{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:54:26Z","timestamp":1790520866038,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-15-CE11-0021-01"],"award-info":[{"award-number":["ANR-15-CE11-0021-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"La Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["DBF20160635745"],"award-info":[{"award-number":["DBF20160635745"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council advanced","award":["294312"],"award-info":[{"award-number":["294312"]}]},{"name":"National Institute of Health","award":["1R01GM108889-01"],"award-info":[{"award-number":["1R01GM108889-01"]}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-06313"],"award-info":[{"award-number":["2017-06313"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1800431"],"award-info":[{"award-number":["CHE-1800431"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.1093\/nar\/gkz053","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T18:30:44Z","timestamp":1549650644000},"page":"3223-3232","source":"Crossref","is-referenced-by-count":22,"title":["Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-2774","authenticated-orcid":false,"given":"Simone","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zef A","family":"K\u00f6nst","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA 92697-2025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamsee K","family":"Voora","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA 92697-2025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniya","family":"Kashinskaya","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"},{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Zanette","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of California, Irvine, CA 91010-92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Mobley","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of California, Irvine, CA 91010-92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-9136","authenticated-orcid":false,"given":"Gulnara","family":"Yusupova","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris D","family":"Vanderwal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA 92697-2025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA"},{"name":"Tri-Institutional PhD Training Program in Chemical Biology, Weill Cornell Medicine, Rockefeller University, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Yusupov","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"},{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"key\n\t\t\t\t2019040603501415200_B1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/2159-8290.CD-17-0550","article-title":"How ribosomes translate cancer","volume":"7","author":"Sulima","year":"2017","journal-title":"Cancer Discov."},{"key":"key\n\t\t\t\t2019040603501415200_B2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature13737","article-title":"Structural basis for the inhibition of the eukaryotic ribosome","volume":"513","author":"Garreau\u00a0de\u00a0Loubresse","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040603501415200_B3","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nchem.2800","article-title":"Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides","volume":"9","author":"K\u00f6nst","year":"2017","journal-title":"Nat. Chem."},{"key":"key\n\t\t\t\t2019040603501415200_B4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.chembiol.2017.04.006","article-title":"Inhibition of eukaryotic translation by the antitumor natural product agelastatin A","volume":"24","author":"McClary","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"key\n\t\t\t\t2019040603501415200_B5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.str.2018.01.009","article-title":"The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth","volume":"26","author":"Pellegrino","year":"2018","journal-title":"Structure"},{"key":"key\n\t\t\t\t2019040603501415200_B6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1158\/1078-0432.CCR-13-1283","article-title":"Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia","volume":"20","author":"Gandhi","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t2019040603501415200_B7","doi-asserted-by":"crossref","first-page":"27720","DOI":"10.1038\/srep27720","article-title":"Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome","volume":"6","author":"Prokhorova","year":"2016","journal-title":"Scientific Rep."},{"key":"key\n\t\t\t\t2019040603501415200_B8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1261\/rna.2346806","article-title":"Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis","volume":"12","author":"Robert","year":"2006","journal-title":"RNA"},{"key":"key\n\t\t\t\t2019040603501415200_B9","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/AAC.00860-10","article-title":"Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis","volume":"54","author":"Llano-Sotelo","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"key\n\t\t\t\t2019040603501415200_B10","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1039\/C4SC01626B","article-title":"Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4\u2032-deoxy-4\u2032-fluoro neomycin analogs","volume":"5","author":"Hanessian","year":"2014","journal-title":"Chem. Sci."},{"key":"key\n\t\t\t\t2019040603501415200_B11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/jacs.5b12308","article-title":"Site-Selective aliphatic C-H chlorination using N-Chloroamides enables a synthesis of chlorolissoclimide","volume":"138","author":"Quinn","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"key\n\t\t\t\t2019040603501415200_B12","first-page":"493","article-title":"Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)","volume":"7","author":"Malochet-Grivois","year":"1992","journal-title":"Anti-cancer Drug Des."