{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:42:37Z","timestamp":1768480957856,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,19]]},"DOI":"10.1093\/nar\/gkx118","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:56:49Z","timestamp":1487149009000},"page":"5170-5182","source":"Crossref","is-referenced-by-count":24,"title":["TIEG1 modulates \u03b2-catenin sub-cellular localization and enhances Wnt signaling in bone"],"prefix":"10.1093","volume":"45","author":[{"given":"Malayannan","family":"Subramaniam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"Cicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin S.","family":"Pitel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S.","family":"Bruinsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly H.","family":"Nelson\u00a0Holte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah G.","family":"Withers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini M.","family":"Rajamannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Secreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Venuprasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Hawse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"key\n\t\t\t\t20170518045145_B1","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1093\/nar\/23.23.4907","article-title":"Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts","volume":"23","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170518045145_B2","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1210\/me.2007-0253","article-title":"Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain","volume":"22","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170518045145_B3","doi-asserted-by":"crossref","first-page":"20255","DOI":"10.1074\/jbc.C000135200","article-title":"Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells","volume":"275","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/1097-4644(20000901)78:3<380::AID-JCB4>3.0.CO;2-L","article-title":"Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): regulation by specific members of the TGF-beta family","volume":"78","year":"2000","journal-title":"J. Cell Biochem."},{"key":"key\n\t\t\t\t20170518045145_B5","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1038\/sj.onc.1205681","article-title":"TGFbeta inducible early gene enhances TGFbeta\/Smad-dependent transcriptional responses","volume":"21","year":"2002","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170518045145_B6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jcb.10299","article-title":"Transcriptional regulation of Smad2 is required for enhancement of TGFbeta\/Smad signaling by TGFbeta inducible early gene","volume":"87","year":"2002","journal-title":"J. Cell Biochem."},{"key":"key\n\t\t\t\t20170518045145_B7","doi-asserted-by":"crossref","first-page":"30754","DOI":"10.1074\/jbc.M204812200","article-title":"Modulation of transforming growth factor beta (TGFbeta)\/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue","volume":"277","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B8","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1128\/MCB.25.3.1191-1199.2005","article-title":"TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro","volume":"25","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170518045145_B9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2009.12.171","article-title":"TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts","volume":"392","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170518045145_B10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/biof.67","article-title":"Functional role of KLF10 in multiple disease processes","volume":"36","year":"2010","journal-title":"BioFactors (Oxford, England)"},{"key":"key\n\t\t\t\t20170518045145_B11","doi-asserted-by":"crossref","first-page":"e17522","DOI":"10.1371\/journal.pone.0017522","article-title":"TGF-\u03b2 inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK\/ERK signaling pathways","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518045145_B12","doi-asserted-by":"crossref","first-page":"e19429","DOI":"10.1371\/journal.pone.0019429","article-title":"TIEG1\/KLF10 modulates Runx2 expression and activity in osteoblasts","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518045145_B13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bbrc.2016.01.112","article-title":"TIEG1 enhances Osterix expression and mediates its induction by TGFbeta and BMP2 in osteoblasts","volume":"470","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170518045145_B14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1359\/jbmr.090729","article-title":"Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men","volume":"25","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"key\n\t\t\t\t20170518045145_B15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2008.08.120","article-title":"Gene expression profile of the bone microenvironment in human fragility fracture bone","volume":"44","year":"2009","journal-title":"Bone"},{"key":"key\n\t\t\t\t20170518045145_B16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bone.2006.05.021","article-title":"TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture","volume":"39","year":"2006","journal-title":"Bone"},{"key":"key\n\t\t\t\t20170518045145_B17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bone.2008.02.004","article-title":"TIEG-null mice display an osteopenic gender-specific phenotype","volume":"42","year":"2008","journal-title":"Bone"},{"key":"key\n\t\t\t\t20170518045145_B18","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/jbmr.2142","article-title":"TGFbeta inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton","volume":"29","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"key\n\t\t\t\t20170518045145_B19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jcb.21049","article-title":"TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: discovery and characterization of a novel signaling pathway","volume":"100","year":"2007","journal-title":"J. Cell Biochem."},{"key":"key\n\t\t\t\t20170518045145_B20","doi-asserted-by":"crossref","first-page":"e18418","DOI":"10.1371\/journal.pone.0018418","article-title":"Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518045145_B21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/mp.2012.163","article-title":"Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway","volume":"19","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"key\n\t\t\t\t20170518045145_B22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12565-009-0061-y","article-title":"Transforming growth factor beta inducible apoptotic cascade in epithelial cells during rat molar tooth eruptions","volume":"85","year":"2010","journal-title":"Anat. Sci. Int."