{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:38:11Z","timestamp":1790807891326,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,6]]},"DOI":"10.1093\/nar\/gky634","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T17:42:25Z","timestamp":1531590145000},"page":"7844-7857","source":"Crossref","is-referenced-by-count":43,"title":["Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation\/phosphorylation of ELAVL1\/HuR"],"prefix":"10.1093","volume":"46","author":[{"given":"Shyue-Fang","family":"Battaglia-Hsu","sequence":"first","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Ghemrawi","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Coelho","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Dreumont","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mosca","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hergalant","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gauchotte","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, SUNY-Downstate Medical Center, Brooklyn, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Ndiongue","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Houlgatte","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Alberto","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Umoret","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Robert","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Paoli","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Saarland University, Building 44, Homburg 66421, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V","family":"Quadros","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, SUNY-Downstate Medical Center, Brooklyn, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Gu\u00e9ant","sequence":"additional","affiliation":[{"name":"INSERM UMRS 954 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure and National Center of Inborn Errors of Metabolism, Faculty of Medicine of Nancy, University of Lorraine and University Regional Hospital Center of Nancy, Vandoeuvre-l\u00e8s-Nancy, F-54000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"key\n\t\t\t\t20180906031337_B1","first-page":"1019","article-title":"Lessons in biology from patients with inborn errors of vitamin B12 metabolism","volume":"95","author":"Watkins","year":"2013","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20180906031337_B2","first-page":"1033","article-title":"Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase","volume":"95","author":"Gueant","year":"2013","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20180906031337_B3","first-page":"41","article-title":"Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR\/CD320 knockout mouse","volume":"9","author":"Fernandez-Roig","year":"2012","journal-title":"Nutr. Metab. (Lond.)"},{"key":"key\n\t\t\t\t20180906031337_B4","first-page":"1008","article-title":"Cellular uptake of cobalamin: transcobalamin and the TCblR\/CD320 receptor","volume":"95","author":"Quadros","year":"2013","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20180906031337_B5","first-page":"e553","article-title":"Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1","volume":"4","author":"Ghemrawi","year":"2013","journal-title":"Cell Death Dis."},{"key":"key\n\t\t\t\t20180906031337_B6","first-page":"2468","article-title":"The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system","volume":"27","author":"Lai","year":"2013","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20180906031337_B7","first-page":"e6325","article-title":"Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin","volume":"4","author":"Pons","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180906031337_B8","first-page":"21930","article-title":"Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE","volume":"106","author":"Battaglia-Hsu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031337_B9","first-page":"81","article-title":"Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development","volume":"155","author":"Padmanabhan","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180906031337_B10","first-page":"324","article-title":"Methyl donor deficiency induces cardiomyopathy through altered methylation\/acetylation of PGC-1alpha by PRMT1 and SIRT1","volume":"225","author":"Garcia","year":"2011","journal-title":"J. Pathol."},{"key":"key\n\t\t\t\t20180906031337_B11","first-page":"344","article-title":"Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver","volume":"57","author":"Pooya","year":"2012","journal-title":"J. Hepatol."},{"key":"key\n\t\t\t\t20180906031337_B12","first-page":"833","article-title":"Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart","volume":"466","author":"Gueant","year":"2014","journal-title":"Pflugers Arch."},{"key":"key\n\t\t\t\t20180906031337_B13","first-page":"279","article-title":"Folate and fetal programming: a play in epigenomics","volume":"24","author":"Gueant","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"key\n\t\t\t\t20180906031337_B14","first-page":"3713","article-title":"Folate- and vitamin B12-deficient diet during gestation and lactation alters cerebellar synapsin expression via impaired influence of estrogen nuclear receptor alpha","volume":"29","author":"Pourie","year":"2015","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20180906031337_B15","first-page":"477","article-title":"Proteomics of vitamin B12 processing","volume":"51","author":"Hannibal","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"key\n\t\t\t\t20180906031337_B16","first-page":"2385","article-title":"RBM45 modulates the antioxidant response in amyotrophic lateral sclerosis through interactions with KEAP1","volume":"35","author":"Bakkar","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180906031337_B17","first-page":"226","article-title":"RNA-binding proteins in neurodegeneration: Seq and you shall receive","volume":"38","author":"Nussbacher","year":"2015","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20180906031337_B18","first-page":"3621","article-title":"The function of RNA-binding proteins at the synapse: implications for neurodegeneration","volume":"72","author":"Sephton","year":"2015","journal-title":"Cell Mol. Life Sci."