{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:25:48Z","timestamp":1788884748156,"version":"build-2803163510"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM052347"],"award-info":[{"award-number":["GM052347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM103533"],"award-info":[{"award-number":["GM103533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1256082"],"award-info":[{"award-number":["DGE-1256082"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,6]]},"DOI":"10.1093\/nar\/gky623","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T03:12:22Z","timestamp":1530673942000},"page":"7831-7843","source":"Crossref","is-referenced-by-count":30,"title":["Conditional accumulation of toxic tRNAs to cause amino acid misincorporation"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-120X","authenticated-orcid":false,"given":"Stephanie M","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Kon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alayna C","family":"Hauke","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Y","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"},{"name":"Department of Medicine, University of Washington, Seattle, WA 98195, USA"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M","family":"Phizicky","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"key\n\t\t\t\t20180906031309_B1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","author":"Sonenberg","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180906031309_B2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.micro.091208.073210","article-title":"Aminoacyl-tRNA synthesis and translational quality control","volume":"63","author":"Ling","year":"2009","journal-title":"Annu. Rev. Microbiol."},{"key":"key\n\t\t\t\t20180906031309_B3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1097-2765(04)00005-X","article-title":"Kinetic determinants of high-fidelity tRNA discrimination on the ribosome","volume":"13","author":"Gromadski","year":"2004","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180906031309_B4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molcel.2005.12.018","article-title":"A uniform response to mismatches in codon\u2013anticodon complexes ensures ribosomal fidelity","volume":"21","author":"Gromadski","year":"2006","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180906031309_B5","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1098\/rstb.2011.0138","article-title":"Evolutionary optimization of speed and accuracy of decoding on the ribosome","volume":"366","author":"Wohlgemuth","year":"2011","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"key\n\t\t\t\t20180906031309_B6","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1093\/nar\/26.22.5017","article-title":"Universal rules and idiosyncratic features in tRNA identity","volume":"26","author":"Giege","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nsb0994-580","article-title":"A single methyl group prevents the mischarging of a tRNA","volume":"1","author":"Putz","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"key\n\t\t\t\t20180906031309_B8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/336179a0","article-title":"Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification","volume":"336","author":"Muramatsu","year":"1988","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031309_B9","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1093\/nar\/22.23.5031","article-title":"Histidylation by yeast HisRS of tRNA or tRNA-like structure relies on residues -1 and 73 but is dependent on the RNA context","volume":"22","author":"Rudinger","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/nar\/23.3.389","article-title":"Identity elements of Saccharomyces cerevisiae tRNA(His)","volume":"23","author":"Nameki","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B11","doi-asserted-by":"crossref","first-page":"19223","DOI":"10.1073\/pnas.0809336105","article-title":"CP1-dependent partitioning of pretransfer and posttransfer editing in leucyl-tRNA synthetase","volume":"105","author":"Boniecki","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B12","doi-asserted-by":"crossref","first-page":"18510","DOI":"10.1021\/ja2048122","article-title":"Amino-acid-dependent shift in tRNA synthetase editing mechanisms","volume":"133","author":"Sarkar","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"key\n\t\t\t\t20180906031309_B13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/wrna.122","article-title":"Quality control in tRNA charging","volume":"3","author":"Jakubowski","year":"2012","journal-title":"Wiley Interdiscipl. Rev. RNA"},{"key":"key\n\t\t\t\t20180906031309_B14","doi-asserted-by":"crossref","first-page":"15422","DOI":"10.1073\/pnas.2136934100","article-title":"Trans-editing of mischarged tRNAs","volume":"100","author":"Ahel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B15","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nsmb866","article-title":"Structure of a purine-purine wobble base pair in the decoding center of the ribosome","volume":"11","author":"Murphy","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2006.11.014","article-title":"Codon reading by tRNAAla with modified uridine in the wobble position","volume":"25","author":"Kothe","year":"2007","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180906031309_B17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nature10913","article-title":"A new understanding of the decoding principle on the ribosome","volume":"484","author":"Demeshkina","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031309_B18","doi-asserted-by":"crossref","first-page":"10457","DOI":"10.1038\/ncomms10457","article-title":"Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code","volume":"7","author":"Rozov","year":"2016","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180906031309_B19","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1038\/ncomms8251","article-title":"Structural insights into the translational infidelity mechanism","volume":"6","author":"Rozov","year":"2015","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180906031309_B20","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1111408","article-title":"An active role for tRNA in decoding beyond