},{"key":"key\n\t\t\t\t2019040603501415200_B13","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1212642","article-title":"The structure of the eukaryotic ribosome at 3.0 A resolution","volume":"334","author":"Ben-Shem","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040603501415200_B14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"key\n\t\t\t\t2019040603501415200_B15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1107\/S0907444912001308","article-title":"Towards automated crystallographic structure refinement with phenix.refine","volume":"68","author":"Afonine","year":"2012","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"key\n\t\t\t\t2019040603501415200_B16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"key\n\t\t\t\t2019040603501415200_B17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"key\n\t\t\t\t2019040603501415200_B18","doi-asserted-by":"crossref","first-page":"154104","DOI":"10.1063\/1.3382344","article-title":"A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu","volume":"132","author":"Grimme","year":"2010","journal-title":"J. Chem. Phys."},{"key":"key\n\t\t\t\t2019040603501415200_B19","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1103\/PhysRevA.38.3098","article-title":"Density-functional exchange-energy approximation with correct asymptotic behavior","volume":"38","author":"Becke","year":"1988","journal-title":"Phys. Rev. A, Gen. Phys."},{"key":"key\n\t\t\t\t2019040603501415200_B20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B, Condensed Matter"},{"key":"key\n\t\t\t\t2019040603501415200_B21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1063\/1.469408","article-title":"Efficient molecular numerical integration schemes","volume":"102","author":"Treutler","year":"1995","journal-title":"J. Chem. Phys."},{"key":"key\n\t\t\t\t2019040603501415200_B22","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1039\/b508541a","article-title":"Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: design and assessment of accuracy","volume":"7","author":"Weigend","year":"2005","journal-title":"Phys. Chem. Chem. Phys.: PCCP"},{"key":"key\n\t\t\t\t2019040603501415200_B23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/wcms.1162","article-title":"Turbomole","volume":"4","author":"Furche","year":"2014","journal-title":"WIREs Comput. Mol. Sci."},{"key":"key\n\t\t\t\t2019040603501415200_B24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molcel.2015.09.013","article-title":"Functional dynamics within the human ribosome regulate the rate of active protein synthesis","volume":"60","author":"Ferguson","year":"2015","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t2019040603501415200_B25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nmeth.3769","article-title":"Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale","volume":"13","author":"Juette","year":"2016","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t2019040603501415200_B26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/nar\/gkj491","article-title":"Accurate energies of hydrogen bonded nucleic acid base pairs and triplets in tRNA tertiary interactions","volume":"34","author":"Oliva","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t2019040603501415200_B27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nchembio.274","article-title":"Aminoglycoside activity observed on single pre-translocation ribosome complexes","volume":"6","author":"Feldman","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"key\n\t\t\t\t2019040603501415200_B28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nsmb.3177","article-title":"Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation","volume":"23","author":"Wasserman","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"key\n\t\t\t\t2019040603501415200_B29","doi-asserted-by":"crossref","first-page":"E8603","DOI":"10.1073\/pnas.1707539114","article-title":"Miscoding-induced stalling of substrate translocation on the bacterial ribosome","volume":"114","author":"Alejo","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019040603501415200_B30","doi-asserted-by":"crossref","first-page":"e34252","DOI":"10.7554\/eLife.34252","article-title":"Dynamics of ribosomes and release factors during translation termination in E. coli","volume":"7","author":"Adio","year":"2018","journal-title":"eLife"},{"key":"key\n\t\t\t\t2019040603501415200_B31","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.celrep.2018.11.040","article-title":"tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis","volume":"25","author":"Flis","year":"2018","journal-title":"Cell Rep."},{"key":"key\n\t\t\t\t2019040603501415200_B32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature24482","article-title":"Visualization of chemical modifications in the human 80S ribosome structure","volume":"551","author":"Natchiar","year":"2017","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040603501415200_B33","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1080\/15476286.2016.1259781","article-title":"Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function","volume":"14","author":"Sloan","year":"2017","journal-title":"RNA Biol."},{"key":"key\n\t\t\t\t2019040603501415200_B34","doi-asserted-by":"crossref","first-page":"eaao0665","DOI":"10.1126\/sciadv.aao0665","article-title":"Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression","volume":"4","author":"Parks","year":"2018","journal-title":"Sci. Adv."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/6\/3223\/28285075\/gkz053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T07:25:17Z","timestamp":1573889117000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/6\/3223\/5316741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,2,13]]},"published-print":{"date-parts":[[2019,4,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz053","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,8]]},"published":{"date-parts":[[2019,2,13]]}}}