{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:50:53Z","timestamp":1790833853495,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR 2010 BLAN 161501"],"award-info":[{"award-number":["ANR 2010 BLAN 161501"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM DEI201512344404"],"award-info":[{"award-number":["FRM DEI201512344404"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006431","name":"Canc\u00e9rop\u00f4le Ile-de-France","doi-asserted-by":"crossref","award":["2009-2-INV-03"],"award-info":[{"award-number":["2009-2-INV-03"]}],"id":[{"id":"10.13039\/501100006431","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15520711500"],"award-info":[{"award-number":["15520711500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,2]]},"DOI":"10.1093\/nar\/gky797","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T15:13:25Z","timestamp":1535123605000},"page":"10157-10172","source":"Crossref","is-referenced-by-count":44,"title":["Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions"],"prefix":"10.1093","volume":"46","author":[{"given":"Xia","family":"Wu","sequence":"first","affiliation":[{"name":"Institut de Biologie de l\u2019\u00c9cole Normale Sup\u00e9rieure (IBENS), D\u00e9partement de Biologie, Ecole Normale Sup\u00e9rieure, CNRS, Inserm, PSL Research University, F-75005 Paris, France"},{"name":"Physics Department, East China Normal University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Kabalane","sequence":"additional","affiliation":[{"name":"Univ Lyon, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS, Laboratoire de Physique, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Kahli","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019\u00c9cole Normale Sup\u00e9rieure (IBENS), D\u00e9partement de Biologie, Ecole Normale Sup\u00e9rieure, CNRS, Inserm, PSL Research University, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Petryk","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019\u00c9cole Normale Sup\u00e9rieure (IBENS), D\u00e9partement de Biologie, Ecole Normale Sup\u00e9rieure, CNRS, Inserm, PSL Research University, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Laperrousaz","sequence":"additional","affiliation":[{"name":"Univ Lyon, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS, Laboratoire de Physique, F-69342 Lyon, France"},{"name":"CNRS UMR5286, INSERM U1052, Centre de Recherche en Canc\u00e9rologie de Lyon, F- 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jaszczyszyn","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenola","family":"Drillon","sequence":"additional","affiliation":[{"name":"Univ Lyon, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS, Laboratoire de Physique, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank-Emmanuel","family":"Nicolini","sequence":"additional","affiliation":[{"name":"CNRS UMR5286, INSERM U1052, Centre de Recherche en Canc\u00e9rologie de Lyon, F- 69008 Lyon, France"},{"name":"Centre L\u00e9on B\u00e9rard, F-69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Perot","sequence":"additional","affiliation":[{"name":"INSERM U1218, Institut Bergoni\u00e9, F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Robert","sequence":"additional","affiliation":[{"name":"UMR 8126, Universit\u00e9 Paris-Sud Paris-Saclay, CNRS, Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Fund","sequence":"additional","affiliation":[{"name":"\u00c9cole Normale Sup\u00e9rieure, PSL Research University, CNRS, Inserm, IBENS, Plateforme G\u00e9nomique, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chibon","sequence":"additional","affiliation":[{"name":"INSERM U1218, Institut Bergoni\u00e9, F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohong","family":"Xia","sequence":"additional","affiliation":[{"name":"Physics Department, East China Normal University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Wiels","sequence":"additional","affiliation":[{"name":"UMR 8126, Universit\u00e9 Paris-Sud Paris-Saclay, CNRS, Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Argoul","sequence":"additional","affiliation":[{"name":"LOMA, Universit\u00e9 de Bordeaux, CNRS, UMR 5798, F-33405 Talence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Maguer-Satta","sequence":"additional","affiliation":[{"name":"CNRS UMR5286, INSERM U1052, Centre de Recherche en Canc\u00e9rologie de Lyon, F- 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Arneodo","sequence":"additional","affiliation":[{"name":"LOMA, Universit\u00e9 de Bordeaux, CNRS, UMR 5798, F-33405 Talence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Audit","sequence":"additional","affiliation":[{"name":"Univ Lyon, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS, Laboratoire de Physique, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hyrien","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019\u00c9cole Normale Sup\u00e9rieure (IBENS), D\u00e9partement de Biologie, Ecole Normale Sup\u00e9rieure, CNRS, Inserm, PSL Research University, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"key\n\t\t\t\t2018110305210397300_B1","volume-title":"Genome Duplication","author":"DePamphilis","year":"2011"},{"key":"key\n\t\t\t\t2018110305210397300_B2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.201407004","article-title":"Peaks cloaked in the mist: the landscape of mammalian replication