{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:51:02Z","timestamp":1790776262130,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Res"],"published-print":{"date-parts":[[2016,4,20]]},"DOI":"10.1093\/nar\/gkw061","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T01:25:14Z","timestamp":1454721914000},"page":"3330-3350","source":"Crossref","is-referenced-by-count":23,"title":["Kissing-loop interaction between 5\u2032 and 3\u2032 ends of tick-borne Langat virus genome \u2018bridges the gap\u2019 between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine development"],"prefix":"10.1093","volume":"44","author":[{"given":"Konstantin A.","family":"Tsetsarkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Pletnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"2016042007224761000_44.7.3330.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2010.01.002"},{"key":"2016042007224761000_44.7.3330.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00206-1"},{"key":"2016042007224761000_44.7.3330.3","doi-asserted-by":"publisher","DOI":"10.1038\/178581a0"},{"key":"2016042007224761000_44.7.3330.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1746"},{"key":"2016042007224761000_44.7.3330.5","first-page":"89","article-title":"Vaccination of human volunteers against Russian spring-summer (RSS) virus complex with attenuated Langat E5 virus","volume":"42","author":"Price","year":"1970","journal-title":"Bull. World Health Organ."},{"key":"2016042007224761000_44.7.3330.6","unstructured":"Smorodincev A.A. Dubov A.V. Live vaccines against tick-borne encephalitis. In: Smorodincev AA , editor. Tick-borne encephalitis and its vaccine prophylaxis. Leningrad: Meditsina; 1986. p. 190-211."},{"key":"2016042007224761000_44.7.3330.7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02091-10"},{"key":"2016042007224761000_44.7.3330.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004852"},{"key":"2016042007224761000_44.7.3330.9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2014.04.001","article-title":"Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions","volume":"456\u2013457","author":"Teterina","year":"2014","journal-title":"Virology"},{"key":"2016042007224761000_44.7.3330.10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01112-07"},{"key":"2016042007224761000_44.7.3330.11","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0067"},{"key":"2016042007224761000_44.7.3330.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212379109"},{"key":"2016042007224761000_44.7.3330.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.06.028"},{"key":"2016042007224761000_44.7.3330.14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02677-14"},{"key":"2016042007224761000_44.7.3330.15","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00243-13"},{"key":"2016042007224761000_44.7.3330.16","doi-asserted-by":"publisher","DOI":"10.3390\/v3091739"},{"key":"2016042007224761000_44.7.3330.17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.8.4099-4113.2006"},{"key":"2016042007224761000_44.7.3330.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.04.035"},{"key":"2016042007224761000_44.7.3330.19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr237"},{"key":"2016042007224761000_44.7.3330.20","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0220"},{"key":"2016042007224761000_44.7.3330.21","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0793"},{"key":"2016042007224761000_44.7.3330.22","unstructured":"Sambrook J. Fritsch E. Maniatis T. Molecular Cloning: a Laboratory Manual. 2nd edn. NY: Cold Spring Harbor Laboratory; 1989."},{"key":"2016042007224761000_44.7.3330.23","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-4-1"},{"key":"2016042007224761000_44.7.3330.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.06.014"},{"key":"2016042007224761000_44.7.3330.25","unstructured":"Team R.C. R: A language and environment for statistical computing. Vienna: R Foundation for statistical computing; 2015."},{"key":"2016042007224761000_44.7.3330.26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.17.8259-8267.2001"},{"key":"2016042007224761000_44.7.3330.27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg595"},{"key":"2016042007224761000_44.7.3330.28","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.07125-11"},{"key":"2016042007224761000_44.7.3330.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.05.008"},{"key":"2016042007224761000_44.7.3330.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092056"},{"key":"2016042007224761000_44.7.3330.31","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18723-0"},{"key":"2016042007224761000_44.7.3330.32","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1128\/JVI.67.8.4956-4963.1993","article-title":"Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice","volume":"67","author":"Pletnev","year":"1993","journal-title":"J. Virol."