{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:09:42Z","timestamp":1791288582338,"version":"4.3.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,2]]},"DOI":"10.1093\/nar\/gkx175","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:35:04Z","timestamp":1488814504000},"page":"6177-6193","source":"Crossref","is-referenced-by-count":78,"title":["TDP-43 suppresses tau expression via promoting its mRNA instability"],"prefix":"10.1093","volume":"45","author":[{"given":"Jianlan","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Xin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"key\n\t\t\t\t20170531015617_B1","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","year":"1986","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B2","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170531015617_B3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","year":"1992","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170531015617_B4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00688184","article-title":"Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis","volume":"74","year":"1987","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0022-510X(70)90063-8","article-title":"Observations on the brains of demented old people","volume":"11","year":"1970","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170531015617_B6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1750-1326-9-43","article-title":"Alpha-synuclein and tau: teammates in neurodegeneration","volume":"9","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"key\n\t\t\t\t20170531015617_B7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00401-012-0987-3","article-title":"Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau","volume":"123","year":"2012","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B8","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015617_B9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015617_B10","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170531015617_B11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.brainres.2007.09.048","article-title":"Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies","volume":"1184","year":"2007","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170531015617_B12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/NEN.0b013e31817713b5","article-title":"Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies","volume":"67","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-014-1269-z","article-title":"TDP-43 is a key player in the clinical features associated with Alzheimer's disease","volume":"127","year":"2014","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170531015617_B15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/NEN.0b013e3181ee7d85","article-title":"TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy","volume":"69","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-013-1211-9","article-title":"Staging TDP-43 pathology in Alzheimer's disease","volume":"127","year":"2014","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.expneurol.2012.05.018","article-title":"TDP-43: a new player on the AD field","volume":"237","year":"2012","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1750-1326-5-51","article-title":"Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Abeta oligomers accumulation","volume":"5","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"key\n\t\t\t\t20170531015617_B19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tibs.2012.03.003","article-title":"TDP-43: gumming up neurons through protein-protein and protein-RNA interactions","volume":"37","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"key\n\t\t\t\t20170531015617_B20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10571-009-9489-9","article-title":"TDP-43 dimerizes in human cells in culture","volume":"30","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"key\n\t\t\t\t20170531015617_B21","doi-asserted-by":"crossref","first-page":"36337","DOI":"10.1074\/jbc.M104236200","article-title":"Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B22","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/nar\/gkp013","article-title":"Structural insights into TDP-43 in nucleic-acid binding and domain interactions","volume":"37","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170531015617_B23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015617_B24","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing","volume":"280","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/MCB.01279-10","article-title":"TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor","volume":"31","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170531015617_B26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2353\/ajpath.2007.070182","article-title":"TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions","volume":"171","year":"2007","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170531015617_B27","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1074\/jbc.275.8.5535","article-title":"Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease","volume":"275","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1523\/JNEUROSCI.07-02-00357.1987","article-title":"Glutamate neurotoxicity in cortical cell culture","volume":"7","year":"1987","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/emboj.2010.310","article-title":"TDP-43 regulates its mRNA levels through a negative feedback loop","volume":"30","year":"2011","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170531015617_B30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jmb.2011.11.003","article-title":"UG repeats\/TDP-43 interactions near 5\u0384 splice sites exert unpredictable effects on splicing modulation","volume":"415","year":"2012","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170531015617_B31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43","volume":"14","year":"2011","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B32","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nn.2778","article-title":"Characterizing the RNA targets and position-dependent splicing regulation by TDP-43","volume":"14","year":"2011","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B33","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1074\/jbc.M110.190884","article-title":"Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes","volume":"286","year":"2011","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B34","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170531015617_B35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000106632","article-title":"The cerebellum in Alzheimer's disease","volume":"8","year":"1997","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"key\n\t\t\t\t20170531015617_B36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1750-1326-6-73","article-title":"Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice","volume":"6","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"key\n\t\t\t\t20170531015617_B37","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1073\/pnas.94.8.4113","article-title":"Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments","volume":"94","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170531015617_B38","doi-asserted-by":"crossref","first-page":"eaag0481","DOI":"10.1126\/scitranslmed.aag0481","article-title":"Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy","volume":"9","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20170531015617_B39","doi-asserted-by":"crossref","first-page":"14639","DOI":"10.1074\/jbc.M110.204453","article-title":"Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease","volume":"286","year":"2011","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B40","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1471-4159.1992.tb09432.x","article-title":"Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein","volume":"59","year":"1992","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170531015617_B41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2013.03.001","article-title":"Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system","volume":"105","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"key\n\t\t\t\t20170531015617_B42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","year":"2013","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170531015617_B43","first-page":"497","article-title":"Increased