origins","volume":"208","author":"Hyrien","year":"2015","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B3","volume-title":"The Initiation of DNA Replication in Eukaryotes","author":"Hyrien","year":"2016"},{"key":"key\n\t\t\t\t2018110305210397300_B4","doi-asserted-by":"crossref","first-page":"R435","DOI":"10.1016\/j.cub.2014.04.012","article-title":"DNA replication and oncogene-induced replicative stress","volume":"24","author":"Hills","year":"2014","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B6","first-page":"1","article-title":"DNA replication stress: from molecular mechanisms to human disease","volume":"26","author":"Munoz","year":"2016","journal-title":"Chromosoma"},{"key":"key\n\t\t\t\t2018110305210397300_B7","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1038\/ncomms10660","article-title":"A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells","volume":"7","author":"Ahuja","year":"2016","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2018110305210397300_B8","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1038\/ncomms9548","article-title":"Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality","volume":"6","author":"Alvarez","year":"2015","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2018110305210397300_B9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature13619","article-title":"Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells","volume":"512","author":"Flach","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature03482","article-title":"DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis","volume":"434","author":"Bartkova","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature05268","article-title":"Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints","volume":"444","author":"Bartkova","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nature03485","article-title":"Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions","volume":"434","author":"Gorgoulis","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B13","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1140735","article-title":"An oncogene-induced DNA damage model for cancer development","volume":"319","author":"Halazonetis","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t2018110305210397300_B14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrc3916","article-title":"Replication stress and cancer","volume":"15","author":"Gaillard","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t2018110305210397300_B15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature05953","article-title":"Non-transcriptional control of DNA replication by c-Myc","volume":"448","author":"Dominguez-Sola","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.celrep.2013.04.002","article-title":"Cdc45 is a critical effector of myc-dependent DNA replication stress","volume":"3","author":"Srinivasan","year":"2013","journal-title":"Cell Rep."},{"key":"key\n\t\t\t\t2018110305210397300_B17","doi-asserted-by":"crossref","first-page":"13087","DOI":"10.1038\/ncomms13087","article-title":"Increased global transcription activity as a mechanism of replication stress in cancer","volume":"7","author":"Kotsantis","year":"2016","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2018110305210397300_B18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature25507","article-title":"Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress","volume":"555","author":"Macheret","year":"2018","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13986","article-title":"Topologically associating domains are stable units of replication-timing regulation","volume":"515","author":"Pope","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/epi.4.2.7772","article-title":"Replication timing as an epigenetic mark","volume":"4","author":"Hiratani","year":"2009","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2018110305210397300_B21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.semcancer.2013.01.001","article-title":"DNA replication timing, genome stability and cancer: late and\/or delayed DNA replication timing is associated with increased genomic instability","volume":"23","author":"Donley","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B22","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1101\/gr.138511.112","article-title":"Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia","volume":"22","author":"Ryba","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t2018110305210397300_B23","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1038\/ncomms10208","article-title":"Replication landscape of the human genome","volume":"7","author":"Petryk","year":"2016","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2018110305210397300_B24","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"key\n\t\t\t\t2018110305210397300_B25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-319-19983-2_7","volume-title":"Chromosomal Translocations and Genome Rearrangements in Cancer","author":"Casolari","year":"2015"},{"key":"key\n\t\t\t\t2018110305210397300_B26","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood.V97.8.2406","article-title":"A model of human p210(bcr\/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR\/ABL-containing retroviral vector","volume":"97","author":"Zhao","year":"2001","journal-title":"Blood"},{"key":"key\n\t\t\t\t2018110305210397300_B27","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1182\/blood-2013-05-501460","article-title":"Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression","volume":"122","author":"Laperrousaz","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t2018110305210397300_B28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1158\/2159-8290.CD-13-0235","article-title":"MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction","volume":"4","author":"Asmussen","year":"2014","journal-title":"Cancer Discov."