},{"key":"key\n\t\t\t\t20170518045145_B23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518045145_B24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518045145_B25","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa013444","article-title":"High bone density due to a mutation in LDL-receptor-related protein 5","volume":"346","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170518045145_B26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1086\/338450","article-title":"A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait","volume":"70","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170518045145_B27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.200201089","article-title":"Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor","volume":"157","year":"2002","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170518045145_B28","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1359\/jbmr.040907","article-title":"Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6","volume":"19","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"key\n\t\t\t\t20170518045145_B29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2004.02.018","article-title":"Bone biomechanical properties in LRP5 mutant mice","volume":"35","year":"2004","journal-title":"Bone"},{"key":"key\n\t\t\t\t20170518045145_B30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","year":"2005","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20170518045145_B31","doi-asserted-by":"crossref","first-page":"21162","DOI":"10.1074\/jbc.M501900200","article-title":"Essential role of beta-catenin in postnatal bone acquisition","volume":"280","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B32","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.01428-09","article-title":"Osteocyte Wnt\/beta-catenin signaling is required for normal bone homeostasis","volume":"30","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170518045145_B33","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/dev.126.20.4557","article-title":"Multiple roles for activated LEF\/TCF transcription complexes during hair follicle development and differentiation","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170518045145_B34","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1182\/blood-2007-03-077685","article-title":"Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo","volume":"111","year":"2008","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170518045145_B35","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.4049\/jimmunol.1003801","article-title":"Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth","volume":"186","year":"2011","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170518045145_B36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1359\/JBMR.050210","article-title":"TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro","volume":"20","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"key\n\t\t\t\t20170518045145_B37","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1172\/JCI24140","article-title":"Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals","volume":"115","year":"2005","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170518045145_B38","doi-asserted-by":"crossref","first-page":"20505","DOI":"10.1074\/jbc.M800851200","article-title":"Msx2 exerts bone anabolism via canonical Wnt signaling","volume":"283","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B39","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/MCB.02120-05","article-title":"E11\/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation","volume":"26","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170518045145_B40","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1093\/nar\/gkq363","article-title":"Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq","volume":"38","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170518045145_B41","doi-asserted-by":"crossref","first-page":"e88890","DOI":"10.1371\/journal.pone.0088890","article-title":"beta-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518045145_B42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tibs.2004.03.006","article-title":"Advances in protein kinase B signalling: AKTion on multiple fronts","volume":"29","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20170518045145_B43","doi-asserted-by":"crossref","first-page":"20715","DOI":"10.1074\/jbc.M703224200","article-title":"Wnt\/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha","volume":"282","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B44","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1074\/jbc.R600015200","article-title":"Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors","volume":"281","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: diseases and therapies","volume":"5","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170518045145_B46","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly","volume":"272","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20170518045145_B47","doi-asserted-by":"crossref","first-page":"17479","DOI":"10.1074\/jbc.C000880200","article-title":"Akt participation in the Wnt signaling pathway through Dishevelled","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2826.2011.02186.x","article-title":"Oestradiol regulates beta-catenin-mediated transcription in neurones","volume":"24","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"key\n\t\t\t\t20170518045145_B49","doi-asserted-by":"crossref","first-page":"36168","DOI":"10.1074\/jbc.M112.344747","article-title":"A phytoestrogen diarylheptanoid mediates estrogen receptor\/Akt\/glycogen synthase kinase 3beta protein-dependent activation of the Wnt\/beta-catenin signaling pathway","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170518045145_B50","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/MCB.01844-08","article-title":"Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3\/beta-catenin signaling","volume":"30","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170518045145_B51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-5793(00)01889-5","article-title":"Lactate transport in rat adipocytes: identification of monocarboxylate transporter 1 (MCT1) and its modulation during streptozotocin-induced diabetes","volume":"479","year":"2000","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170518045145_B52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/dbio.1997.8552","article-title":"Activation of the Wnt signaling pathway: a molecular mechanism for lithium action","volume":"185","year":"1997","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170518045145_B53","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170518045145_B54","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/382638a0","article-title":"Functional interaction of beta-catenin with the transcription factor LEF-1","volume":"382","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518045145_B55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos","volume":"86","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518045145_B56","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00018-010-0541-1","article-title":"Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs","volume":"68","year":"2011","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/45\/9\/5170\/17183496\/gkx118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T13:42:06Z","timestamp":1719063726000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkx118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,2,15]]},"published-print":{"date-parts":[[2017,5,19]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx118","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}