{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:53:47Z","timestamp":1790394827981,"version":"4.1.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acids Res"],"published-print":{"date-parts":[[2016,12,15]]},"DOI":"10.1093\/nar\/gkw711","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T23:14:12Z","timestamp":1471475652000},"page":"10960-10973","source":"Crossref","is-referenced-by-count":35,"title":["Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease"],"prefix":"10.1093","volume":"44","author":[{"given":"Pilar","family":"Vazquez-Arango","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Vowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hartfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo\u00a0J.\u00a0R.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berhan","family":"Mandefro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Sareen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wade-Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Cowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"2016121521151053000_44.22.10960.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.008"},{"key":"2016121521151053000_44.22.10960.2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/wrna.1257","article-title":"Insights into the U1 small nuclear ribonucleoprotein complex superfamily","volume":"6","author":"Guiro","year":"2015","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2016121521151053000_44.22.10960.3","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120058"},{"key":"2016121521151053000_44.22.10960.4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/wrna.1348","article-title":"The reciprocal regulation between splicing and 3\u2032-end processing","volume":"7","author":"Kaida","year":"2016","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2016121521151053000_44.22.10960.5","doi-asserted-by":"publisher","DOI":"10.1038\/nature12349"},{"key":"2016121521151053000_44.22.10960.6","doi-asserted-by":"publisher","DOI":"10.1038\/nature09479"},{"key":"2016121521151053000_44.22.10960.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.009"},{"key":"2016121521151053000_44.22.10960.8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90064-4"},{"key":"2016121521151053000_44.22.10960.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2777"},{"key":"2016121521151053000_44.22.10960.10","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb961"},{"key":"2016121521151053000_44.22.10960.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.009"},{"key":"2016121521151053000_44.22.10960.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.2412294"},{"key":"2016121521151053000_44.22.10960.13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.18.6255"},{"key":"2016121521151053000_44.22.10960.14","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90263-0"},{"key":"2016121521151053000_44.22.10960.15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.23.6971"},{"key":"2016121521151053000_44.22.10960.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.02.013"},{"key":"2016121521151053000_44.22.10960.17","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90101-2"},{"key":"2016121521151053000_44.22.10960.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2572"},{"key":"2016121521151053000_44.22.10960.19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/oxfordjournals.jbchem.a135550","article-title":"Isolation of U1-snRNP(s) from mouse teratocarcinoma cells using immunochemical and biochemical procedures: high proportion of U1a-snRNP to U1b-snRNP","volume":"99","author":"Matsuda","year":"1986","journal-title":"J. Biochem."},{"key":"2016121521151053000_44.22.10960.20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1534\/g3.114.015735","article-title":"Developmental analysis of spliceosomal snRNA isoform expression","volume":"5","author":"Lu","year":"2014","journal-title":"G3"},{"key":"2016121521151053000_44.22.10960.21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.2.351"},{"key":"2016121521151053000_44.22.10960.22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.11.2197"},{"key":"2016121521151053000_44.22.10960.23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.16.4247"},{"key":"2016121521151053000_44.22.10960.24","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/j.1460-2075.1985.tb03813.x","article-title":"The two embryonic U1 RNA genes of Xenopus laevis have both common and gene-specific transcription signals","volume":"4","author":"Krol","year":"1985","journal-title":"EMBO J."},{"key":"2016121521151053000_44.22.10960.25","doi-asserted-by":"publisher","DOI":"10.1101\/gr.142968.112"},{"key":"2016121521151053000_44.22.10960.26","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v7.i1.1"},{"key":"2016121521151053000_44.22.10960.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.09.016"},{"key":"2016121521151053000_44.22.10960.28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914114107"},{"key":"2016121521151053000_44.22.10960.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2012.09.002"},{"key":"2016121521151053000_44.22.10960.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr040330"},{"key":"2016121521151053000_44.22.10960.31","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth902"},{"key":"2016121521151053000_44.22.10960.32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087388"},{"key":"2016121521151053000_44.22.10960.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071098"},{"key":"2016121521151053000_44.22.10960.34","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0121"},{"key":"2016121521151053000_44.22.10960.35","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2388"},{"key":"2016121521151053000_44.22.10960.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.04.009"},{"key":"2016121521151053000_44.22.10960.37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039113"},{"key":"2016121521151053000_44.22.10960.38","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23578"},{"key":"2016121521151053000_44.22.10960.39","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007529"},{"key":"2016121521151053000_44.22.10960.