{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:31:07Z","timestamp":1761766267607,"version":"3.37.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H04720","JP16H01216","JP25.5081"],"award-info":[{"award-number":["JP16H04720","JP16H01216","JP25.5081"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJER1104"],"award-info":[{"award-number":["JPMJER1104"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009024","name":"Exploratory Research for Advanced Technology","doi-asserted-by":"publisher","award":["JPMJER1104"],"award-info":[{"award-number":["JPMJER1104"]}],"id":[{"id":"10.13039\/501100009024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"DOI":"10.1093\/nar\/gkx798","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T15:10:56Z","timestamp":1504105856000},"page":"12152-12169","source":"Crossref","is-referenced-by-count":12,"title":["Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1"],"prefix":"10.1093","volume":"45","author":[{"given":"Tadahiro","family":"Mitani","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yabuta","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606\u20138507, Japan"},{"name":"AMED-CREST, AMED 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitinori","family":"Saitou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606\u20138507, Japan"},{"name":"Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"},{"name":"JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606\u20138501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"key\n\t\t\t\t20180514225542_B1","first-page":"144","article-title":"The selection and function of cell type-specific enhancers","volume":"16","author":"Heinz","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20180514225542_B2","first-page":"1170","article-title":"Ever-changing landscapes: transcriptional enhancers in development and evolution","volume":"167","author":"Long","year":"2016","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B3","first-page":"868","article-title":"Identification and characterization of a novel repressor of beta-interferon gene expression","volume":"5","author":"Keller","year":"1991","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180514225542_B4","first-page":"297","article-title":"Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells","volume":"77","author":"Turner","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B5","first-page":"596","article-title":"Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20180514225542_B6","first-page":"5556","article-title":"B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites","volume":"173","author":"Kuo","year":"2004","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180514225542_B7","first-page":"125","article-title":"PRDI-BF1\/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins","volume":"13","author":"Ren","year":"1999","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180514225542_B8","first-page":"2592","article-title":"Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase","volume":"20","author":"Yu","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180514225542_B9","first-page":"299","article-title":"PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing","volume":"5","author":"Gyory","year":"2004","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20180514225542_B10","first-page":"1421","article-title":"Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation","volume":"29","author":"Su","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180514225542_B11","first-page":"5336","article-title":"An extended set of PRDM1\/BLIMP1 target genes links binding motif type to dynamic repression","volume":"38","author":"Doody","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180514225542_B12","first-page":"2267","article-title":"The Prdm family: expanding roles in stem cells and development","volume":"139","author":"Hohenauer","year":"2012","journal-title":"Development"},{"key":"key\n\t\t\t\t20180514225542_B13","first-page":"517","article-title":"Quantitative dynamics of chromatin remodeling during germ cell specification from mouse embryonic stem cells","volume":"16","author":"Kurimoto","year":"2015","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180514225542_B14","first-page":"e1005375","article-title":"Blimp1\/Prdm1 functions in opposition to Irf1 to maintain neonatal tolerance during postnatal intestinal maturation","volume":"11","author":"Mould","year":"2015","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20180514225542_B15","first-page":"331","article-title":"Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation","volume":"17","author":"Minnich","year":"2016","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20180514225542_B16","first-page":"459","article-title":"Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes","volume":"352","author":"Mackay","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180514225542_B17","first-page":"619","article-title":"Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development","volume":"137","author":"Brzezinski","year":"2010","journal-title":"Development"},{"key":"key\n\t\t\t\t20180514225542_B18","first-page":"6515","article-title":"Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development","volume":"30","author":"Katoh","year":"2010","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20180514225542_B19","first-page":"10585","article-title":"The transcriptional repressor Blimp1\/Prdm1 regulates postnatal reprogramming of intestinal enterocytes","volume":"108","author":"Harper","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180514225542_B20","first-page":"452","article-title":"Blimp1 regulates the transition of neonatal to adult intestinal epithelium","volume":"2","author":"Muncan","year":"2011","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180514225542_B21","first-page":"51","article-title":"Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program","volume":"17","author":"Shaffer","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20180514225542_B22","first-page":"519","article-title":"Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells","volume":"146","author":"Hayashi","year":"2011","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B23","first-page":"7","article-title":"Persistent requirement and alteration of the key targets of PRDM1 during primordial germ cell development in mice","volume":"94","author":"Yamashiro","year":"2016","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20180514225542_B24","first-page":"1640","article-title":"The mouse Crx 