{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:26:58Z","timestamp":1790742418914,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"12","funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["14171"],"award-info":[{"award-number":["14171"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,6]]},"DOI":"10.1093\/nar\/gky403","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T15:09:09Z","timestamp":1525187349000},"page":"6238-6256","source":"Crossref","is-referenced-by-count":26,"title":["A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair"],"prefix":"10.1093","volume":"46","author":[{"given":"Sanjay Kumar","family":"Bharti","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Sommers","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket","family":"Awate","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A","family":"Bellani","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Khan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Bradley","sequence":"additional","affiliation":[{"name":"Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD\u00a020892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme A","family":"King","sequence":"additional","affiliation":[{"name":"Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD\u00a020892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonee","family":"Seol","sequence":"additional","affiliation":[{"name":"Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD\u00a020892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatasubramanian","family":"Vidhyasagar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Saskatchewan, Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Saskatchewan, Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuye","family":"Abe","sequence":"additional","affiliation":[{"name":"IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Shin-ya","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST) 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitao","sequence":"additional","affiliation":[{"name":"Department of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka\u00a0812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S","family":"Wold","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Branzei","sequence":"additional","affiliation":[{"name":"IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-5671","authenticated-orcid":false,"given":"Keir C","family":"Neuman","sequence":"additional","affiliation":[{"name":"Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD\u00a020892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert M","family":"Brosh","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"key\n\t\t\t\t20180927111253_B1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cell.2014.12.031","article-title":"SnapShot: Fanconi anemia and associated proteins","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180927111253_B2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.blre.2016.10.002","article-title":"Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia","volume":"31","author":"Mamrak","year":"2017","journal-title":"Blood Rev."},{"key":"key\n\t\t\t\t20180927111253_B3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature11863","article-title":"Fanconi anaemia and the repair of Watson and Crick DNA crosslinks","volume":"493","author":"Kottemann","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180927111253_B4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2217\/fon.10.191","article-title":"Hereditary breast cancer and the BRCA1-associated FANCJ\/BACH1\/BRIP1","volume":"7","author":"Cantor","year":"2011","journal-title":"Future Oncol."},{"key":"key\n\t\t\t\t20180927111253_B5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fgene.2014.00372","article-title":"Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia","volume":"5","author":"Brosh","year":"2014","journal-title":"Front. Genet."},{"key":"key\n\t\t\t\t20180927111253_B6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4161\/15384101.2014.987614","article-title":"FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex","volume":"14","author":"Raghunandan","year":"2015","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180927111253_B7","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1128\/MCB.02210-07","article-title":"FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability","volume":"28","author":"Wu","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180927111253_B8","doi-asserted-by":"crossref","first-page":"21699","DOI":"10.1074\/jbc.M112.351338","article-title":"The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B9","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1074\/jbc.M111.287441","article-title":"Repair-specific functions of replication protein A","volume":"287","author":"Hass","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B10","doi-asserted-by":"crossref","first-page":"28217","DOI":"10.1074\/jbc.M113.496463","article-title":"Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability","volume":"288","author":"Bharti","year":"2013","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B11","doi-asserted-by":"crossref","first-page":"25450","DOI":"10.1074\/jbc.M501995200","article-title":"Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer","volume":"280","author":"Gupta","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B12","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1093\/nar\/gkr234","article-title":"Gr resolvase 1 tightly binds and unwinds unimolecular G4-DNA","volume":"39","author":"Giri","year":"2011","journal-title":"Nucl. Acid. Res."},{"key":"key\n\t\t\t\t20180927111253_B13","doi-asserted-by":"crossref","first-page":"e113293","DOI":"10.1371\/journal.pone.0113293","article-title":"Impact of age-associated cyclopurine lesions on DNA repair helicases","volume":"9","author":"Khan","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180927111253_B14","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/blood-2009-11-256016","article-title":"Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes","volume":"116","author":"Wu","year":"2010","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180927111253_B15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ymeth.2016.04.030","article-title":"Single molecule measurements of DNA helicase activity with magnetic tweezers and t-test based step-finding analysis","volume":"105","author":"Seol","year":"2016","journal-title":"Methods (San Diego, Calif.)"