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.01.013"},{"key":"2016121521151053000_44.22.10960.41","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"2016121521151053000_44.22.10960.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81769-9"},{"key":"2016121521151053000_44.22.10960.43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110348"},{"key":"2016121521151053000_44.22.10960.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.04.010"},{"key":"2016121521151053000_44.22.10960.45","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81057-0"},{"key":"2016121521151053000_44.22.10960.46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/wrna.1141","article-title":"The significant other: Splicing by the minor spliceosome","volume":"4","author":"Turunen","year":"2013","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2016121521151053000_44.22.10960.47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202205"},{"key":"2016121521151053000_44.22.10960.48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200587"},{"key":"2016121521151053000_44.22.10960.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.057"},{"key":"2016121521151053000_44.22.10960.50","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7042"},{"key":"2016121521151053000_44.22.10960.51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319280110"},{"key":"2016121521151053000_44.22.10960.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.11.002"},{"key":"2016121521151053000_44.22.10960.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.031"},{"key":"2016121521151053000_44.22.10960.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000921"},{"key":"2016121521151053000_44.22.10960.55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.23.8885"},{"key":"2016121521151053000_44.22.10960.56","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0411-1"},{"key":"2016121521151053000_44.22.10960.57","doi-asserted-by":"publisher","DOI":"10.1038\/nature07677"},{"key":"2016121521151053000_44.22.10960.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.12.009"},{"key":"2016121521151053000_44.22.10960.59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310249110"},{"key":"2016121521151053000_44.22.10960.60","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0475"},{"key":"2016121521151053000_44.22.10960.61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106818"},{"key":"2016121521151053000_44.22.10960.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.08.003"},{"key":"2016121521151053000_44.22.10960.63","doi-asserted-by":"publisher","DOI":"10.1242\/dev.115808"},{"key":"2016121521151053000_44.22.10960.64","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2015","journal-title":"FEBS J."},{"key":"2016121521151053000_44.22.10960.65","doi-asserted-by":"crossref","unstructured":"Mercado G. Castillo V. Soto P. Sidhu A. ER stress and Parkinson disease: Pathological inputs that converge into the secretory pathway. Brain Res. 2016. doi:10.1016\/j.brainres.2016.04.042.","DOI":"10.1016\/j.brainres.2016.04.042"},{"key":"2016121521151053000_44.22.10960.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.019"},{"key":"2016121521151053000_44.22.10960.67","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt316"},{"key":"2016121521151053000_44.22.10960.68","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00227-2"},{"key":"2016121521151053000_44.22.10960.69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140714346"},{"key":"2016121521151053000_44.22.10960.70","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1371\/journal.pcbi.0030196","article-title":"Alternative splicing events identified in human embryonic stem cells and neural progenitors","volume":"3","author":"Yeo","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"2016121521151053000_44.22.10960.71","doi-asserted-by":"crossref","first-page":"560261","DOI":"10.4061\/2011\/560261","article-title":"Alternative splicing in self-renewal of embryonic stem cells","volume":"2011","author":"Cheong","year":"2011","journal-title":"Stem Cells Int."},{"key":"2016121521151053000_44.22.10960.72","doi-asserted-by":"publisher","DOI":"10.1038\/nature12270"},{"key":"2016121521151053000_44.22.10960.73","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00065-06"},{"key":"2016121521151053000_44.22.10960.74","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2141505"},{"key":"2016121521151053000_44.22.10960.75","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt892"},{"key":"2016121521151053000_44.22.10960.76","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3167"},{"key":"2016121521151053000_44.22.10960.77","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155390"},{"key":"2016121521151053000_44.22.10960.78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900028106"},{"key":"2016121521151053000_44.22.10960.79","doi-asserted-by":"publisher","DOI":"10.1101\/gad.229328.113"},{"key":"2016121521151053000_44.22.10960.80","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2005.084"},{"key":"2016121521151053000_44.22.10960.81","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2839"},{"key":"2016121521151053000_44.22.10960.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.011"},{"key":"2016121521151053000_44.22.10960.83","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155085"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/44\/22\/10960\/8452367\/gkw711.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T13:19:38Z","timestamp":1568294378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkw711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,17]]},"references-count":83,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2016,12,15]]},"published-print":{"date-parts":[[2016,12,15]]}},"alternative-id":["10.1093\/nar\/gkw711"],"URL":"https:\/\/doi.org\/10.1093\/nar\/gkw711","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,17]]}}}