{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:19:36Z","timestamp":1780629576368,"version":"3.54.1"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH P01 HL-51670"],"award-info":[{"award-number":["NIH P01 HL-51670"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH P01 HL-091842"],"award-info":[{"award-number":["NIH P01 HL-091842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL-133089"],"award-info":[{"award-number":["NIH R01 HL-133089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL-105821"],"award-info":[{"award-number":["NIH R01 HL-105821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Gene Therapy of Cystic Fibrosis","award":["P30 DK-054759"],"award-info":[{"award-number":["P30 DK-054759"]}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["SINN15XX0"],"award-info":[{"award-number":["SINN15XX0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,12]]},"DOI":"10.1093\/nar\/gky773","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T03:56:46Z","timestamp":1534996606000},"page":"9591-9600","source":"Crossref","is-referenced-by-count":45,"title":["Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac\/adenovirus"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-9138","authenticated-orcid":false,"given":"Ashley L","family":"Cooney","sequence":"first","affiliation":[{"name":"Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brajesh K","family":"Singh","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Marquez","family":"Loza","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Molecular Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Thornell","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla E","family":"Hippee","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"Powers","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda S","family":"Ostedgaard","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K","family":"Meyerholz","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Pathology, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Wohlford-Lenane","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Stoltz","sequence":"additional","affiliation":[{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Pathology, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul","family":"B.\u00a0McCray","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Molecular Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L","family":"Sinn","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA"},{"name":"Pappajohn Biomedical Institute and the Center for Gene Therapy for Cystic Fibrosis, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"key\n\t\t\t\t20181012020253135_B1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11130","article-title":"Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung","volume":"487","author":"Pezzulo","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181012020253135_B2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1172\/JCI83922","article-title":"Acidic pH increases airway surface liquid viscosity in cystic fibrosis","volume":"126","author":"Tang","year":"2016","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20181012020253135_B3","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMoa1105185","article-title":"A CFTR potentiator in patients with cystic fibrosis and the G551D mutation","volume":"365","author":"Ramsey","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20181012020253135_B4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/thoraxjnl-2011-200393","article-title":"Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation","volume":"67","author":"Clancy","year":"2012","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20181012020253135_B5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1056\/NEJMoa1409547","article-title":"Lumacaftor-Ivacaftor in patients with cystic fibrosis homozygous for Phe508del CFTR","volume":"373","author":"Wainwright","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20181012020253135_B6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMra1300109","article-title":"Origins of cystic fibrosis lung disease","volume":"372","author":"Stoltz","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20181012020253135_B7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/thx.2010.139493","article-title":"Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis","volume":"66","author":"Ranganathan","year":"2011","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20181012020253135_B8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biocel.2014.01.017","article-title":"Current concepts of immune dysregulation in cystic fibrosis","volume":"52","author":"Rieber","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20181012020253135_B9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ppul.21154","article-title":"Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively","volume":"45","author":"Tiddens","year":"2010","journal-title":"Pediatr. Pulmonol."},{"key":"key\n\t\t\t\t20181012020253135_B10","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/ppul.20294","article-title":"Lower airway inflammation in infants with cystic fibrosis detected by newborn screening","volume":"40","author":"Armstrong","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"key\n\t\t\t\t20181012020253135_B11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jpeds.2003.09.026","article-title":"Structural airway abnormalities in infants and young children with cystic fibrosis","volume":"144","author":"Long","year":"2004","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20181012020253135_B12","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1164\/rccm.200412-1665OC","article-title":"High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis","volume":"172","author":"Martinez","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"key\n\t\t\t\t20181012020253135_B13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jpeds.2009.05.005","article-title":"Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening","volume":"155","author":"Stick","year":"2009","journal-title":"J. Pediatr."},{"key":"key\n\t\t\t\t20181012020253135_B14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/mt.2014.254","article-title":"Hybrid nonviral\/viral vector systems for improved piggyBac DNA transposon in vivo delivery","volume":"23","author":"Cooney","year":"2015","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/nbt738","article-title":"Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo","volume":"20","author":"Yant","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20181012020253135_B16","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/mt.2010.169","article-title":"Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B","volume":"18","author":"Hausl","year":"2010","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2174\/156652311797415890","article-title":"Development of adenovirus hybrid vectors for Sleeping Beauty transposition in large mammals","volume":"11","author":"Hausl","year":"2011","journal-title":"Curr. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2583.1996.tb00048.x","article-title":"Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of Lepidoptera","volume":"5","author":"Fraser","year":"1996","journal-title":"Insect Mol. Biol."},{"key":"key\n\t\t\t\t20181012020253135_B19","first-page":"149","article-title":"Development of a porcine model of cystic fibrosis","volume":"120","author":"Welsh","year":"2009","journal-title":"Trans. Am. Clin. Climatol Assoc."