codon:anticodon pairing","volume":"308","author":"Cochella","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20180906031309_B21","doi-asserted-by":"crossref","first-page":"17570","DOI":"10.1073\/pnas.1420196111","article-title":"Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy","volume":"111","author":"Liu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","article-title":"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration","volume":"443","author":"Lee","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031309_B23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1086\/375039","article-title":"Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V","volume":"72","author":"Antonellis","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20180906031309_B24","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1093\/hmg\/ddx231","article-title":"Emerging mechanisms of aminoacyl-tRNA synthetase mutations in recessive and dominant human disease","volume":"26","author":"Meyer-Schuman","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20180906031309_B25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/jmbi.1998.1976","article-title":"Missense translation errors in Saccharomyces cerevisiae","volume":"282","author":"Stansfield","year":"1998","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1261\/rna.294907","article-title":"The frequency of translational misreading errors in E. coli is largely determined by tRNA competition","volume":"13","author":"Kramer","year":"2007","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B27","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1261\/rna.2201210","article-title":"A comprehensive analysis of translational missense errors in the yeast Saccharomyces cerevisiae","volume":"16","author":"Kramer","year":"2010","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg2662","article-title":"The evolutionary consequences of erroneous protein synthesis","volume":"10","author":"Drummond","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20180906031309_B29","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.chembiol.2006.08.011","article-title":"Global effects of mistranslation from an editing defect in mammalian cells","volume":"13","author":"Nangle","year":"2006","journal-title":"Chem. Biol."},{"key":"key\n\t\t\t\t20180906031309_B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15476286.2018.1454244","article-title":"Codon misreading tRNAs promote tumor growth in mice","author":"Santos","year":"2018","journal-title":"RNA Biol."},{"key":"key\n\t\t\t\t20180906031309_B31","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1073\/pnas.0809179105","article-title":"Quality control despite mistranslation caused by an ambiguous genetic code","volume":"105","author":"Ruan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/j.1460-2075.1993.tb05693.x","article-title":"Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5\u2032-CAG-3\u2032 (leucine) anticodon","volume":"12","author":"Santos","year":"1993","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180906031309_B33","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/nar\/23.9.1481","article-title":"The CUG codon is decoded in vivo as serine and not leucine in Candida albicans","volume":"23","author":"Santos","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B34","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1101\/gr.811003","article-title":"Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp","volume":"13","author":"Massey","year":"2003","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180906031309_B35","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/gb-2007-8-10-r206","article-title":"A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans","volume":"8","author":"Gomes","year":"2007","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20180906031309_B36","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1073\/pnas.1317580111","article-title":"Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance","volume":"111","author":"Javid","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B37","doi-asserted-by":"crossref","first-page":"9378","DOI":"10.1073\/pnas.1016460108","article-title":"Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B38","doi-asserted-by":"crossref","first-page":"11543","DOI":"10.1073\/pnas.0912989107","article-title":"Visualizing high error levels during gene expression in living bacterial cells","volume":"107","author":"Meyerovich","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B39","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/acschembio.7b00974","article-title":"Playing with the molecules of life","volume":"13","author":"Young","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"key\n\t\t\t\t20180906031309_B40","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1101\/gad.1018902","article-title":"Recruitment of RNA polymerase III to its target promoters","volume":"16","author":"Schramm","year":"2002","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180906031309_B41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1146\/annurev.bi.57.070188.004301","article-title":"Transcription by RNA polymerase III","volume":"57","author":"Geiduschek","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20180906031309_B42","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/nar\/gkl085","article-title":"The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications","volume":"34","author":"Marck","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.molcel.2005.10.036","article-title":"Rapid tRNA decay can result from lack of nonessential modifications","volume":"21","author":"Alexandrov","year":"2006","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180906031309_B44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1261\/rna.811008","article-title":"Identification of yeast tRNA Um(44) 2\u2032-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species","volume":"14","author":"Kotelawala","year":"2008","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B45","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1101\/gad.1654308","article-title":"Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5\u2032-3\u2032 exonucleases Rat1 and