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Herein, we report a novel cAMP-mediated response for sensing and responding to UV-induced DNA damage regulated by A-kinase-anchoring protein 12 (AKAP12). AKAP12 is identified as a necessary participant in PKA-mediated phosphorylation of ataxia telangiectasia mutated and Rad3-related (ATR) at S435, a post-translational event required for cAMP-enhanced nucleotide excision repair (NER). Moreover, UV exposure promotes ATR-directed phosphorylation of AKAP12 at S732, which promotes nuclear translocation of AKAP12\u2013ATR-pS435. This complex subsequently recruits XPA to UV DNA damage and enhances 5\u0384 strand incision. Preventing AKAP12's interaction with PKA or with ATR abrogates ATR-pS435 accumulation, delays recruitment of XPA to UV-damaged DNA, impairs NER and increases UV-induced mutagenesis. Our results define a critical role for AKAP12 as an UV-inducible scaffold for PKA-mediated ATR phosphorylation, and identify a repair complex consisting of AKAP12\u2013ATR-pS435-XPA at photodamage, which is essential for cAMP-enhanced NER.<\/jats:p>","DOI":"10.1093\/nar\/gkw871","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T02:48:35Z","timestamp":1475117315000},"page":"10711-10726","source":"Crossref","is-referenced-by-count":21,"title":["Retracted: AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair"],"prefix":"10.1093","volume":"44","author":[{"given":"Stuart G.","family":"Jarrett","sequence":"first","affiliation":[{"name":"Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin M.","family":"Wolf\u00a0Horrell","sequence":"additional","affiliation":[{"name":"Markey Cancer Center, University of Kentucky 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