},{"key":"key\n\t\t\t\t20181012020253135_B20","doi-asserted-by":"crossref","first-page":"29ra31","DOI":"10.1126\/scitranslmed.3000928","article-title":"Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth","volume":"2","author":"Stoltz","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20181012020253135_B21","doi-asserted-by":"crossref","first-page":"74ra24","DOI":"10.1126\/scitranslmed.3001868","article-title":"The {Delta}F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs","volume":"3","author":"Ostedgaard","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t20181012020253135_B22","doi-asserted-by":"crossref","first-page":"e88730","DOI":"10.1172\/jci.insight.88730","article-title":"Lentiviral-mediated phenotypic correction of cystic fibrosis pigs","volume":"1","author":"Cooney","year":"2016","journal-title":"JCI Insight"},{"key":"key\n\t\t\t\t20181012020253135_B23","doi-asserted-by":"crossref","first-page":"e88728","DOI":"10.1172\/jci.insight.88728","article-title":"CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes","volume":"1","author":"Steines","year":"2016","journal-title":"JCI Insight"},{"key":"key\n\t\t\t\t20181012020253135_B24","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1172\/JCI68867","article-title":"Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs","volume":"123","author":"Stoltz","year":"2013","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20181012020253135_B25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1089\/hum.2015.001","article-title":"Optimization of recombinant Adeno-Associated Virus-Mediated expression for large transgenes, using a synthetic promoter and tandem array enhancers","volume":"26","author":"Yan","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B26","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1126\/science.1163600","article-title":"Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs","volume":"321","author":"Rogers","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20181012020253135_B27","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1089\/hum.1998.9.18-2661","article-title":"Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent","volume":"9","author":"Parsons","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cell.2010.11.029","article-title":"Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia","volume":"143","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181012020253135_B29","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1091\/mbc.e04-11-1010","article-title":"Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia","volume":"16","author":"Kreda","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20181012020253135_B30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1053\/j.gastro.2003.10.049","article-title":"The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon","volume":"126","author":"Mall","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20181012020253135_B31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/0192623315609691","article-title":"Immunohistochemical detection of markers for translational studies of lung disease in pigs and humans","volume":"44","author":"Meyerholz","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20181012020253135_B32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2199-8-67","article-title":"Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR","volume":"8","author":"Nygard","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"key\n\t\t\t\t20181012020253135_B33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1172\/JCI0215780","article-title":"Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins","volume":"110","author":"Auricchio","year":"2002","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20181012020253135_B34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1165\/ajrcmb.12.4.7695917","article-title":"Polarity of secretion of alpha 1-antitrypsin by human respiratory epithelial cells after adenoviral transfer of a human alpha 1-antitrypsin cDNA","volume":"12","author":"Siegfried","year":"1995","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20181012020253135_B35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1172\/JCI0216443","article-title":"The lung as a metabolic factory for gene therapy","volume":"110","author":"Engelhardt","year":"2002","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20181012020253135_B36","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1038\/mtna.2013.55","article-title":"Efficient gene delivery to pig airway epithelia and submucosal glands using helper-dependent adenoviral vectors","volume":"2","author":"Cao","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"key\n\t\t\t\t20181012020253135_B37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.omtm.2016.11.002","article-title":"INSPIIRED: a pipeline for quantitative analysis of sites of new DNA integration in cellular genomes","volume":"4","author":"Sherman","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"key\n\t\t\t\t20181012020253135_B38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.omtm.2016.11.003","article-title":"INSPIIRED: quantification and visualization tools for analyzing integration site distributions","volume":"4","author":"Berry","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"key\n\t\t\t\t20181012020253135_B39","doi-asserted-by":"crossref","first-page":"E2279","DOI":"10.1073\/pnas.1305987110","article-title":"piggyBac transposase tools for genome engineering","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20181012020253135_B40","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng1192-240","article-title":"Submucosal glands are the predominant site of CFTR expression in the human bronchus","volume":"2","author":"Engelhardt","year":"1992","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20181012020253135_B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/gt.2013.52","article-title":"Minimal piggyBac vectors for chromatin integration","volume":"21","author":"Solodushko","year":"2014","journal-title":"Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/hum.2013.2527","article-title":"Adenovirus: the first effective in vivo gene delivery vector","volume":"25","author":"Crystal","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B43","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1089\/104303401750298535","article-title":"Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications","volume":"12","author":"Joseph","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B44","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1089\/104303401750298544","article-title":"Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium","volume":"12","author":"Perricone","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B45","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20181012020253135_B46","doi-asserted-by":"crossref","first-page":"10219","DOI":"10.1074\/jbc.274.15.10219","article-title":"Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia","volume":"274","author":"Walters","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20181012020253135_B47","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/104303401300042348","article-title":"EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo","volume":"12","author":"Chu","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1165\/ajrcmb.22.2.3938","article-title":"Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo","volume":"22","author":"Wang","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"key\n\t\t\t\t20181012020253135_B49","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1089\/hum.1998.9.10-1469","article-title":"Potentiation of gene transfer to the mouse lung by complexes of adenovirus vector and polycations improves therapeutic potential","volume":"9","author":"Kaplan","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B50","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1073\/pnas.91.10.4407","article-title":"Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy","volume":"91","author":"Yang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20181012020253135_B51","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1089\/hum.1997.8.14-1675","article-title":"Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract","volume":"8","author":"Worgall","year":"1997","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2007.10.005","article-title":"Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications","volume":"132","author":"Hartman","year":"2008","journal-title":"Virus Res."