Xrn1","volume":"22","author":"Chernyakov","year":"2008","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180906031309_B46","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1261\/rna.033654.112","article-title":"The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications","volume":"18","author":"Dewe","year":"2012","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B47","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.2050711","article-title":"The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA","volume":"25","author":"Whipple","year":"2011","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180906031309_B48","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1101\/gad.245936.114","article-title":"Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis","volume":"28","author":"Guy","year":"2014","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20180906031309_B49","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1261\/rna.064642.117","article-title":"Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA","volume":"24","author":"Payea","year":"2018","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B50","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/yea.1142","article-title":"A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes","volume":"21","author":"Janke","year":"2004","journal-title":"Yeast"},{"key":"key\n\t\t\t\t20180906031309_B51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2007.13","article-title":"High-efficiency yeast transformation using the LiAc\/SS carrier DNA\/PEG method","volume":"2","author":"Gietz","year":"2007","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20180906031309_B52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180906031309_B53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature02046","article-title":"Global analysis of protein expression in yeast","volume":"425","author":"Ghaemmaghami","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031309_B54","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1128\/MCB.01542-07","article-title":"Eukaryotic wobble uridine modifications promote a functionally redundant decoding system","volume":"28","author":"Johansson","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180906031309_B55","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20180906031309_B56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pmic.201200439","article-title":"Comet: an open-source MS\/MS sequence database search tool","volume":"13","author":"Eng","year":"2013","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180906031309_B57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry","volume":"4","author":"Elias","year":"2007","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180906031309_B58","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"Kall","year":"2007","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180906031309_B59","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s13361-015-1179-x","article-title":"A deeper look into Comet\u2013implementation and features","volume":"26","author":"Eng","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"key\n\t\t\t\t20180906031309_B60","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1006\/jmbi.1997.0991","article-title":"Only one nucleotide insertion to the long variable arm confers an efficient serine acceptor activity upon Saccharomyces cerevisiae tRNA(Leu) in vitro","volume":"268","author":"Himeno","year":"1997","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B61","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/nar\/gkg306","article-title":"Revisiting the codon adaptation index from a whole-genome perspective: analyzing the relationship between gene expression and codon occurrence in yeast using a variety of models","volume":"31","author":"Jansen","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B62","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1073\/pnas.89.22.10915","article-title":"Amino acid substitution matrices from protein blocks","volume":"89","author":"Henikoff","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B63","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1261\/rna.5142404","article-title":"Purine bases at position 37 of tRNA stabilize codon\u2013anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions","volume":"10","author":"Konevega","year":"2004","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B64","doi-asserted-by":"crossref","first-page":"D184","DOI":"10.1093\/nar\/gkv1309","article-title":"GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes","volume":"44","author":"Chan","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B65","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/j.1460-2075.1996.tb00886.x","article-title":"Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans","volume":"15","author":"Santos","year":"1996","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20180906031309_B66","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1017\/S1355838202022021","article-title":"tRNomics: analysis of tRNA genes from 50 genomes of Eukarya, Archaea, and Bacteria reveals anticodon-sparing strategies and domain-specific features","volume":"8","author":"Marck","year":"2002","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/jmbi.1995.0200","article-title":"Identification of base-triples in RNA using comparative sequence analysis","volume":"248","author":"Gautheret","year":"1995","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B68","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1128\/JB.156.2.625-635.1983","article-title":"The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of Saccharomyces cerevisiae is responsible for curing and high copy number","volume":"156","author":"Erhart","year":"1983","journal-title":"J. Bacteriol."