},{"key":"key\n\t\t\t\t20180906031337_B19","first-page":"15","article-title":"Loss of CARM1 is linked to reduced ELAVL1\/HuR function in replicative senescence","volume":"14","author":"Pang","year":"2013","journal-title":"BMC Mol. Biol."},{"key":"key\n\t\t\t\t20180906031337_B20","first-page":"e1372","article-title":"Posttranslational control of ELAVL1\/HuR function","volume":"8","author":"Grammatikakis","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"key\n\t\t\t\t20180906031337_B21","first-page":"4591","article-title":"Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia","volume":"22","author":"Fofou-Caillierez","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20180906031337_B22","first-page":"293","article-title":"Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver disease","volume":"59","author":"Chen","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"key\n\t\t\t\t20180906031337_B23","first-page":"3201","article-title":"Hyper conserved elements in vertebrate mRNA 3\u2032-UTRs reveal a translational network of RNA-binding proteins controlled by ELAVL1\/HuR","volume":"41","author":"Dassi","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20180906031337_B24","first-page":"365","article-title":"Postage for the messenger: designating routes for nuclear mRNA export","volume":"23","author":"Natalizio","year":"2013","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20180906031337_B25","first-page":"44623","article-title":"Lipopolysaccharide-induced methylation of ELAVL1\/HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase","volume":"277","author":"Li","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180906031337_B26","first-page":"467","article-title":"Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with ELAVL1\/HuR and PP2A","volume":"453","author":"Hyvonen","year":"2013","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20180906031337_B27","first-page":"4508","article-title":"Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus","volume":"186","author":"Sunahori","year":"2011","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180906031337_B28","first-page":"380","article-title":"Regulation of the mRNA-binding protein ELAVL1\/HuR by posttranslational modification: spotlight on phosphorylation","volume":"13","author":"Eberhardt","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"key\n\t\t\t\t20180906031337_B29","first-page":"15293","article-title":"HNS, a nuclear-cytoplasmic shuttling sequence in ELAVL1\/HuR","volume":"95","author":"Fan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031337_B30","first-page":"3605","article-title":"Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock","volume":"102","author":"Allemand","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031337_B31","first-page":"595","article-title":"Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress","volume":"65","author":"Melhem","year":"2016","journal-title":"Gut"},{"key":"key\n\t\t\t\t20180906031337_B32","first-page":"1063","article-title":"Stress- inducible regulation of heat shock factor 1 by the deacetylase SIRT1","volume":"323","author":"Westerheide","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20180906031337_B33","first-page":"1","article-title":"Protein ligands to HuR modulate its interaction with target mRNAs in vivo","volume":"151","author":"Brennan","year":"2000","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20180906031337_B34","first-page":"310","article-title":"Anp32e (Cpd1) and related protein phosphatase 2 inhibitors","volume":"2","author":"Santa-Coloma","year":"2003","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180906031337_B35","first-page":"15","article-title":"Loss of CARM1 is linked to reduced HuR function in replicative senescence","volume":"14","author":"Pang","year":"2013","journal-title":"BMC Mol. Biol."},{"key":"key\n\t\t\t\t20180906031337_B36","first-page":"13736","article-title":"Sirtuin 1 regulation of developmental genes during differentiation of stem cells","volume":"107","author":"Calvanese","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031337_B37","first-page":"1192","article-title":"One-carbon metabolism and Alzheimer's disease: is it all a methylation matter","volume":"32","author":"Fuso","year":"2011","journal-title":"Neurobiol. Aging."},{"key":"key\n\t\t\t\t20180906031337_B38","first-page":"236","article-title":"RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration","volume":"518","author":"Peretti","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180906031337_B39","first-page":"703","article-title":"Neuroprotection requires the functions of the RNA-binding protein HuR","volume":"22","author":"Skliris","year":"2015","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20180906031337_B40","first-page":"77","article-title":"AsSIRTing the DNA damage response","volume":"18","author":"Gorospe","year":"2008","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20180906031337_B41","first-page":"1288","article-title":"Posttranscriptional orchestration of an anti-apoptotic program by HuR","volume":"6","author":"Abdelmohsen","year":"2007","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180906031337_B42","first-page":"E3815","article-title":"Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R","volume":"111","author":"Kraushar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180906031337_B43","first-page":"273","article-title":"Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression","volume":"61","author":"Antic","year":"1997","journal-title":"Am. J. Hum. Genet."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/15\/7844\/25690324\/gky634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T07:14:48Z","timestamp":1536218088000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/15\/7844\/5054864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":43,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2018,7,17]]},"published-print":{"date-parts":[[2018,9,6]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky634","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9,6]]},"published":{"date-parts":[[2018,7,17]]}}}