{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:19:14Z","timestamp":1764587954913,"version":"3.37.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H05670","15H05911","15K14429","16KT0196"],"award-info":[{"award-number":["15H05670","15H05911","15K14429","16KT0196"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ek0410047h0001","18gm6010001h0003","18ek0410041h0002"],"award-info":[{"award-number":["17ek0410047h0001","18gm6010001h0003","18ek0410041h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,14]]},"DOI":"10.1093\/nar\/gky1066","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:41:13Z","timestamp":1540222873000},"page":"11898-11909","source":"Crossref","is-referenced-by-count":41,"title":["Integration of genetics and miRNA\u2013target gene network identified disease biology implicated in tissue specificity"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-9717","authenticated-orcid":false,"given":"Saori","family":"Sakaue","sequence":"first","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"},{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Pharmaceutical Discovery Research Laboratories, TEIJIN PHARMA LIMITED, Hino 191-8512, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan"},{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan"},{"name":"Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology, Tokyo 100-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiryo","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, Medical Sciences Innovation Hub Program (MIH), RIKEN, Yokohama 230-0045, Japan"},{"name":"Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Nii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan"},{"name":"Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan"},{"name":"Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology, Tokyo 100-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-4095","authenticated-orcid":false,"given":"Chikashi","family":"Terao","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"},{"name":"Clinical Research Center, Shizuoka General Hospital, Shizuoka 420-0881, Japan"},{"name":"The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422\u20138526, Japan"},{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"},{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomasa","family":"Suita","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Discovery Technology Research Laboratories, Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd., Tsukuba 300-4247, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Department of Neurology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, National Hospital Organization (NHO) Osaka Minami Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergology, Saiseikai Senri Hospital, Suita 565-0862, Japan"},{"name":"Department of Rheumatology and Allergology, National Hospital Organization (NHO) Osaka Minami Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergology, National Hospital Organization (NHO) Osaka Minami Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Allergology, National Hospital Organization (NHO) Osaka Minami Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Ikari","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women's Medical University, Tokyo 162-0054, Japan"},{"name":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 162-0054, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women's Medical University, Tokyo 162-0054, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women's Medical University, Tokyo 162-0054, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0308","authenticated-orcid":false,"given":"Hideya","family":"Kawaji","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"RIKEN Preventive Medicine and Diagnosis Innovation Program (PMI), Saitama 351-0198, Japan"},{"name":"Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Lassmann","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"Telethon Kids Institute, the University of Western Australia, Western Australia 6008, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"RIKEN Preventive Medicine and Diagnosis Innovation Program (PMI), Saitama 351-0198, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshitomi","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Regeneration, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan"},{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Ohmura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair R","family":"R\u00a0Forrest","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, the University of Western Australia, Western Australia 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Hayashizaki","sequence":"additional","affiliation":[{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"RIKEN Preventive Medicine and Diagnosis Innovation Program (PMI), Saitama 351-0198, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Carninci","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kumanogoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Kamatani","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"},{"name":"Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"de\u00a0Hoon","sequence":"additional","affiliation":[{"name":"Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan"},{"name":"RIKEN Omics Science Center (OSC), Yokohama 230-0045, Japan"},{"name":"Laboratory for Applied Computational Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8472","authenticated-orcid":false,"given":"Yukinori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan"},{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan"},{"name":"Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"key\n\t\t\t\t2018121801541716000_B1","first-page":"D1001","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"Welter","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2018121801541716000_B2","first-page":"7","article-title":"Five years of GWAS discovery","volume":"90","author":"Visscher","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B3","first-page":"124","article-title":"Chromatin marks identify critical cell types for fine mapping complex trait variants","volume":"45","author":"Trynka","year":"2013","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B4","first-page":"1676","article-title":"Estimating the causal tissues for complex traits and diseases","volume":"49","author":"Ongen","year":"2017","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B5","first-page":"10069","article-title":"Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci","volume":"6","author":"Martin","year":"2015","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2018121801541716000_B6","first-page":"S89","article-title":"A short history of a short RNA","volume":"116","author":"Lee","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t2018121801541716000_B7","first-page":"862","article-title":"An extensive class of small RNAs in Caenorhabditis elegans","volume":"294","author":"Lee","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t2018121801541716000_B8","first-page":"834","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018121801541716000_B9","first-page":"242","article-title":"A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease","volume":"43","author":"Brest","year":"2011","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B10","first-page":"685","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018121801541716000_B11","first-page":"1339","article-title":"The race of 10 synthetic RNAi-based drugs to the pharmaceutical market","volume":"34","author":"Titze-de-Almeida","year":"2017","journal-title":"Pharm. Res."