5\u2032-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells","volume":"22","author":"Furukawa","year":"2002","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20180514225542_B25","first-page":"89","article-title":"Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine","volume":"879","author":"Gracz","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20180514225542_B26","first-page":"2755","article-title":"The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells","volume":"97","author":"Hayashi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180514225542_B27","first-page":"465","article-title":"In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo","volume":"2","author":"Nojima","year":"2011","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180514225542_B28","first-page":"340","article-title":"Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice","volume":"32","author":"Kagiwada","year":"2013","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180514225542_B29","first-page":"e60","article-title":"SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression","volume":"43","author":"Nakamura","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180514225542_B30","first-page":"57","article-title":"A developmental coordinate of pluripotency among mice, monkeys and humans","volume":"537","author":"Nakamura","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180514225542_B31","first-page":"463","article-title":"Rb interacts with histone deacetylase to repress transcription","volume":"92","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B32","first-page":"1813","article-title":"ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia","volume":"22","author":"Landt","year":"2012","journal-title":"Genome Res."},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20180514225542_B33","first-page":"4516","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180514225542_B34","first-page":"139","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180514225542_B35","first-page":"44","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang\u00a0da","year":"2009","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20180514225542_B36","first-page":"1696","article-title":"MEME-ChIP: motif analysis of large DNA datasets","volume":"27","author":"Machanick","year":"2011","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180514225542_B37","first-page":"2997","article-title":"Use of the \u2018Perceptron\u2019 algorithm to distinguish translational initiation sites in E. coli","volume":"10","author":"Stormo","year":"1982","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180514225542_B38","first-page":"305","article-title":"The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development","volume":"117","author":"Chang","year":"2002","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20180514225542_B39","first-page":"4335","article-title":"Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice","volume":"134","author":"Robertson","year":"2007","journal-title":"Development"},{"key":"key\n\t\t\t\t20180514225542_B40","first-page":"503","article-title":"A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Prdm1-mVenus and Dppa3-ECFP double transgenic reporter","volume":"136","author":"Ohinata","year":"2008","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20180514225542_B41","first-page":"763","article-title":"Principal component analysis for clustering gene expression data","volume":"17","author":"Yeung","year":"2001","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180514225542_B42","first-page":"25","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180514225542_B43","first-page":"1617","article-title":"Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice","volume":"22","author":"Kurimoto","year":"2008","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180514225542_B44","first-page":"D148","article-title":"TFBSshape: a motif database for DNA shape features of transcription factor binding sites","volume":"42","author":"Yang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180514225542_B45","first-page":"384","article-title":"DNA-dependent formation of transcription factor pairs alters their binding specificity","volume":"527","author":"Jolma","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180514225542_B46","first-page":"178","article-title":"Robust in vitro induction of human germ cell fate from pluripotent stem cells","volume":"17","author":"Sasaki","year":"2015","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180514225542_B47","first-page":"1888","article-title":"In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate","volume":"36","author":"Ohta","year":"2017","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180514225542_B48","first-page":"207","article-title":"Blimp1 is a critical determinant of the germ cell lineage in mice","volume":"436","author":"Ohinata","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180514225542_B49","first-page":"1315","article-title":"The zinc finger transcriptional repressor Blimp1\/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse","volume":"132","author":"Vincent","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20180514225542_B50","first-page":"7748","article-title":"A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression","volume":"28","author":"Kim","year":"2008","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20180514225542_B51","first-page":"8237","article-title":"Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development","volume":"41","author":"Kazemian","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180514225542_B52","first-page":"473","article-title":"A transcription factor collective defines cardiac cell fate and reflects lineage history","volume":"148","author":"Junion","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B53","first-page":"798","article-title":"Spurious transcription factor binding: non-functional or genetically redundant","volume":"36","author":"Spivakov","year":"2014","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20180514225542_B54","first-page":"R49","article-title":"Analysis of variation at transcription factor binding sites in Drosophila and humans","volume":"13","author":"Spivakov","year":"2012","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180514225542_B55","first-page":"192","article-title":"Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9","volume":"34","author":"Korkmaz","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20180514225542_B56","first-page":"1545","article-title":"High-resolution interrogation of functional elements in the noncoding genome","volume":"353","author":"Sanjana","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180514225542_B57","first-page":"1530","article-title":"Systematic functional dissection of common genetic variation affecting red blood cell traits","volume":"165","author":"Ulirsch","year":"2016","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180514225542_B58","first-page":"376","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/45\/21\/12152\/24813196\/gkx798.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T22:56:03Z","timestamp":1526338563000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/45\/21\/12152\/4110341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":58,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2017,9,11]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkx798","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"type":"print","value":"0305-1048"},{"type":"electronic","value":"1362-4962"}],"subject":[],"published-other":{"date-parts":[[2017,12,1]]},"published":{"date-parts":[[2017,9,11]]}}}