{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:56:55Z","timestamp":1783673815842,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,2]]},"DOI":"10.1093\/nar\/gkx155","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T20:10:23Z","timestamp":1488485423000},"page":"6087-6097","source":"Crossref","is-referenced-by-count":25,"title":["RNA\u2013protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers"],"prefix":"10.1093","volume":"45","author":[{"given":"Margaret J.","family":"Lange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong\u00a0D.\u00a0M.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie K.","family":"Callaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u00a0C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"key\n\t\t\t\t20170531015547_B1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1006\/jmbi.1996.0667","article-title":"Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase","volume":"264","year":"1996","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170531015547_B2","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1073\/pnas.89.15.6988","article-title":"RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase","volume":"89","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170531015547_B3","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1093\/nar\/gkf522","article-title":"Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1","volume":"30","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170531015547_B4","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1038\/mt.2012.158","article-title":"Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing","volume":"20","year":"2012","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170531015547_B5","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.1128\/JVI.76.13.6545-6557.2002","article-title":"Potent inhibition of human immunodeficiency virus type 1 replication by template analog reverse transcriptase inhibitors derived by SELEX (systematic evolution of ligands by exponential enrichment)","volume":"76","year":"2002","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ymthe.2005.01.013","article-title":"Aptamers directed to HIV-1 reverse transcriptase display greater efficacy over small hairpin RNAs targeted to viral RNA in blocking HIV-1 replication","volume":"11","year":"2005","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170531015547_B7","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1128\/JVI.76.8.4068-4072.2002","article-title":"Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication","volume":"76","year":"2002","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B8","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1128\/JVI.01923-06","article-title":"Cross-clade inhibition of recombinant human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVcpz reverse transcriptases by RNA pseudoknot aptamers","volume":"81","year":"2007","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B9","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1038\/mtna.2012.62","article-title":"Potent inhibition of HIV-1 reverse transcriptase and replication by nonpseudoknot, \u2018UCAA-motif\u2019 RNA aptamers","volume":"2","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"key\n\t\t\t\t20170531015547_B10","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/nar\/gks1190","article-title":"High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase","volume":"41","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170531015547_B11","doi-asserted-by":"crossref","first-page":"25712","DOI":"10.1074\/jbc.M604460200","article-title":"Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication","volume":"281","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015547_B12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1089\/aid.2006.0262","article-title":"Single-stranded DNA aptamer RT1t49 inhibits RT polymerase and RNase H functions of HIV type 1, HIV type 2, and SIVCPZ RTs","volume":"23","year":"2007","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"key\n\t\t\t\t20170531015547_B13","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1093\/nar\/gkn891","article-title":"Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases","volume":"36","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170531015547_B14","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1093\/nar\/gkr381","article-title":"Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates","volume":"39","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170531015547_B15","doi-asserted-by":"crossref","first-page":"E246","DOI":"10.3390\/v8090246","article-title":"On the selective packaging of genomic RNA by HIV-1","volume":"8","year":"2016","journal-title":"Viruses"},{"key":"key\n\t\t\t\t20170531015547_B16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.febslet.2009.11.038","article-title":"Formation of the tRNALys packaging complex in HIV-1","volume":"584","year":"2010","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170531015547_B17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.virol.2008.07.015","article-title":"Interactions of reverse transcriptase sequences in Pol with Gag and LysRS in the HIV-1 tRNALys3 packaging\/annealing complex","volume":"380","year":"2008","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170531015547_B18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virol.2004.08.006","article-title":"Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor","volume":"328","year":"2004","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170531015547_B19","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature00939","article-title":"Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein","volume":"418","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170531015547_B20","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1128\/JVI.02833-06","article-title":"Selective and nonselective packaging of cellular RNAs in retrovirus particles","volume":"81","year":"2007","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B21","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1128\/JVI.00856-12","article-title":"cis-Acting determinants of 7SL RNA packaging by HIV-1","volume":"86","year":"2012","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrmicro3503","article-title":"HIV-1 capsid: the multifaceted key player in HIV-1 infection","volume":"13","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"key\n\t\t\t\t20170531015547_B23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-62703-730-3_2","article-title":"Screening inhibitory potential of anti-HIV RT RNA aptamers","volume":"1103","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170531015547_B24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nbt0997-871","article-title":"Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo","volume":"15","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170531015547_B25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J","article-title":"Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia","volume":"18","year":"1965","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20170531015547_B26","first-page":"1472","article-title":"T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III","volume":"2","year":"1984","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170531015547_B27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.6200935","article-title":"Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS","volume":"224","year":"1984","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015547_B28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/aid.1989.5.253","article-title":"Origin of the HIV-susceptible human CD4+ cell line H9","volume":"5","year":"1989","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"key\n\t\t\t\t20170531015547_B29","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1128\/JVI.70.5.2809-2824.1996","article-title":"Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells","volume":"70","year":"1996","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B30","doi-asserted-by":"crossref","first-page":"13553","DOI":"10.1128\/JVI.78.24.13553-13561.2004","article-title":"In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques","volume":"78","year":"2004","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170531015547_B31","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nsmb785","article-title":"The stoichiometry of Gag protein in HIV-1","volume":"11","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20170531015547_B32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature01707","article-title":"The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA","volume":"424","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170531015547_B33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1742-4690-3-57","article-title":"The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference","volume":"3","year":"2006","journal-title":"Retrovirology"},{"key":"key\n\t\t\t\t20170531015547_B34","doi-asserted-by":"crossref","first-page":"e1005897","DOI":"10.1371\/journal.ppat.1005897","article-title":"A novel entry\/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infection","volume":"12","year":"2016","journal-title":"PLoS Pathog."},{"key":"key\n\t\t\t\t20170531015547_B35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature19098","article-title":"HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis","volume":"536","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170531015547_B36","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.biocel.2004.02.020","article-title":"Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66\/p51 heterodimer formation","volume":"36","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170531015547_B37","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1002\/prot.24594","article-title":"The p66 immature precursor of HIV-1 reverse transcriptase","volume":"82","year":"2014","journal-title":"Proteins"},{"key":"key\n\t\t\t\t20170531015547_B38","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1093\/emboj\/17.15.4535","article-title":"The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor","volume":"17","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170531015547_B39","doi-asserted-by":"crossref","first-page":"8986","DOI":"10.1016\/S0021-9258(19)38799-X","article-title":"Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention","volume":"265","year":"1990","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015547_B40","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1126\/science.2548279","article-title":"Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease","volume":"245","year":"1989","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015547_B41","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1128\/JVI.73.6.5079-5088.1999","article-title":"Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase","volume":"73","year":"1999","journal-title":"J. Virol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/45\/10\/6087\/17639552\/gkx155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T03:03:22Z","timestamp":1658718202000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkx155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,3,6]]},"published-print":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx155","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]}}}