.4","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1908"},{"key":"2016031802122976000_44.5.2310.5","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200009010-00002"},{"key":"2016031802122976000_44.5.2310.6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020010"},{"key":"2016031802122976000_44.5.2310.7","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1128\/JVI.70.9.5930-5934.1996","article-title":"Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility","volume":"70","author":"Harrigan","year":"1996","journal-title":"J. Virol."},{"key":"2016031802122976000_44.5.2310.8","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1128\/JVI.70.11.8010-8018.1996","article-title":"An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3\u2032-azido-3\u2032-deoxythymidine","volume":"70","author":"Hooker","year":"1996","journal-title":"J. Virol."},{"key":"2016031802122976000_44.5.2310.9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2179-2184.2002"},{"key":"2016031802122976000_44.5.2310.10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06597-11"},{"key":"2016031802122976000_44.5.2310.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.2398"},{"key":"2016031802122976000_44.5.2310.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.02.004"},{"key":"2016031802122976000_44.5.2310.13","first-page":"67","article-title":"HIV-1 drug resistance mutations: an updated framework for the second decade of HAART","volume":"10","author":"Shafer","year":"2008","journal-title":"AIDS Rev."},{"key":"2016031802122976000_44.5.2310.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2004.10.013"},{"key":"2016031802122976000_44.5.2310.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073744"},{"key":"2016031802122976000_44.5.2310.16","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/JVI.70.2.1086-1090.1996","article-title":"Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy","volume":"70","author":"Iversen","year":"1996","journal-title":"J. Virol."},{"key":"2016031802122976000_44.5.2310.17","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.1.70"},{"key":"2016031802122976000_44.5.2310.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.01.007"},{"key":"2016031802122976000_44.5.2310.19","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000189851.21441.f1"},{"key":"2016031802122976000_44.5.2310.20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/135965350601100209","article-title":"The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations","volume":"11","author":"White","year":"2006","journal-title":"Antivir. Ther."},{"key":"2016031802122976000_44.5.2310.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.022525"},{"key":"2016031802122976000_44.5.2310.22","doi-asserted-by":"publisher","DOI":"10.1086\/505711"},{"key":"2016031802122976000_44.5.2310.23","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281ac229b"},{"key":"2016031802122976000_44.5.2310.24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308806200"},{"key":"2016031802122976000_44.5.2310.25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00683-06"},{"key":"2016031802122976000_44.5.2310.26","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00465-12"},{"key":"2016031802122976000_44.5.2310.27","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-7"},{"key":"2016031802122976000_44.5.2310.28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/AAC.42.2.447","article-title":"A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer","volume":"42","author":"Boyer","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"2016031802122976000_44.5.2310.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00381-7"},{"key":"2016031802122976000_44.5.2310.30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1087"},{"key":"2016031802122976000_44.5.2310.31","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0147-7"},{"key":"2016031802122976000_44.5.2310.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.05.064"},{"key":"2016031802122976000_44.5.2310.33","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00056-14"},{"key":"2016031802122976000_44.5.2310.34","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12051"},{"key":"2016031802122976000_44.5.2310.35","doi-asserted-by":"publisher","DOI":"10.1159\/000343101"},{"key":"2016031802122976000_44.5.2310.36","doi-asserted-by":"publisher","DOI":"10.1021\/jm2000757"},{"key":"2016031802122976000_44.5.2310.37","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1413-1415.2004"},{"key":"2016031802122976000_44.5.2310.38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2006.00404.x"},{"key":"2016031802122976000_44.5.2310.39","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.10.5685-5693.2003"},{"key":"2016031802122976000_44.5.2310.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.12.015"},{"key":"2016031802122976000_44.5.2310.41","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0142"},{"key":"2016031802122976000_44.5.2310.42","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10550"},{"key":"2016031802122976000_44.5.2310.43","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20500"},{"key":"2016031802122976000_44.5.2310.44","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817bbe93"},{"key":"2016031802122976000_44.5.2310.45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/135965350701200210","article-title":"The V118I mutation as a marker of advanced HIV infection and disease progression","volume":"12","author":"Zaccarelli","year":"2007","journal-title":"Antivir. Ther."},{"key":"2016031802122976000_44.5.2310.46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.351551"},{"key":"2016031802122976000_44.5.2310.47","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823c8b69"},{"key":"2016031802122976000_44.5.2310.48","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02084-05"},{"key":"2016031802122976000_44.5.2310.49","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.54-61.2003"},{"key":"2016031802122976000_44.5.2310.50","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5394.1669"},{"key":"2016031802122976000_44.5.2310.51","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00716-10"},{"key":"2016031802122976000_44.5.2310.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609642104"},{"key":"2016031802122976000_44.5.2310.53","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr005"},{"key":"2016031802122976000_44.5.2310.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001781"},{"key":"2016031802122976000_44.5.2310.55","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0153"},{"key":"2016031802122976000_44.5.2310.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.11.021"},{"key":"2016031802122976000_44.5.2310.57","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1128\/JVI.72.4.2890-2895.1998","article-title":"The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity","volume":"72","author":"Rezende","year":"1998","journal-title":"J. Virol."},{"key":"2016031802122976000_44.5.2310.58","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00915-10"},{"key":"2016031802122976000_44.5.2310.59","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00302-14"},{"key":"2016031802122976000_44.5.2310.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.03.004"},{"key":"2016031802122976000_44.5.2310.61","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.4971-4977.2006"},{"key":"2016031802122976000_44.5.2310.62","doi-asserted-by":"publisher","DOI":"10.1021\/bi970512z"},{"key":"2016031802122976000_44.5.2310.63","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.2.1512-1523.2003"},{"key":"2016031802122976000_44.5.2310.64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.34"},{"key":"2016031802122976000_44.5.2310.65","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00859-09"},{"key":"2016031802122976000_44.5.2310.66","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.178"},{"key":"2016031802122976000_44.5.2310.67","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777435733"},{"key":"2016031802122976000_44.5.2310.68","doi-asserted-by":"publisher","DOI":"10.2174\/092986710792065045"},{"key":"2016031802122976000_44.5.2310.69","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319100009"},{"key":"2016031802122976000_44.5.2310.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.056"},{"key":"2016031802122976000_44.5.2310.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.11.002"},{"key":"2016031802122976000_44.5.2310.72","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03605-14"},{"key":"2016031802122976000_44.5.2310.73","doi-asserted-by":"publisher","DOI":"10.1021\/jm400405z"},{"key":"2016031802122976000_44.5.2310.74","doi-asserted-by":"publisher","DOI":"10.1016\/0196-8858(91)90017-D"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/44\/5\/2310\/17438475\/gkw060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T14:09:48Z","timestamp":1654265388000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkw060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,4]]},"references-count":74,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,18]]},"published-print":{"date-parts":[[2016,3,18]]}},"alternative-id":["10.1093\/nar\/gkw060"],"URL":"https:\/\/doi.org\/10.1093\/nar\/gkw060","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,4]]}}}