},{"key":"key\n\t\t\t\t2018110305210397300_B29","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1182\/blood-2017-08-801019","article-title":"Immature CML cells implement a BMP autocrine loop to escape TKI treatment","volume":"130","author":"Grockowiak","year":"2017","journal-title":"Blood"},{"key":"key\n\t\t\t\t2018110305210397300_B30","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1101\/gr.098947.109","article-title":"Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes","volume":"20","author":"Chen","year":"2010","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t2018110305210397300_B31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1073\/pnas.0912402107","article-title":"Sequencing newly replicated DNA reveals widespread plasticity in human replication timing","volume":"107","author":"Hansen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2018110305210397300_B32","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1101\/gr.6081407","article-title":"Identification of higher-order functional domains in the human ENCODE regions","volume":"17","author":"Thurman","year":"2007","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t2018110305210397300_B33","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Green","year":"2012"},{"key":"key\n\t\t\t\t2018110305210397300_B34","doi-asserted-by":"crossref","first-page":"e1002443","DOI":"10.1371\/journal.pcbi.1002443","article-title":"Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines","volume":"8","author":"Baker","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nprot.2012.145","article-title":"Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm","volume":"8","author":"Audit","year":"2013","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t2018110305210397300_B36","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t2018110305210397300_B37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF00163235","article-title":"Statistical analysis of vertebrate sequences reveals that long genes are scarce in GC-rich isochores","volume":"40","author":"Duret","year":"1995","journal-title":"J. Mol. Evol."},{"key":"key\n\t\t\t\t2018110305210397300_B38","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110305210397300_B39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/hmg\/ddh016","article-title":"Replication timing of the human genome","volume":"13","author":"Woodfine","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2018110305210397300_B40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0378-1119(01)00644-8","article-title":"Misunderstandings about isochores. Part 1","volume":"276","author":"Bernardi","year":"2001","journal-title":"Gene"},{"key":"key\n\t\t\t\t2018110305210397300_B41","doi-asserted-by":"crossref","first-page":"1010428317713394","DOI":"10.1177\/1010428317713394","article-title":"Deregulated expression of Cdc6 as BCR\/ABL-dependent survival factor in chronic myeloid leukemia cells","volume":"39","author":"Zhang","year":"2017","journal-title":"Tumour Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B42","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.dnarep.2013.04.022","article-title":"ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia","volume":"12","author":"Takagi","year":"2013","journal-title":"DNA Repair (Amst.)"},{"key":"key\n\t\t\t\t2018110305210397300_B43","doi-asserted-by":"crossref","first-page":"e1002322","DOI":"10.1371\/journal.pcbi.1002322","article-title":"Evidence for sequential and Increasing activation of replication origins along replication timing gradients in the human genome","volume":"7","author":"Guilbaud","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B44","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1016\/j.jmb.2013.09.021","article-title":"From simple bacterial and archaeal replicons to replication N\/U-domains","volume":"425","author":"Hyrien","year":"2013","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t2018110305210397300_B45","doi-asserted-by":"crossref","first-page":"e1003969","DOI":"10.1371\/journal.pcbi.1003969","article-title":"Embryonic stem cell specific \u2018master\u2019 replication origins at the heart of the loss of pluripotency","volume":"11","author":"Julienne","year":"2015","journal-title":"PLoS Comput. Biol."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/46\/19\/10157\/26333860\/gky797.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T19:13:41Z","timestamp":1571771621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/46\/19\/10157\/5090772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":45,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2018,9,5]]},"published-print":{"date-parts":[[2018,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gky797","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11,2]]},"published":{"date-parts":[[2018,9,5]]}}}