tau messenger RNA in Alzheimer's disease hippocampus","volume":"137","year":"1990","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170531015617_B44","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3233\/JAD-130671","article-title":"Global axonal transport rates are unaltered in htau mice in vivo","volume":"37","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20170531015617_B45","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2003.01879.x","article-title":"Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms","volume":"86","year":"2003","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170531015617_B46","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrn2420","article-title":"Animal models of Alzheimer's disease and frontotemporal dementia","volume":"9","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10048-010-0239-4","article-title":"RNA processing pathways in amyotrophic lateral sclerosis","volume":"11","year":"2010","journal-title":"Neurogenetics"},{"key":"key\n\t\t\t\t20170531015617_B48","doi-asserted-by":"crossref","first-page":"15635","DOI":"10.1074\/jbc.M111.333450","article-title":"TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B49","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4161\/rna.7.4.12205","article-title":"The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation","volume":"7","year":"2010","journal-title":"RNA Biol."},{"key":"key\n\t\t\t\t20170531015617_B50","first-page":"83","article-title":"RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis","volume":"149","year":"2011","journal-title":"Arch. Ital. Biol."},{"key":"key\n\t\t\t\t20170531015617_B51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-010-0659-0","article-title":"Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis","volume":"119","year":"2010","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B52","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mcn.2007.03.007","article-title":"TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein","volume":"35","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B53","doi-asserted-by":"crossref","first-page":"e1000193","DOI":"10.1371\/journal.pgen.1000193","article-title":"Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis","volume":"4","year":"2008","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170531015617_B54","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170531015617_B55","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1468-1331.2008.02195.x","article-title":"ALS and FTLD: two faces of TDP-43 proteinopathy","volume":"15","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B56","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/ana.21392","article-title":"TDP-43 mutation in familial amyotrophic lateral sclerosis","volume":"63","year":"2008","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00401-012-0983-7","article-title":"CSF biomarkers cutoffs: the importance of coincident neuropathological diseases","volume":"124","year":"2012","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B58","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1073\/pnas.1222809110","article-title":"ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170531015617_B59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ymthe.2016.10.013","article-title":"Motor-coordinative and cognitive dysfunction caused by mutant TDP-43 could be reversed by inhibiting Its mitochondrial localization","volume":"25","year":"2017","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170531015617_B60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/17482968.2011.622405","article-title":"Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment","volume":"13","year":"2012","journal-title":"Amyotroph. Lateral Scler."},{"key":"key\n\t\t\t\t20170531015617_B61","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00401-012-1048-7","article-title":"Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion","volume":"125","year":"2013","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40478-016-0301-z","article-title":"Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy","volume":"4","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"key\n\t\t\t\t20170531015617_B63","doi-asserted-by":"crossref","first-page":"10851","DOI":"10.1523\/JNEUROSCI.1630-10.2010","article-title":"Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice","volume":"30","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B64","doi-asserted-by":"crossref","first-page":"7607","DOI":"10.1073\/pnas.0900688106","article-title":"Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity","volume":"106","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170531015617_B65","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M809462200","article-title":"Expression of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies","volume":"284","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170531015617_B66","doi-asserted-by":"crossref","first-page":"10530","DOI":"10.1523\/JNEUROSCI.3421-07.2007","article-title":"Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43","volume":"27","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B67","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/ncomms2303","article-title":"A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology","volume":"3","year":"2012","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20170531015617_B68","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/pmic.201200006","article-title":"Asparaginyl endopeptidase cleaves TDP-43 in brain","volume":"12","year":"2012","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170531015617_B69","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/hmg\/ddp275","article-title":"Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43","volume":"18","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170531015617_B70","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00401-014-1380-1","article-title":"Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine","volume":"129","year":"2015","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170531015617_B71","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrn3121","article-title":"Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration","volume":"13","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170531015617_B72","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddt498","article-title":"TDP-43 Phosphorylation by casein kinase Iepsilon promotes oligomerization and enhances toxicity in vivo","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170531015617_B73","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1038\/ncomms6845","article-title":"An acetylation switch controls TDP-43 function and aggregation propensity","volume":"6","year":"2015","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20170531015617_B74","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury","volume":"68","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170531015617_B75","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/jcbfm.2014.105","article-title":"Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury","volume":"34","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/45\/10\/6177\/17639660\/gkx175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:05:17Z","timestamp":1658721917000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article-lookup\/doi\/10.1093\/nar\/gkx175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":75,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,3,15]]},"published-print":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx175","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}