},{"key":"key\n\t\t\t\t2018121801541716000_B12","first-page":"872","article-title":"An integrated expression atlas of miRNAs and their promoters in human and mouse","volume":"35","author":"De\u00a0Rie","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t2018121801541716000_B13","first-page":"22223","article-title":"Significant impact of miRNA \u2013 target gene networks on genetics of human complex traits","volume":"6","author":"Okada","year":"2016","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2018121801541716000_B14","first-page":"e1001058","article-title":"Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits","volume":"6","author":"Ayellet","year":"2010","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B15","first-page":"798","article-title":"Construction of a population-specific HLA imputation reference panel and its application to Graves\u2019 disease risk in Japanese","volume":"47","author":"Okada","year":"2015","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B16","first-page":"3865","article-title":"Distribution of miRNA expression across human tissues","volume":"44","author":"Ludwig","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2018121801541716000_B17","first-page":"S2","article-title":"Overview of the BioBank Japan Project: Study design and profile","volume":"27","author":"Nagai","year":"2017","journal-title":"J. Epidemiol."},{"key":"key\n\t\t\t\t2018121801541716000_B18","first-page":"S9","article-title":"Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases","volume":"27","author":"Hirata","year":"2017","journal-title":"J. Epidemiol."},{"key":"key\n\t\t\t\t2018121801541716000_B19","first-page":"2569","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"key\n\t\t\t\t2018121801541716000_B20","first-page":"1120","article-title":"Evaluation of microRNA alignment techniques","volume":"22","author":"Ziemann","year":"2016","journal-title":"RNA"},{"key":"key\n\t\t\t\t2018121801541716000_B21","first-page":"376","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018121801541716000_B22","first-page":"366","article-title":"Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis","volume":"99","author":"Okada","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B23","first-page":"204","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"GTEx Consortium","year":"2017","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018121801541716000_B24","first-page":"228","article-title":"The genetic architecture of gene expression in peripheral blood","volume":"100","author":"Lloyd-Jones","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B25","first-page":"481","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B26","first-page":"861","article-title":"Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set","volume":"61","author":"Kanai","year":"2016","journal-title":"J. Hum. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B27","first-page":"294","article-title":"Estimating missing heritability for disease from genome-wide association studies","volume":"88","author":"Lee","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B28","first-page":"291","article-title":"LD score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B29","first-page":"1173","article-title":"Defining the role of common variation in the genomic and biological architecture of adult human height","volume":"46","author":"Wood","year":"2014","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B30","first-page":"234","article-title":"Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility","volume":"46","author":"DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium","year":"2014","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B31","first-page":"363","article-title":"The cellular and signaling networks linking the immune system and metabolism in disease","volume":"18","author":"Osborn","year":"2012","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t2018121801541716000_B32","first-page":"1228","article-title":"Partitioning heritability by functional annotation using genome-wide association summary statistics","volume":"47","author":"Finucane","year":"2015","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B33","first-page":"1171","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"key\n\t\t\t\t2018121801541716000_B34","first-page":"60","article-title":"The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting","volume":"17","author":"Malmstr\u00f6m","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"key\n\t\t\t\t2018121801541716000_B35","first-page":"1171","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"key\n\t\t\t\t2018121801541716000_B36","first-page":"549","article-title":"MicroRNA-451 Down-Regulates neutrophil Chemotaxis via p38 MAPK","volume":"66","author":"Murata","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"key\n\t\t\t\t2018121801541716000_B37","first-page":"621","article-title":"Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types","volume":"50","author":"Finucane","year":"2018","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2018121801541716000_B38","first-page":"D296","article-title":"miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions","volume":"46","author":"Chou","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/22\/11898\/27179054\/gky1066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T01:54:36Z","timestamp":1545098076000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/22\/11898\/5160971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":38,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2018,11,8]]},"published-print":{"date-parts":[[2018,12,14]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky1066","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"type":"print","value":"0305-1048"},{"type":"electronic","value":"1362-4962"}],"subject":[],"published-other":{"date-parts":[[2018,12,14]]},"published":{"date-parts":[[2018,11,8]]}}}