},{"key":"key\n\t\t\t\t20180906031309_B69","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1261\/rna.2411710","article-title":"Control of translation efficiency in yeast by codon\u2013anticodon interactions","volume":"16","author":"Letzring","year":"2010","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B70","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/nar\/23.15.2831","article-title":"Identity elements of tRNA(Thr) towards Saccharomyces cerevisiae threonyl-tRNA synthetase","volume":"23","author":"Nameki","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B71","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/bi992276t","article-title":"Identity of tRNA for yeast tyrosyl-tRNA synthetase: tyrosylation is more sensitive to identity nucleotides than to structural features","volume":"39","author":"Fechter","year":"2000","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180906031309_B72","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/nsmb861","article-title":"The role of modifications in codon discrimination by tRNA(Lys)UUU","volume":"11","author":"Murphy","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2006.11.046","article-title":"tRNA\u2019s wobble decoding of the genome: 40 years of modification","volume":"366","author":"Agris","year":"2007","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B74","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1261\/rna.059667.116","article-title":"S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates","volume":"23","author":"Han","year":"2017","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B75","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1261\/rna.056259.116","article-title":"Evolving specificity of tRNA 3-methyl-cytidine-32 (m3C32) modification: a subset of tRNAsSer requires N6-isopentenylation of A37","volume":"22","author":"Arimbasseri","year":"2016","journal-title":"RNA"},{"key":"key\n\t\t\t\t20180906031309_B76","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1126\/science.1057718","article-title":"Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway","volume":"292","author":"Doring","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20180906031309_B77","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1021\/acs.biochem.8b00177","article-title":"Mapping the plasticity of the escherichia coli genetic code with orthogonal Pair-Directed sense codon reassignment","volume":"57","author":"Schmitt","year":"2018","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20180906031309_B78","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature08576","article-title":"Innate immune and chemically triggered oxidative stress modifies translational fidelity","volume":"462","author":"Netzer","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031309_B79","doi-asserted-by":"crossref","first-page":"11079","DOI":"10.1073\/pnas.1302094110","article-title":"Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification","volume":"110","author":"Bezerra","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031309_B80","doi-asserted-by":"crossref","first-page":"e00167-17","DOI":"10.1128\/mSphere.00167-17","article-title":"Adaptive mistranslation accelerates the evolution of fluconazole resistance and induces major genomic and gene expression alterations in candida albicans","volume":"2","author":"Weil","year":"2017","journal-title":"mSphere"},{"key":"key\n\t\t\t\t20180906031309_B81","doi-asserted-by":"crossref","first-page":"15410","DOI":"10.1038\/ncomms15410","article-title":"Mistranslation can enhance fitness through purging of deleterious mutations","volume":"8","author":"Bratulic","year":"2017","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t20180906031309_B82","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/nar\/gkv1379","article-title":"Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures","volume":"44","author":"Schwartz","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B83","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/nar\/gkw1021","article-title":"Genetic selection for mistranslation rescues a defective co-chaperone in yeast","volume":"45","author":"Hoffman","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B84","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1101\/gr.200931.115","article-title":"A novel nuclear genetic code alteration in yeasts and the evolution of codon reassignment in eukaryotes","volume":"26","author":"Muhlhausen","year":"2016","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20180906031309_B85","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1006\/jmbi.1994.1094","article-title":"Transfer RNA mutation and the malleability of the genetic code","volume":"235","author":"Schultz","year":"1994","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20180906031309_B86","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1534\/genetics.117.203232","article-title":"Evolving mistranslating tRNAs through a phenotypically ambivalent intermediate in saccharomyces cerevisiae","volume":"206","author":"Berg","year":"2017","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20180906031309_B87","doi-asserted-by":"crossref","first-page":"e1002291","DOI":"10.1371\/journal.pbio.1002291","article-title":"Evolution of robustness to protein mistranslation by accelerated protein turnover","volume":"13","author":"Kalapis","year":"2015","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20180906031309_B88","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1093\/nar\/gkp1083","article-title":"Chimeric tRNAs as tools to induce proteome damage and identify components of stress responses","volume":"38","author":"Geslain","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031309_B89","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1126\/science.aae0568","article-title":"The fitness landscape of a tRNA gene","volume":"352","author":"Li","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180906031309_B90","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbrc.2012.09.028","article-title":"Anti-tumor effects of an engineered \u2018killer\u2019 transfer RNA","volume":"427","author":"Zhou","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/15\/7831\/25690140\/gky623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T02:00:36Z","timestamp":1604541636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/15\/7831\/5051837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":90,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2018,7,11]]},"published-print":{"date-parts":[[2018,9,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky623","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9,6]]},"published":{"date-parts":[[2018,7,11]]}}}