},{"key":"2016042007224761000_44.7.3330.33","doi-asserted-by":"publisher","DOI":"10.1261\/rna.783108"},{"key":"2016042007224761000_44.7.3330.34","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-3-r13"},{"key":"2016042007224761000_44.7.3330.35","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0846"},{"key":"2016042007224761000_44.7.3330.36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002465"},{"key":"2016042007224761000_44.7.3330.37","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.6631-6643.2005"},{"key":"2016042007224761000_44.7.3330.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.10.007"},{"key":"2016042007224761000_44.7.3330.39","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3369"},{"key":"2016042007224761000_44.7.3330.40","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01159-10"},{"key":"2016042007224761000_44.7.3330.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.02.006"},{"key":"2016042007224761000_44.7.3330.42","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90455-4"},{"key":"2016042007224761000_44.7.3330.43","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.14.6719-6728.2001"},{"key":"2016042007224761000_44.7.3330.44","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19462-0"},{"key":"2016042007224761000_44.7.3330.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.01.016"},{"key":"2016042007224761000_44.7.3330.46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02042-09"},{"key":"2016042007224761000_44.7.3330.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.009"},{"key":"2016042007224761000_44.7.3330.48","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.18.10004-10014.2003"},{"key":"2016042007224761000_44.7.3330.49","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.3.2265-2270.2003"},{"key":"2016042007224761000_44.7.3330.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.01.014"},{"key":"2016042007224761000_44.7.3330.51","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"2016042007224761000_44.7.3330.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"2016042007224761000_44.7.3330.53","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1552"},{"key":"2016042007224761000_44.7.3330.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.06.017"},{"key":"2016042007224761000_44.7.3330.55","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1128\/JVI.70.6.3930-3937.1996","article-title":"Dengue type 4 virus mutants containing deletions in the 3\u2019 noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys","volume":"70","author":"Men","year":"1996","journal-title":"J. Virol."},{"key":"2016042007224761000_44.7.3330.56","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/JVI.72.3.2132-2140.1998","article-title":"Spontaneous and engineered deletions in the 3\u2019 noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus","volume":"72","author":"Mandl","year":"1998","journal-title":"J. Virol."},{"key":"2016042007224761000_44.7.3330.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03978.x"},{"key":"2016042007224761000_44.7.3330.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.015"},{"key":"2016042007224761000_44.7.3330.59","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1038\/ncomms5386","article-title":"MiR-9 promotes microglial activation by targeting MCPIP1","volume":"5","author":"Yao","year":"2014","journal-title":"Nat. Commun."},{"key":"2016042007224761000_44.7.3330.60","first-page":"280","article-title":"Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells","volume":"6","author":"Liu","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"2016042007224761000_44.7.3330.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)27002-8"},{"key":"2016042007224761000_44.7.3330.62","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.4.4.553"},{"key":"2016042007224761000_44.7.3330.63","doi-asserted-by":"crossref","unstructured":"Halstead S.B. Jacobson J. Japanese encephalitis virus vaccines. In: Plotkin S Orenstein W Offit P , editors. Vaccines. Philadelphia: Elsevier; 2008. p. 311-352.","DOI":"10.1016\/B978-1-4160-3611-1.50021-0"},{"key":"2016042007224761000_44.7.3330.64","first-page":"191","article-title":"A novel principle of attenuation for the development of new generation live flavivirus vaccines","volume":"18","author":"Kofler","year":"2004","journal-title":"Arch. Virol. Suppl."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/44\/7\/3330\/17438292\/gkw061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T02:04:05Z","timestamp":1600135445000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkw061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,4]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,4,20]]},"published-print":{"date-parts":[[2016,4,20]]}},"alternative-id":["10.1093\/nar\/gkw061"],"URL":"https:\/\/doi.org\/10.1093\/nar\/gkw061","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,4]]}}}