},{"key":"key\n\t\t\t\t20180927111253_B16","doi-asserted-by":"crossref","first-page":"E466","DOI":"10.1073\/pnas.1615439114","article-title":"Shuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination","volume":"114","author":"Harami","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180927111253_B17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-1-61779-282-3_15","article-title":"Magnetic tweezers for single-molecule manipulation","volume":"783","author":"Seol","year":"2011","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"key\n\t\t\t\t20180927111253_B18","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1365-2443.2011.01523.x","article-title":"FancJ\/Brip1 helicase protects against genomic losses and gains in vertebrate cells","volume":"16","author":"Kitao","year":"2011","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20180927111253_B19","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1093\/emboj\/19.13.3428","article-title":"Possible association of BLM in decreasing DNA double strand breaks during DNA replication","volume":"19","author":"Wang","year":"2000","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180927111253_B20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/MCB.25.1.34-43.2005","article-title":"Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination","volume":"25","author":"Yamamoto","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180927111253_B21","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nsmb.1504","article-title":"FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway","volume":"15","author":"Ishiai","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20180927111253_B22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/nar\/gkt957","article-title":"Detection of G-quadruplex DNA in mammalian cells","volume":"42","author":"Henderson","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180927111253_B23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/emboj\/17.2.598","article-title":"Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death","volume":"17","author":"Sonoda","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180927111253_B24","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/MCB.01256-12","article-title":"Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response","volume":"33","author":"Suhasini","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180927111253_B25","first-page":"e3255","article-title":"Visualization of DNA replication in the vertebrate model system DT40 using the DNA fiber technique","author":"Schwab","year":"2011","journal-title":"J. Visual. Exp.: JoVE"},{"key":"key\n\t\t\t\t20180927111253_B26","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1182\/blood-2012-12-474585","article-title":"Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia","volume":"121","author":"Chandrasekharappa","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180927111253_B27","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/ng1625","article-title":"The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J","volume":"37","author":"Levitus","year":"2005","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180927111253_B28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/emboj.2011.374","article-title":"Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation","volume":"31","author":"Kuper","year":"2012","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180927111253_B29","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1182\/blood-2006-11-057273","article-title":"FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein","volume":"110","author":"Gupta","year":"2007","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180927111253_B30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0065-3233(08)60411-8","article-title":"Avidin","volume":"29","author":"Green","year":"1975","journal-title":"Adv. Protein Chem."},{"key":"key\n\t\t\t\t20180927111253_B31","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/ng1627","article-title":"The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair","volume":"37","author":"Bridge","year":"2005","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180927111253_B32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0092-8674(81)90426-8","article-title":"New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha","volume":"23","author":"Huberman","year":"1981","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180927111253_B33","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/ja017308q","article-title":"Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex","volume":"124","author":"Kim","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"key\n\t\t\t\t20180927111253_B34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nass\/49.1.235","article-title":"Affinity and selectivity of G4 ligands measured by FRET","author":"De\u00a0Cian","year":"2005","journal-title":"Nucleic Acids Symp. Ser. (Oxf.)"},{"key":"key\n\t\t\t\t20180927111253_B35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1083\/jcb.201208009","article-title":"FANCJ couples replication past natural fork barriers with maintenance of chromatin structure","volume":"201","author":"Schwab","year":"2013","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20180927111253_B36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cell.2011.03.041","article-title":"Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11","volume":"145","author":"Schlacher","year":"2011","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180927111253_B37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ccr.2012.05.015","article-title":"A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1\/2","volume":"22","author":"Schlacher","year":"2012","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20180927111253_B38","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1158\/0008-5472.CAN-11-3417","article-title":"Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1","volume":"72","author":"Ying","year":"2012","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20180927111253_B39","first-page":"305","article-title":"Gamma-H2AX - a novel biomarker for DNA double-strand breaks","volume":"22","author":"Kuo","year":"2008","journal-title":"In vivo (Athens, Greece)"},{"key":"key\n\t\t\t\t20180927111253_B40","doi-asserted-by":"crossref","first-page":"a016410","DOI":"10.1101\/cshperspect.a016410","article-title":"An overview of the molecular mechanisms of recombinational DNA repair","volume":"7","author":"Kowalczykowski","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"key\n\t\t\t\t20180927111253_B41","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1074\/jbc.M809019200","article-title":"FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange","volume":"284","author":"Sommers","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B42","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/emboj.2010.362","article-title":"Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome","volume":"30","author":"Suhasini","year":"2011","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180927111253_B43","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1073\/pnas.96.5.1921","article-title":"Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage","volume":"96","author":"Raderschall","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180927111253_B44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/MCB.25.2.563-574.2005","article-title":"Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures","volume":"25","author":"Zachos","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180927111253_B45","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1007\/s00018-016-2218-x","article-title":"Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway","volume":"73","author":"Lopez-Martinez","year":"2016","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"key\n\t\t\t\t20180927111253_B46","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1073\/pnas.0308717101","article-title":"The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations","volume":"101","author":"Cantor","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180927111253_B47","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1038\/sj.emboj.7601754","article-title":"The FANCJ\/MutLalpha interaction is required for correction of the cross-link response in FA-J cells","volume":"26","author":"Peng","year":"2007","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180927111253_B48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrc1547","article-title":"Bleomycins: towards better therapeutics","volume":"5","author":"Chen","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180927111253_B49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/nar\/gkx1147","article-title":"DNA polymerase beta participates in DNA End-joining","volume":"46","author":"Ray","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180927111253_B50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.1381306","article-title":"Multifactorial contributions to an acute DNA damage response by BRCA1\/BARD1-containing complexes","volume":"20","author":"Greenberg","year":"2006","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180927111253_B51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.molcel.2010.01.002","article-title":"BACH1\/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control","volume":"37","author":"Gong","year":"2010","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180927111253_B52","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nsmb1267","article-title":"Role for BLM in replication-fork restart and suppression of origin firing after replicative stress","volume":"14","author":"Davies","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20180927111253_B53","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mrrev.2012.12.004","article-title":"Disease-causing missense mutations in human DNA helicase disorders","volume":"752","author":"Suhasini","year":"2013","journal-title":"Mut. Res."},{"key":"key\n\t\t\t\t20180927111253_B54","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.M113.538892","article-title":"Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations","volume":"289","author":"Guo","year":"2014","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180927111253_B55","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrd4553","article-title":"Exploiting replicative stress to treat cancer","volume":"14","author":"Dobbelstein","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t20180927111253_B56","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/jcb.22048","article-title":"Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality","volume":"106","author":"Aggarwal","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"key\n\t\t\t\t20180927111253_B57","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrc3560","article-title":"DNA helicases involved in DNA repair and their roles in cancer","volume":"13","author":"Brosh","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180927111253_B58","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/bjc.1996.622","article-title":"Aphidicolin markedly increases the platinum sensitivity of cells from primary ovarian tumours","volume":"74","author":"Sargent","year":"1996","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20180927111253_B59","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/cmdc.201402068","article-title":"Helicases, G4-DNAs, and drug design","volume":"9","author":"Hale","year":"2014","journal-title":"ChemMedChem"},{"key":"key\n\t\t\t\t20180927111253_B60","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.2174\/0929867323666160902153511","article-title":"Noncovalent Binding to DNA: Still a target in developing anticancer agents","volume":"3","author":"Portugal","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"key\n\t\t\t\t20180927111253_B61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/12\/6238\/25844635\/gky403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T04:35:40Z","timestamp":1571286940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/12\/6238\/5000019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,5,21]]},"published-print":{"date-parts":[[2018,7,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky403","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7,6]]},"published":{"date-parts":[[2018,5,21]]}}}