},{"key":"key\n\t\t\t\t20181012020253135_B53","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/mt.2009.177","article-title":"A new link between virus cell entry and inflammation: adenovirus interaction with integrins induces specific proinflammatory responses","volume":"17","author":"Nemerow","year":"2009","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B54","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/jcb.22328","article-title":"The influence of innate and pre-existing immunity on adenovirus therapy","volume":"108","author":"Zaiss","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"key\n\t\t\t\t20181012020253135_B55","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1128\/JVI.70.10.7209-7212.1996","article-title":"Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs","volume":"70","author":"Yang","year":"1996","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20181012020253135_B56","first-page":"412","article-title":"Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver","volume":"3","author":"Yang","year":"1996","journal-title":"Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B57","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1089\/hum.1996.7.18-2273","article-title":"Nondepleting anti-CD4 antibody treatment prolongs lung-directed E1-deleted adenovirus-mediated gene expression in rats","volume":"7","author":"Lei","year":"1996","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B58","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1089\/hum.1998.9.15-2207","article-title":"Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses","volume":"9","author":"Otake","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B59","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1089\/10430349950016384","article-title":"A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis","volume":"10","author":"Zuckerman","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B60","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1182\/blood.V99.2.600","article-title":"Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14(+) monocytes cultured under serum-free conditions","volume":"99","author":"Lyakh","year":"2002","journal-title":"Blood"},{"key":"key\n\t\t\t\t20181012020253135_B61","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1128\/JVI.00740-12","article-title":"Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys","volume":"86","author":"Teigler","year":"2012","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20181012020253135_B62","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1097\/00007890-199610270-00010","article-title":"Adenovirus-mediated gene transfer in the transplant setting: early events after orthotopic transplantation of liver allografts expressing TGF-beta1","volume":"62","author":"Drazan","year":"1996","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t20181012020253135_B63","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1128\/JVI.78.11.5966-5972.2004","article-title":"Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo","volume":"78","author":"Muruve","year":"2004","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20181012020253135_B64","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1128\/JVI.75.10.4792-4801.2001","article-title":"\u201cStealth\u201d adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung","volume":"75","author":"Croyle","year":"2001","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20181012020253135_B65","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1525-0016(03)00059-5","article-title":"Reduced inflammation and improved airway expression using helper-dependent adenoviral vectors with a K18 promoter","volume":"7","author":"Toietta","year":"2003","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B66","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/sj.gt.3302712","article-title":"Readministration of helper-dependent adenovirus to mouse lung","volume":"13","author":"Koehler","year":"2006","journal-title":"Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/gt.2010.125","article-title":"Readministration of helper-dependent adenoviral vectors to mouse airway mediated via transient immunosuppression","volume":"18","author":"Cao","year":"2011","journal-title":"Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B68","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/hum.2017.201","article-title":"Transducing airway basal cells with a helper-dependent adenoviral vector for lung gene therapy","volume":"29","author":"Cao","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20181012020253135_B69","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1","volume":"302","author":"Hacein-Bey-Abina","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20181012020253135_B70","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1172\/JCI35798","article-title":"Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients","volume":"118","author":"Howe","year":"2008","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20181012020253135_B71","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1056\/NEJMoa1003548","article-title":"Stem-cell gene therapy for the Wiskott-Aldrich syndrome","volume":"363","author":"Boztug","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20181012020253135_B72","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm.2088","article-title":"Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease","volume":"16","author":"Stein","year":"2010","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20181012020253135_B73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/mt.2010.305","article-title":"Solving the problem of gamma-retroviral vectors containing long terminal repeats","volume":"19","author":"Persons","year":"2011","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B74","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/mt.2016.11","article-title":"Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells","volume":"24","author":"Gogol-Doring","year":"2016","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20181012020253135_B75","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/CJI.0b013e3181b2914c","article-title":"Genome-wide mapping of PiggyBac transposon integrations in primary human T cells","volume":"32","author":"Galvan","year":"2009","journal-title":"J. Immunother."},{"key":"key\n\t\t\t\t20181012020253135_B76","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/mt.2010.141","article-title":"Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells","volume":"18","author":"Huang","year":"2010","journal-title":"Mol. Ther."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/18\/9591\/26001260\/gky773.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T04:11:08Z","timestamp":1604808668000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/18\/9591\/5079698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":76,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2018,8,27]]},"published-print":{"date-parts":[[2018,10,12]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky773","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10,12]]},"published":{"date-parts":[[2018,8,27]]}}}